Results 31 to 40 of about 115,081 (308)

Viral delivery of antioxidant genes as a therapeutic strategy in experimental models of amyotrophic lateral sclerosis. [PDF]

, 2013
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder with no effective treatment to date. Despite its multi-factorial aetiology, oxidative stress is hypothesized to be one of the key pathogenic mechanisms.
Azzouz, M, Higginbottom, A, Nanou, A, Ning, K, Shaw, P, Valori, CF, Wyles, M   +6 more
core   +1 more source

MiR-144 Regulates Hemoglobin Expression in Human Erythroid Cell Line

Walailak Journal of Science and Technology, 2020
The regulation of globin gene expression is significantly important to understand the pathogenesis of globin gene disorders. Recent findings have shown that microRNAs (miRNAs, miRs) play an important role in the regulation of globin gene expression. The
Tipparat PENGLONG, Apisara SAENSUWANNA, Jitpanu KOCHAROENWAT, Wittawat BOORINTARAGOT, Suppanut FUPONGSIRIPHAN, Kanitta SRINOUN   +5 more
doaj   +3 more sources

HDAC inhibitors increase NRF2-signaling in tumour cells and blunt the efficacy of co-adminstered cytotoxic agents [PDF]

, 2014
The NRF2 signalling cascade provides a primary response against electrophilic chemicals and oxidative stress. The activation of NRF2-signaling is anticipated to have adverse clinical consequences; NRF2 is activated in a number of cancers and ...
Campbell, Kathryn H., Henderson, Colin J., MacLeod, A. Kenneth, McLaughlin, Lesley A., McMahon, Michael, Wolf, C. Roland   +5 more
core   +13 more sources

Possible involvement of nuclear factor erythroid 2-related factor 2 in the gene expression of Cyp2b10 and Cyp2a5

Redox Biology, 2014
Cytochrome P450 gene expression is altered by various chemical compounds. In this study, we used nuclear factor erythroid 2-related factor 2 (Nrf2)–deficient (Nrf2−⧸−) mice to investigate the involvement of Nrf2 in Cyp2b10 and Cyp2a5 gene expression ...
Takashi Ashino, Haruyo Ohkubo-Morita, Masayuki Yamamoto, Takemi Yoshida, Satoshi Numazawa   +4 more
doaj   +1 more source

Cloning and expression analysis of the nuclear factor erythroid 2-related factor 2 (Nrf2) gene of grass carp (Ctenopharyngodon idellus) and the dietary effect of Eucommia ulmoides on gene expression

Aquaculture and Fisheries, 2018
Nuclear factor erythroid 2-related factor 2 (Nrf2) is an important transcription factor in the regulation of redox homeostasis, which plays a vital role in metabolism, the cell cycle, and cell protection. In this study, the complete cDNA sequence of Nrf2
Junpeng Wang, Jun Xie, Zhihan Tu, Jing Wei, Wenqian Pan, Jing Hu, Yi Zhang, Xiangjun Leng, Xiaoqin Li   +8 more
doaj   +1 more source

NFE2-Related transcription factor 2 coordinates antioxidant defense with thyroglobulin production and iodination in the thyroid gland [PDF]

, 2018
Background: The thyroid gland has a special relationship with oxidative stress. While generation of oxidative substances is part of normal iodide metabolism during thyroid hormone synthesis, the gland must also defend itself against excessive oxidation ...
Amendola, Elena, Bongiovanni, Massimo, Carrasco, Nancy, Chartoumpekis, Dionysios V, Habeos, Ioannis, Juvenal, Guillermo Juan, Kensler, Thomas W., Liao, Xiao-Hui, Ntalampyra, Eleni, Refetoff, Samuel, Renaud, Cédric O., Ris Stalpers, Carrie, Rossich, Luciano Esteban, Santisteban, Pilar, Somm, Emmanuel, Sykiotis, Gerasimos P., Thomasz, Lisa, Trougakos, Ioannis P, Yamamoto, Masayuki, Ziros, Panos G   +19 more
core   +1 more source

Mining a human transcriptome database for chemical modulators of NRF2.

PLoS ONE, 2020
Nuclear factor erythroid-2 related factor 2 (NRF2) encoded by the NFE2L2 gene is a transcription factor critical for protecting cells from chemically-induced oxidative stress.
John P Rooney, Brian Chorley, Steven Hiemstra, Steven Wink, Xuting Wang, Douglas A Bell, Bob van de Water, J Christopher Corton   +7 more
doaj   +1 more source

Regulation of Nrf2 by Mitochondrial Reactive Oxygen Species in Physiology and Pathology

Biomolecules, 2020
Reactive oxygen species (ROS) are byproducts of aerobic respiration and signaling molecules that control various cellular functions. Nrf2 governs the gene expression of endogenous antioxidant synthesis and ROS-eliminating enzymes in response to various ...
Shuya Kasai, Sunao Shimizu, Yota Tatara, Junsei Mimura, Ken Itoh   +4 more
doaj   +1 more source

Role of G{alpha}12 and G{alpha}13 as Novel Switches for the Activity of Nrf2, a Key Antioxidative Transcription Factor [PDF]

, 2007
G{alpha}12 and G{alpha}13 function as molecular regulators responding to extracellular stimuli. NF-E2-related factor 2 (Nrf2) is involved in a protective adaptive response to oxidative stress.
Cho, Min Kyung, Choi, Sangdun, Hwang, Jong-Ik, Ki, Sung Hwan, Kim, Sang Geon, Kim, Won Dong, Lee, Chang Ho   +6 more
core   +2 more sources

Nrf2 and Keap1 Abnormalities in 104 Lung Adenocarcinoma Cases and Association with Clinicopathologic Features

Chinese Journal of Lung Cancer, 2018
Background and objective There are significantly interindividual variations of the expression level of nuclear factor erythroid-2-related factor 2 (Nrf2) and/or Kelch-like ECH-associated protein 1 (Keap1) in our previous studies.
Yu XIAO, Xiang ZHU, Yangchun GU, Sen CHEN, Li LIANG, Baoshan CAO   +5 more
doaj   +1 more source