Results 71 to 80 of about 200,244 (343)

Cellular Modulators of the NRF2/KEAP1 Signaling Pathway in Prostate Cancer

Frontiers in Bioscience-Landmark, 2023
Prostate cancer is the second most common malignancy in men worldwide. Prostate cancer can be treated by surgery, radiotherapy and hormone therapy. The latter, in the form of androgen-deprivation therapy is needed to reduce prostate cancer progression at
Giovanni Tossetta, Sonia Fantone, Daniela Marzioni, Roberta Mazzucchelli   +3 more
doaj   +1 more source

Fluorescent Nanodiamonds Based Theranostic Platform for pH‐Sensitive Drug Delivery and Quantum Sensing

Advanced Functional Materials, EarlyView.
A multifunctional nanodiamond platform enables pH‐triggered Diazoxide (DZX) delivery and quantum sensing of subcellular radical dynamics in triple‐negative breast cancer cells. Diamond relaxometry revealed reduced lysosomal radicals during DZX‐induced mitochondrial radical elevation, providing insights into redox modulation and organelle‐ resolved ...
Kaiqui Wu, Siyu Fan, Yue Zhang, Willem Woudstra, Thomas Mulder, Laurens Boscher Navarro, Jur van Dijken, Katja Loos, Romana Schirhagl   +8 more
wiley   +1 more source

miR-380-5p facilitates NRF2 and attenuates cerebral ischemia/reperfusion injury-induced neuronal cell death by directly targeting BACH1

Translational Neuroscience, 2021
This study aimed to explore the role of miR-380-5p in cerebral ischemia/reperfusion (CIR) injury-induced neuronal cell death and the potential signaling pathway involved.
Wang Yibiao, Xu Min
doaj   +1 more source

Epicatechin induces NF-kappa B, activator rotein-1 (AP-1) and nuclear transcription factor erythroid 2p45-related factor-2 (Nrf2) via phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) and extracellular regulated kinase (ERK) signalling in HepG2 cells [PDF]

, 2009
The dietary flavonoid epicatechin has been reported to exhibit a wide range of biological activities. The objective of the present study was to investigate the time-dependent regulation by epicatechin on the activity of the main transcription factors (NF-
Bravo, Laura, Goya, Luis, Granado-Serrano, Ana Belen, Haegeman, Guy, Martin, Maria Anegeles, Ramos, Sonia   +5 more
core   +4 more sources

NRF2: Translating the Redox Code [PDF]

Trends in Molecular Medicine, 2016
Cancer requires mechanisms to mitigate reactive oxygen species (ROS) generated during rapid growth, such as induction of the antioxidant transcription factor, Nrf2. However, the targets of ROS-mediated cytotoxicity are unclear. Recent studies in pancreatic cancer show that redox control by Nrf2 prevents cysteine oxidation of the mRNA translational ...
Krishna S, Tummala, Filippos, Kottakis, Nabeel, Bardeesy   +2 more
openaire   +2 more sources

A Smart Bio‐Battery Facilitates Diabetic Bone Defect Repair Via Inducing Macrophage Reprogramming and Synergistically Modulating Bone Remodeling Coupling

Advanced Functional Materials, EarlyView.
This research presents a novel implantable bio‐battery, GF‐OsG, tailored for diabetic bone repair. GF‐OsG generates microcurrents in high‐glucose conditions to enhance vascularization, shift macrophages to the M2 phenotype, and regulate immune responses.
Nanning Lv, Haifu Sun, Wenxiang Tang, Yonggang Li, Zhonglai Qian, Lihui Hong, Chong Chen, Hongye Li, Jiaxiang Bai, Yusen Qiao, Mingming Liu   +10 more
wiley   +1 more source

Protective Effect of Astaxanthin on Ochratoxin A-Induced Kidney Injury to Mice by Regulating Oxidative Stress-Related NRF2/KEAP1 Pathway

Molecules, 2020
The present study aimed to investigate the effects of astaxanthin (ASX) on ochratoxin A (OTA)-induced renal oxidative stress and its mechanism of action.
Lin Li, Yueli Chen, Danyang Jiao, Shuhua Yang, Lin Li, Peng Li   +5 more
doaj   +1 more source

Marburgvirus Hijacks Nrf2-Dependent Pathway by Targeting Nrf2-Negative Regulator Keap1

Cell Reports, 2014
Marburg virus (MARV) has a high fatality rate in humans, causing hemorrhagic fever characterized by massive viral replication and dysregulated inflammation. Here, we demonstrate that VP24 of MARV binds Kelch-like ECH-associated protein 1 (Keap1), a negative regulator of nuclear transcription factor erythroid-derived 2 (Nrf2).
Page, Audrey, Volchkova, Valentina A, Reid, Saint Patrick, Mateo, Mathieu, Bagnaud-Baule, Audrey, Nemirov, Kirill, Shurtleff, Amy C, Lawrence, Philip, Reynard, Olivier, Ottmann, Michele, Lotteau, Vincent, Biswal, Shyam S, Thimmulappa, Rajesh K, Bavari, Sina, Volchkov, Viktor E   +14 more
openaire   +4 more sources

Modular Platform for Rapidly Investigating Long‐Distance Propagation of Human Neural Network Activity

Advanced Healthcare Materials, EarlyView.
This study presents the first human neural organoid culture model capable of rapidly exhibiting long‐distance neural network propagation, thus delivering a system to experimentally investigate large‐scale communication during normal and diseased states.
Megh Dipak Patel, Sailee Sham Lavekar, Ronak Jaisalmeria, Suki Oji, Jazmine Jayasi, Caroline Cvetkovic, Robert Krencik   +6 more
wiley   +1 more source

Sappanone A Protects Against Myocardial Ischemia Reperfusion Injury by Modulation of Nrf2

Drug Design, Development and Therapy, 2020
Xiaojing Shi, Guizhou Tao, Lili Ji, Ge Tian Department of Cardiology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, People’s Republic of ChinaCorrespondence: Xiaojing ShiDepartment of Cardiology, The First Affiliated ...
Shi X, Tao G, Ji L, Tian G
doaj