Results 21 to 30 of about 115,081 (308)

Notch-Nrf2 Axis: Regulation of Nrf2 Gene Expression and Cytoprotection by Notch Signaling [PDF]

Molecular and Cellular Biology, 2014
The Notch signaling pathway enables regulation and control of development, differentiation, and homeostasis through cell-cell communication. Our investigation shows that Notch signaling directly activates the Nrf2 stress adaptive response pathway through recruitment of the Notch intracellular domain (NICD) transcriptosome to a conserved Rbpjκ site in ...
Nobunao, Wakabayashi, John J, Skoko, Dionysios V, Chartoumpekis, Shoko, Kimura, Stephen L, Slocum, Kentaro, Noda, Dushani L, Palliyaguru, Masahiro, Fujimuro, Patricia A, Boley, Yugo, Tanaka, Norihisa, Shigemura, Shyam, Biswal, Masayuki, Yamamoto, Thomas W, Kensler   +13 more
openaire   +2 more sources

Opposing effects of Nrf2 and Nrf2‐activating compounds on the NLRP3 inflammasome independent of Nrf2‐mediated gene expression [PDF]

European Journal of Immunology, 2017
The transcription factor Nrf2 regulates the expression of genes required for protection from xenobiotic and oxidative stress. Under normal conditions Nrf2 is constantly degraded upon ubiquitination, mediated by the Nrf2 inhibitor Keap1. Inflammasomes represent stress‐induced protein complexes.
Garstkiewicz, Martha, Strittmatter, Gerhard E, Grossi, Serena, Sand, Jennifer, Fenini, Gabriele, Werner, Sabine, French, Lars E, Beer, Hans-Dietmar   +7 more
openaire   +3 more sources

NRF2 Alters Mitochondrial Gene Expression in Neonate Mice Exposed to Hyperoxia

Antioxidants, 2022
Approximately 1 in 10 newborns are born preterm and require supplemental oxygen (O2) in an extrauterine environment following birth. Supplemental O2 can induce oxidative stress that can impair mitochondrial function, resulting in lung injury and increased risk in early life pulmonary diseases.
Heather L. Vellers, Hye-Youn Cho, Wesley Gladwell, Kevin Gerrish, Janine H. Santos, Gaston Ofman, Laura Miller-DeGraff, T. Beth Mahler, Steven R. Kleeberger   +8 more
openaire   +3 more sources

Functional Role of NRF2 in Cervical Carcinogenesis. [PDF]

PLoS ONE, 2015
Nuclear factor erythroid-2-related factor 2 (NFE2L2) is a transcription factor associated with resistance to chemotherapy and increased tumor growth. NRF2 is repressed by the inhibitor Keap1.
Jun-Qi Ma, Hatila Tuersun, Shu-Juan Jiao, Jian-He Zheng, Jing-Bao Xiao, Ayshamgul Hasim   +5 more
doaj   +1 more source

NRF2/HO-1 axis, BIRC5, and TP53 expression in ESCC and its correlation with clinical pathological characteristics and prognosis

The International Journal of Biological Markers, 2023
Background Many types of cancer exhibit high nuclear factor erythroid 2-related factor 2 (NRF2), which is effective in resisting drugs and radiation.
Yongmei Gao, Li Wan, Mengyan Li, Bo Wang, Yuqing Ma   +4 more
doaj   +1 more source

Nrf2 Regulates Anti-Inflammatory A20 Deubiquitinase Induction by LPS in Macrophages in Contextual Manner

Antioxidants, 2021
The aberrant regulation of inflammatory gene transcription following oxidant and inflammatory stimuli can culminate in unchecked systemic inflammation leading to organ dysfunction.
Haranatha R. Potteti, Lalith K. Venkareddy, Patrick M. Noone, Aparna Ankireddy, Chandramohan R. Tamatam, Dolly Mehta, Chinnaswamy Tiruppathi, Sekhar P. Reddy   +7 more
doaj   +1 more source

Emerging role of nuclear factor erythroid 2-related factor 2 in the mechanism of action and resistance to anticancer therapies [PDF]

, 2019
Nuclear factor E2-related factor 2 (NRF2), a transcription factor, is a master regulator of an array of genes related to oxidative and electrophilic stress that promote and maintain redox homeostasis. NRF2 function is well studied in in vitro, animal and
Deeni, Yusuf Y., Kankia, Ibrahim H., Langdon, Simon P., Paramasivan, Poornima   +3 more
core   +3 more sources

Stress Resistance Screen in a Human Primary Cell Line Identifies Small Molecules That Affect Aging Pathways and Extend Caenorhabditis elegans' Lifespan. [PDF]

, 2020
Increased resistance to environmental stress at the cellular level is correlated with the longevity of long-lived mutants and wild-animal species. Moreover, in experimental organisms, screens for increased stress resistance have yielded mutants that are ...
Ang, Kenny Kean-Hooi, Arkin, Michelle, Cregg, James, Kenyon, Cynthia, Zhai, Yuying, Zhang, Peichuan   +5 more
core   +2 more sources

Nrf2-DEPENDENT GENE EXPRESSIONS: A MOLECULAR TOXICOLOGICAL ASPECT

The Journal of Toxicological Sciences, 2004
Although NF-E2 related factor 2 (Nrf2) was found to be a transcriptional regulator that controls an expression of the beta-globin gene, the notion is now widely accepted that this transfactor serves as a master regulator for the gene expression of a battery of proteins acting on anti-oxidative stress and detoxification of electrophiles. The function of
Satoshi, Numazawa, Takemi, Yoshida
openaire   +3 more sources

Differential expression of the Nrf2-linked genes in pediatric septic shock [PDF]

Critical Care, 2015
Abstract Introduction Experimental data from animal models of sepsis support a role for a transcription factor, nuclear erythroid-related factor 2 p45-related factor 2 (Nrf2), as a master regulator of antioxidant and detoxifying genes and intermediary metabolism during stress.
Grunwell, Jocelyn R., Weiss, Scott L., Cvijanovich, Natalie Z., Allen, Geoffrey L., Thomas, Neal J., Freishtat, Robert J., Anas, Nick, Meyer, Keith, Checchia, Paul A., Shanley, Thomas P., Bigham, Michael T., Fitzgerald, Julie, Howard, Kelli, Frank, Erin, Harmon, Kelli, Wong, Hector R.   +15 more
openaire   +2 more sources