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Renal expression of Bach1 and oxidative stress in chronic kidney disease: evidence from a preclinical model [PDF]
Brazilian Journal of NephrologyIntroduction: The transcription factor BTB and CNC homology 1 (Bach1) represses the nuclear factor erythroid 2–related factor 2 (Nrf2), which controls antioxidant gene expression, and its role in chronic kidney disease (CKD) remains unclear.
Beatriz Oliveira Da Cruz +5 more
doaj +5 more sources
Gene expression profiling following
Respiratory Research, 2012 Background Oxidative Stress contributes to the pathogenesis of many diseases. The NRF2/KEAP1 axis is a key transcriptional regulator of the anti-oxidant response in cells.
Fourtounis Jimmy +9 more
doaj +4 more sources
NRF2 function in osteocytes is required for bone homeostasis and drives osteocytic gene expression
Redox Biology, 2021 Osteocytes, the most abundant bone cell type, are derived from osteoblasts through a process in which they are embedded in an osteoid. We previously showed that nutrient restriction promotes the osteocyte transcriptional program and is associated with increased mitochondrial biogenesis.
Leonardo Pedrazza +2 more
exaly +5 more sources
BMC Medical GenomicsBackground and aims Preeclampsia (PE) is a serious medical condition that usually causes high blood pressure and affects multiple organs. Considering the adverse effect of oxidative stress on the process of PE in pregnant women and regarding the role of ...
Saba Zakeri +6 more
doaj +3 more sources
Evolution of Nrf2 Gene Expression in HIT-T15 β-Cells During Chronic Oxidative Stress and Glucose Toxicity. [PDF]
J Endocr Soc, 2023 Abebe T +3 more
europepmc +2 more sources
Gene Expression of Nrf2 and KEAP1 in Monocytes of Patients with Chronic Kidney Disease (CKD)
International Journal of Molecular SciencesIn chronic kidney disease (CKD), oxidative stress and inflammation contribute to disease progression and CKD-related morbidity. The nuclear factor erythroid 2-related factor 2 (Nrf2) system plays a central role in the cellular response to oxidative and inflammatory stress.
Subagini Nagarajah +2 more
exaly +3 more sources
Triptolide Downregulates the Expression of NRF2 Target Genes by Increasing Cytoplasmic Localization of NRF2 in A549 Cells [PDF]
Frontiers in Pharmacology, 2021 We have identified triptolide as a novel NRF2 inhibitor, which significantly attenuates ARE-luciferase activity at nanomolar concentrations. Triptolide did not affect the level of NRF2, but significantly inhibited the expression of NRF2 target genes in A549 cells.
Le Ba Nam +3 more
openaire +3 more sources
Cell Death and Disease, 2021 Nuclear factor erythroid 2-related factor 2 (Nrf2, also called NFE2L2) plays an important role in cancer chemoresistance. However, little is known about the role of Nrf2 in tumor mutation burden and the effect of Nrf2 in modulating DNA mismatch repair ...
Ping Liu +5 more
doaj +1 more source
Antioxidants, 2022 Cystathionine-y-lyase (CSE) is a critical enzyme for hydrogen sulfide (H2S) biosynthesis and plays a key role in respiratory syncytial virus (RSV) pathogenesis.
Mohammad Jamaluddin +5 more
doaj +1 more source
Frontiers in Toxicology, 2022 Engineered nanomaterials have been found to induce oxidative stress. Cellular oxidative stress, in turn, can result in the induction of antioxidant and detoxification enzymes which are controlled by the nuclear erythroid 2-related factor 2 (NRF2 ...
Sebastin Martin +26 more
doaj +1 more source