Results 11 to 20 of about 225,391 (343)
Transcriptional Regulation by Nrf2
Antioxidants & Redox Signaling, 2017 Significance: Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that coordinates the basal and stress-inducible activation of a vast array of cytoprotective genes.
C. Tonelli, I. I. C. Chio, D. Tuveson
semanticscholar +4 more sources
NRF2, a Superstar of Ferroptosis
Antioxidants, 2023 Ferroptosis is an iron-dependent and lipid peroxidation-driven cell death cascade, occurring when there is an imbalance of redox homeostasis in the cell.
Ruihan Yan +5 more
semanticscholar +4 more sources
Antioxidants, 2021 The transcription factor NRF2 is central to redox homeostasis in animal cells and is a well-known driver of chemoresistance in many types of cancer. Recently, new roles have been ascribed to NRF2 which include regulation of antiviral interferon responses and inflammation.
Herengt, Angela +2 more
openaire +4 more sources
The NRF2-p97-NRF2 negative feedback loop
Redox Biology, 2023 p97 is a ubiquitin-targeted ATP-dependent segregase that regulates proteostasis, in addition to a variety of other cellular functions. Previously, we demonstrated that p97 negatively regulates NRF2 by extracting ubiquitylated NRF2 from the KEAP1-CUL3-RBX1 E3 ubiquitin ligase complex, facilitating proteasomal destruction.
Aryatara Shakya +10 more
openaire +3 more sources
Archives of Pharmaceutical Sciences Ain Shams University, 2021 Background: Accumulating evidence proves that cisplatin, a widely used anticancer, causes acute kidney injury (AKI). Sitagliptin (Sita), a dipeptidyl peptidase-4 (DPP4) inhibitor, is a hypoglycemic agent that can promote tissue angiogenesis and cell ...
Mohamed Bassiony +4 more
doaj +1 more source
HDAC inhibitors increase NRF2-signaling in tumour cells and blunt the efficacy of co-adminstered cytotoxic agents [PDF]
, 2014 The NRF2 signalling cascade provides a primary response against electrophilic chemicals and oxidative stress. The activation of NRF2-signaling is anticipated to have adverse clinical consequences; NRF2 is activated in a number of cancers and ...
Campbell, Kathryn H. +5 more
core +7 more sources
Autophagy and liver cancer [PDF]
Clinical and Molecular Hepatology, 2020 Autophagy is a highly conserved catabolic process that degrades cytosolic proteins and organelles via formation of autophagosomes that fuse with lysosomes to form autolysosomes, whereby autophagic cargos are degraded.
Xiaojuan Chao +4 more
doaj +1 more source
NRF2, a Transcription Factor for Stress Response and Beyond
International Journal of Molecular Sciences, 2020 Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the cellular defense against toxic and oxidative insults through the expression of genes involved in oxidative stress response and drug detoxification.
Feng He, Xiaoli Ru, T. Wen
semanticscholar +1 more source
Keap1/Nrf2 Signaling Pathway [PDF]
Antioxidants, 2021 Nuclear factor, erythroid 2-like transcription factor 2 (Nrf2) and its cytoplasmic inhibitor, kelch-like ECH-associated protein 1 (Keap1), comprise a redox-responsive endogenous antioxidant defense module that orchestrates the expression of cytoprotective genes to maintain homeostasis [...]
openaire +4 more sources
The KEAP1-NRF2 pathway: Targets for therapy and role in cancer
Redox Biology, 2023 The KEAP1-NRF2 pathway is the key regulator of cellular defense against both extrinsic and intrinsic oxidative and electrophilic stimuli. Since its discovery in the 1990s, its seminal role in various disease pathologies has become well appreciated ...
S. Adinolfi +7 more
semanticscholar +1 more source