Results 31 to 40 of about 80,339 (259)
BMC Cancer, 2019 Background Nuclear factor erythroid 2–related factor 2 (Nrf2) is involved in cell proliferation by promotion of metabolic activity. It is also the major regulator of antioxidants and has a pivotal role in tumor cell proliferation and resistance to ...
Yoshiyuki Yamaguchi +6 more
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Expression of NRF2 and NRF2-modulated genes in peripheral blood leukocytes of bladder cancer males
Neoplasma, 2012 Nuclear factor (erythroid-derived 2)-like 2 (NRF2) is an oxidant-responsive transcription factor involved in induction of antioxidant genes. We assessed NRF2 and selected NRF2-modulated gene expression: glutathione S-transferase A1 and P1 (GSTA1 and GSTP1), mitochondrial superoxide dismutase (SOD2) in blood leukocytes of 51 bladder cancer patients and ...
E, Reszka +6 more
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BMC Cancer, 2022 Background Pheochromocytomas (PCC) and paragangliomas (PGL) are catecholamine-producing neuroendocrine tumors. According to the World Health Organization Classification 2017, all PCC/PGL are considered to have malignant potential.
Takao Kamai +6 more
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AMPK Enhances Transcription of Selected Nrf2 Target Genes via Negative Regulation of Bach1
Frontiers in Cell and Developmental Biology, 2020 5′-AMP-activated protein kinase (AMPK) and the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) are main players in the cellular adaptive response to metabolic and oxidative/xenobiotic stress, respectively.
Katrin Fischhuber +2 more
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eLife, 2018 Diurnal oscillation of intracellular redox potential is known to couple metabolism with the circadian clock, yet the responsible mechanisms are not well understood.
Ryan S Wible +6 more
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Current Research in Toxicology, 2023 The detoxification of quinones through NAD(P)H:quinone oxidoreductase (NQO1) is a crucial mechanism to maintain cellular homeostasis. The exposure to heavy metals, specifically methylmercury (MeHg), induces several antioxidant enzymes, including NQO1 ...
Mohammed A. Alqahtani +3 more
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SPBP is a sulforaphane induced transcriptional coactivator of NRF2 regulating expression of the autophagy receptor p62/SQSTM1. [PDF]
PLoS ONE, 2014 Organisms exposed to oxidative stress respond by orchestrating a stress response to prevent further damage. Intracellular levels of antioxidant agents increase, and damaged components are removed by autophagy induction.
Sagar Ramesh Darvekar +4 more
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Nrf2 pathway regulates multidrug-resistance-associated protein 1 in small cell lung cancer.
PLoS ONE, 2013 Although multidrug-resistance-associated protein-1 (MRP1) is a major contributor to multi-drug resistance (MDR), the regulatory mechanism of Mrp1 still remains unclear.
Lili Ji +6 more
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Regulation of γ-Glutamylcysteine Synthetase Subunit Gene Expression by the Transcription Factor Nrf2 [PDF]
Journal of Biological Chemistry, 1999 Exposure of HepG2 cells to beta-naphthoflavone (beta-NF) or pyrrolidine dithiocarbamate (PDTC) resulted in the up-regulation of the gamma-glutamylcysteine synthetase catalytic (GCS(h)) and regulatory (GCS(l)) subunit genes. Increased expression was associated with an increase in the binding of Nrf2 to electrophile response elements (EpRE) in the ...
A C, Wild, H R, Moinova, R T, Mulcahy
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The Mediator Subunit MED16 Transduces NRF2-Activating Signals into Antioxidant Gene Expression [PDF]
Molecular and Cellular Biology, 2016 The KEAP1-NRF2 system plays a central role in cytoprotection. NRF2 is stabilized in response to electrophiles and activates transcription of antioxidant genes. Although robust induction of NRF2 target genes confers resistance to oxidative insults, how NRF2 triggers transcriptional activation after binding to DNA has not been elucidated. To decipher the
Hiroki, Sekine +9 more
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