Results 11 to 20 of about 80,339 (259)
Non-canonical Keap1-independent activation of Nrf2 in astrocytes by mild oxidative stress
Redox Biology, 2021 The transcription factor Nrf2 is a stress-responsive master regulator of antioxidant, detoxification and proteostasis genes. In astrocytes, Nrf2-dependent gene expression drives cell-autonomous cytoprotection and also non-cell-autonomous protection of ...
Bashayer R. Al-Mubarak +10 more
doaj +1 more source
Antioxidants, 2023 Nrf2 is a transcription factor facilitating cells’ resilience against redox and various other forms of stress. In the absence of stressors, KEAP1 and/or βTrCP mediate the ubiquitination of Nrf2 and prevent Nrf2-dependent gene expression and ...
Eleni Petsouki +3 more
doaj +1 more source
Opposing effects of Nrf2 and Nrf2‐activating compounds on the NLRP3 inflammasome independent of Nrf2‐mediated gene expression [PDF]
European Journal of Immunology, 2017 The transcription factor Nrf2 regulates the expression of genes required for protection from xenobiotic and oxidative stress. Under normal conditions Nrf2 is constantly degraded upon ubiquitination, mediated by the Nrf2 inhibitor Keap1. Inflammasomes represent stress‐induced protein complexes.
Garstkiewicz, Martha +7 more
openaire +4 more sources
Notch-Nrf2 Axis: Regulation of Nrf2 Gene Expression and Cytoprotection by Notch Signaling [PDF]
Molecular and Cellular Biology, 2014 The Notch signaling pathway enables regulation and control of development, differentiation, and homeostasis through cell-cell communication. Our investigation shows that Notch signaling directly activates the Nrf2 stress adaptive response pathway through recruitment of the Notch intracellular domain (NICD) transcriptosome to a conserved Rbpjκ site in ...
Nobunao, Wakabayashi +13 more
openaire +2 more sources
Functional Role of NRF2 in Cervical Carcinogenesis. [PDF]
PLoS ONE, 2015 Nuclear factor erythroid-2-related factor 2 (NFE2L2) is a transcription factor associated with resistance to chemotherapy and increased tumor growth. NRF2 is repressed by the inhibitor Keap1.
Jun-Qi Ma +5 more
doaj +1 more source
Antioxidants, 2021 The aberrant regulation of inflammatory gene transcription following oxidant and inflammatory stimuli can culminate in unchecked systemic inflammation leading to organ dysfunction.
Haranatha R. Potteti +7 more
doaj +1 more source
NRF2-dependent gene expression promotes ciliogenesis and Hedgehog signaling [PDF]
Scientific Reports, 2019 AbstractThe transcription factor NRF2 is a master regulator of cellular antioxidant and detoxification responses, but it also regulates other processes such as autophagy and pluripotency. In human embryonic stem cells (hESCs), NRF2 antagonizes neuroectoderm differentiation, which only occurs after NRF2 is repressed via a Primary Cilia-Autophagy-NRF2 ...
Ana Martin-Hurtado +7 more
openaire +5 more sources
The International Journal of Biological Markers, 2023 Background Many types of cancer exhibit high nuclear factor erythroid 2-related factor 2 (NRF2), which is effective in resisting drugs and radiation.
Yongmei Gao +4 more
doaj +1 more source
Differential expression of the Nrf2-linked genes in pediatric septic shock [PDF]
Critical Care, 2015 Abstract Introduction Experimental data from animal models of sepsis support a role for a transcription factor, nuclear erythroid-related factor 2 p45-related factor 2 (Nrf2), as a master regulator of antioxidant and detoxifying genes and intermediary metabolism during stress.
Grunwell, Jocelyn R. +15 more
openaire +2 more sources
Nrf2-DEPENDENT GENE EXPRESSIONS: A MOLECULAR TOXICOLOGICAL ASPECT
The Journal of Toxicological Sciences, 2004 Although NF-E2 related factor 2 (Nrf2) was found to be a transcriptional regulator that controls an expression of the beta-globin gene, the notion is now widely accepted that this transfactor serves as a master regulator for the gene expression of a battery of proteins acting on anti-oxidative stress and detoxification of electrophiles. The function of
NUMAZAWA, Satoshi, YOSHIDA, Takemi
openaire +3 more sources