Results 51 to 60 of about 225,391 (343)

Opposing effects of Nrf2 and Nrf2‐activating compounds on the NLRP3 inflammasome independent of Nrf2‐mediated gene expression [PDF]

European Journal of Immunology, 2017
The transcription factor Nrf2 regulates the expression of genes required for protection from xenobiotic and oxidative stress. Under normal conditions Nrf2 is constantly degraded upon ubiquitination, mediated by the Nrf2 inhibitor Keap1. Inflammasomes represent stress‐induced protein complexes.
Garstkiewicz, Martha, Strittmatter, Gerhard E, Grossi, Serena, Sand, Jennifer, Fenini, Gabriele, Werner, Sabine, French, Lars E, Beer, Hans-Dietmar   +7 more
openaire   +3 more sources

The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

Molecular and Cellular Biology, 2020
The KEAP1-NRF2 pathway is the principal protective response to oxidative and electrophilic stresses. Under homeostatic conditions, KEAP1 forms part of an E3 ubiquitin ligase, which tightly regulates the activity of the transcription factor NRF2 by ...
Liam Baird, Masayuki Yamamoto
semanticscholar   +1 more source

A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling. [PDF]

, 2018
Mechanisms that integrate the metabolic state of a cell with regulatory pathways are necessary to maintain cellular homeostasis. Endogenous, intrinsically reactive metabolites can form functional, covalent modifications on proteins without the aid of ...
A Cleasby, A Dhar, A Kobayashi, A Moraru, A Shevchenko, A Uruno, AC Ruifrok, Arnab K. Chatterjee, BR Sabari, BT Weinert, CL Saw, Claudio Zambaldo, D Martinez Molina, DD Zhang, Emily N. Chin, FW Chaplen, Gihoon Lee, GP Sykiotis, GR Wagner, H Lin, Hwayoung Yun, Insha Ahmad, Jae Won Chang, John S. Coukos, JW Chang, Luke L. Lairson, M Ravichandran, MC Jaramillo, Michael J. Bollong, N Rabbani, N Rabbani, N Wakabayashi, Peter G. Schultz, Raymond E. Moellering, RE Moellering, RH Scannevin, S Nishimoto, S Tao, SC Lo, T Bücher, T Ogura, TB El-Abaseri, TO Khor, TW Lo, W Hur, W Hur, Y Mitsuishi, Z Zhang   +47 more
core   +2 more sources

Apigenin Alleviates Allodynia and Hyperalgesia in a Mouse Model of Chemotherapy-Induced Peripheral Neuropathy via Regulating Microglia Activation and Polarization

Journal of Integrative Neuroscience, 2023
Background: Apigenin has been reported to exhibit anti-inflammatory and anti-oxidative activities. This study aimed to investigate the protective role of Apigenin on chemotherapy-induced peripheral neuropathy (CIPN).
Wenji Xie, Wenqin Xie, Changcheng Jiang, Zhenming Kang, Naizhen Liu   +4 more
doaj   +1 more source

An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation

Molecules, 2020
Inflammation is a key driver in many pathological conditions such as allergy, cancer, Alzheimer’s disease, and many others, and the current state of available drugs prompted researchers to explore new therapeutic targets.
S. Saha, B. Buttari, E. Panieri, E. Profumo, L. Saso   +4 more
semanticscholar   +1 more source

Advances and challenges in therapeutic targeting of NRF2.

TIPS - Trends in Pharmacological Sciences, 2023
Activation of the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is emerging as an attractive therapeutic approach to counteract oxidative stress, inflammation, and metabolic imbalances.
A. Dinkova-Kostova, I. Copple
semanticscholar   +1 more source

The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress*

Journal of Biological Chemistry, 2009
A major mechanism in the cellular defense against oxidative or electrophilic stress is activation of the Nrf2-antioxidant response element signaling pathway, which controls the expression of genes whose protein products are involved in the detoxication ...
Truyen Nguyen, P. Nioi, C. B. Pickett
semanticscholar   +1 more source

Nrf1 acts as a highly-conserved determinon for maintaining robust redox homeostasis in the eco-evo-devo process of life histories

Cell Stress
Differential and even opposing functions of two major antioxidant transcription factors Nrf1 and Nrf2 (encoded by Nfe2l1 and Nfe2l2, respectively) are determined by distinctions in their tempospatial positioning, topological repartitioning, proteolytic ...
Yiguo Zhang, Xi Chen, Meng Wang, Yuping Zhu, Wei Shi, Chao Li, Zhengwen Zhang, Hiroaki Taniguchi, Ping Ao   +8 more
doaj   +1 more source

Isoliquiritigenin attenuates neuroinflammation in mice model of Parkinson’s disease by promoting Nrf2/NQO-1 pathway

Translational Neuroscience, 2022
Parkinson’s disease (PD) is a common neurodegenerative disease that severely affects the quality of life of patients. There is no specific drug for PD up to now.
Huang Lijuan, Han Yan, Zhou Qingmin, Sun Zhihao, Yan Jianhui   +4 more
doaj   +1 more source

NRF2-driven miR-125B1 and miR-29B1 transcriptional regulation controls a novel anti-apoptotic miRNA regulatory network for AML survival [PDF]

, 2014
Transcription factor NRF2 is an important regulator of oxidative stress. It is involved in cancer progression, and has abnormal constitutive expression in acute myeloid leukaemia (AML).
A Ooi, AG Ooi, BN Chorley, BT Kvinlaug, C Luna, CR Zhao, D J MacEwan, E Estey, E Surdziel, F Kong, G Tan, GM DeNicola, H Wang, H Zhang, I Spinello, J Alam, J Gong, J Winter, JE Anderson, JJ Tsai, JJ Zhao, JN Gong, K M Bowles, K Okamoto, L Zaitseva, L Zaitseva, M Bousquet, M Bousquet, MB Sporn, MY Murray, N Hanada, N M Shah, P Moi, PA Konstantinopoulos, R Garzon, R Garzon, R Garzon, R Venugopal, S A Rushworth, S Liu, SA Rushworth, SA Rushworth, SA Rushworth, TWP Devling, W Blum, Y Wang, YR Kim   +46 more
core   +1 more source