Results 21 to 30 of about 200,244 (343)
Biomarker Exploration in Human Peripheral Blood Mononuclear Cells for Monitoring Sulforaphane Treatment Responses in Autism Spectrum Disorder [PDF]
, 2020 Autism Spectrum Disorder (ASD) is one of the most common neurodevelopmental disorders with no drugs treating the core symptoms and no validated biomarkers for clinical use.
Connors, Susan L. +7 more
core +3 more sources
Dangerous Entrapment for NRF2 [PDF]
Cell, 2016 Progerin, a mutated lamin A, causes the severe premature-aging syndrome Hutchinson-Gilford progeria (HGPS). Kubben et al. present a driving mechanism for HGPS involving trapping of NRF2 at the nuclear periphery by progerin. This local restriction results in impaired NRF2 signaling and chronic oxidative stress.
Vera, Gorbunova +2 more
openaire +2 more sources
Antioxidants, 2019 Acute kidney injury (AKI) is a serious complication of methotrexate (MTX). This study explored the protective effect of the isoflavone formononetin (FN) against MTX nephrotoxicity with an emphasis on oxidative stress, inflammation, and nuclear factor ...
Saleem H. Aladaileh +8 more
doaj +1 more source
Viral delivery of antioxidant genes as a therapeutic strategy in experimental models of amyotrophic lateral sclerosis. [PDF]
, 2013 Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder with no effective treatment to date. Despite its multi-factorial aetiology, oxidative stress is hypothesized to be one of the key pathogenic mechanisms.
Azzouz, M +6 more
core +1 more source
Nrf2 Modulation in Breast Cancer
Biomedicines, 2022 Reactive oxygen species (ROS) are identified to control the expression and activity of various essential signaling intermediates involved in cellular proliferation, apoptosis, and differentiation. Indeed, ROS represents a double-edged sword in supporting cell survival and death.
Somayyeh Ghareghomi +4 more
openaire +3 more sources
Effects of different-intensity exercise and creatine supplementation on mitochondrial biogenesis and redox status in mice [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): Dietary supplementation combined with exercise may potentiate the beneficial effects of exercise by reducing exercise-induced oxidative stress and improving mitochondrial quality and capacity.
Seyhan Taskin +4 more
doaj +1 more source
A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling. [PDF]
, 2018 Mechanisms that integrate the metabolic state of a cell with regulatory pathways are necessary to maintain cellular homeostasis. Endogenous, intrinsically reactive metabolites can form functional, covalent modifications on proteins without the aid of ...
A Cleasby +47 more
core +2 more sources
Suppressed ubiquitination of Nrf2 by p47phox contributes to Nrf2 activation [PDF]
Free Radical Biology and Medicine, 2017 Although critical in phagocytosis in innate immunity, reactive oxygen species (ROS) collaterally inflict damage to host phagocytes because they indiscriminate targets. Since Nrf2 increases the expression of anti-oxidant enzymes that nullifies ROS, ROS activating Nrf2 is a critical negative regulatory step for countering the deleterious effects of ROS ...
Kyun, Ha Kim +6 more
openaire +2 more sources
Andrographolide, a Natural Antioxidant: An Update
Antioxidants, 2019 Traditionally, Andrographis paniculata has been used as an herbal remedy for lung infection treatments. Its leaves contain a diterpenoid labdane called andrographolide responsible for a wide range of biological activities such as antioxidant, anti ...
Eugenie Mussard +5 more
doaj +1 more source
The Role of Reactive Oxygen Species in Arsenic Toxicity
Biomolecules, 2020 Arsenic poisoning is a global health problem. Chronic exposure to arsenic has been associated with the development of a wide range of diseases and health problems in humans. Arsenic exposure induces the generation of intracellular reactive oxygen species
Yuxin Hu +8 more
doaj +1 more source