Results 61 to 70 of about 225,391 (343)

Nrf2 activation through the inhibition of Keap1–Nrf2 protein–protein interaction

Medicinal Chemistry Research, 2020
Activation of the transcription factor Nrf2 via the Keap1-Nrf2-ARE signaling system regulates the transcription and subsequent expression of cellular cytoprotective proteins and plays a crucial role in preventing pathological conditions exacerbated by the overproduction of oxidative stress.
Sumi Lee, Longqin Hu
openaire   +3 more sources

Nrf2 Inhibits the Progression of Parkinson’s Disease by Upregulating AABR07032261.5 to Repress Pyroptosis

Journal of Inflammation Research, 2022
Yunxiao Zhong,1,* Xiaodong Cai,2,* Li Ding,3,* Jinchi Liao,1 Xu Liu,1 Yiying Huang,1 Xiaohong Chen,1 Ling Long1 1Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong Province, 510600, People’s
Zhong Y, Cai X, Ding L, Liao J, Liu X, Huang Y, Chen X, Long L   +7 more
doaj  

Epicatechin induces NF-kappa B, activator rotein-1 (AP-1) and nuclear transcription factor erythroid 2p45-related factor-2 (Nrf2) via phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) and extracellular regulated kinase (ERK) signalling in HepG2 cells [PDF]

, 2009
The dietary flavonoid epicatechin has been reported to exhibit a wide range of biological activities. The objective of the present study was to investigate the time-dependent regulation by epicatechin on the activity of the main transcription factors (NF-
Bravo, Laura, Goya, Luis, Granado-Serrano, Ana Belen, Haegeman, Guy, Martin, Maria Anegeles, Ramos, Sonia   +5 more
core   +4 more sources

Chinese Herbs and Repurposing Old Drugs as Therapeutic Agents in the Regulation of Oxidative Stress and Inflammation in Pulmonary Diseases

Journal of Inflammation Research, 2021
Chien-Chung Yang,1,2 Chuen-Mao Yang3– 5 1Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital at Tao-Yuan, Kwei-San, Tao-Yuan, 33302, Taiwan; 2School of Traditional Chinese Medicine, College of Medicine, Chang Gung University ...
Yang CC, Yang CM
doaj  

Nrf2and Cardiovascular Defense [PDF]

Oxidative Medicine and Cellular Longevity, 2013
The cardiovascular system is susceptible to a group of diseases that are responsible for a larger proportion of morbidity and mortality than any other disease. Many cardiovascular diseases are associated with a failure of defenses against oxidative stress-induced cellular damage and/or death, leading to organ dysfunction.
openaire   +2 more sources

NRF2 regulation in the developing brain cortex from rat offspring exposed to intrauterine and early postnatal zinc deficits

Redox Experimental Medicine
Objective: Transcription factor NRF2, master regulator of the antioxidant response, is also involved in brain development. This paper investigated the role of NRF2 in developmental zinc deficiency-associated alterations in rat brain cortex: i ...
Wei Zhu, Patricia I Oteiza
doaj   +1 more source

Nrf2/Keap1/ARE signaling: Towards specific regulation

Life Science, 2021
The Nrf2 transcription factor governs the expression of hundreds genes involved in cell defense against oxidative stress, the hallmark of numerous diseases such as neurodegenerative, cardiovascular, some viral pathologies, diabetes and others.
A. V. Ulasov, A. A. Rosenkranz, G. Georgiev, A. S. Sobolev   +3 more
semanticscholar   +1 more source

Dimethyl Fumarate Alleviates Dextran Sulfate Sodium-Induced Colitis, through the Activation of Nrf2-Mediated Antioxidant and Anti-inflammatory Pathways. [PDF]

, 2020
Oxidative stress and chronic inflammation play critical roles in the pathogenesis of ulcerative colitis (UC) and inflammatory bowel diseases (IBD). A previous study has demonstrated that dimethyl fumarate (DMF) protects mice from dextran sulfate sodium ...
Farzaneh, Ted, Ichii, Hirohito, Lau, Hien, Li, Shiri, Robles, Lourdes, Stamos, Michael J, Takasu, Chie, Vaziri, Nosratola D, Vo, Kelly   +8 more
core   +2 more sources

Roles of Oxidative Stress and Nrf2 Signaling in Pathogenic and Non-Pathogenic Cells: A Possible General Mechanism of Resistance to Therapy

Antioxidants, 2023
The coordinating role of nuclear factor erythroid-2-related factor 2 (Nrf2) in cellular function is undeniable. Evidence indicates that this transcription factor exerts massive regulatory functions in multiple signaling pathways concerning redox ...
Mira Hammad, M. Raftari, Rute Cesário, Rima Salma, Paulo R D V Godoy, S. Emami, S. Haghdoost   +6 more
semanticscholar   +1 more source

Stress Resistance Screen in a Human Primary Cell Line Identifies Small Molecules That Affect Aging Pathways and Extend Caenorhabditis elegans' Lifespan. [PDF]

, 2020
Increased resistance to environmental stress at the cellular level is correlated with the longevity of long-lived mutants and wild-animal species. Moreover, in experimental organisms, screens for increased stress resistance have yielded mutants that are ...
Ang, Kenny Kean-Hooi, Arkin, Michelle, Cregg, James, Kenyon, Cynthia, Zhai, Yuying, Zhang, Peichuan   +5 more
core   +2 more sources