Results 21 to 30 of about 80,339 (259)
MiR-144 Regulates Hemoglobin Expression in Human Erythroid Cell Line
Walailak Journal of Science and Technology, 2020 The regulation of globin gene expression is significantly important to understand the pathogenesis of globin gene disorders. Recent findings have shown that microRNAs (miRNAs, miRs) play an important role in the regulation of globin gene expression. The
Tipparat PENGLONG +5 more
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Redox Biology, 2014 Cytochrome P450 gene expression is altered by various chemical compounds. In this study, we used nuclear factor erythroid 2-related factor 2 (Nrf2)–deficient (Nrf2−⧸−) mice to investigate the involvement of Nrf2 in Cyp2b10 and Cyp2a5 gene expression ...
Takashi Ashino +4 more
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Aquaculture and Fisheries, 2018 Nuclear factor erythroid 2-related factor 2 (Nrf2) is an important transcription factor in the regulation of redox homeostasis, which plays a vital role in metabolism, the cell cycle, and cell protection. In this study, the complete cDNA sequence of Nrf2
Junpeng Wang +8 more
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NRF2 Alters Mitochondrial Gene Expression in Neonate Mice Exposed to Hyperoxia
Antioxidants, 2022 Approximately 1 in 10 newborns are born preterm and require supplemental oxygen (O2) in an extrauterine environment following birth. Supplemental O2 can induce oxidative stress that can impair mitochondrial function, resulting in lung injury and increased risk in early life pulmonary diseases.
Heather L. Vellers +8 more
openaire +3 more sources
Mining a human transcriptome database for chemical modulators of NRF2.
PLoS ONE, 2020 Nuclear factor erythroid-2 related factor 2 (NRF2) encoded by the NFE2L2 gene is a transcription factor critical for protecting cells from chemically-induced oxidative stress.
John P Rooney +7 more
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Regulation of Nrf2 by Mitochondrial Reactive Oxygen Species in Physiology and Pathology
Biomolecules, 2020 Reactive oxygen species (ROS) are byproducts of aerobic respiration and signaling molecules that control various cellular functions. Nrf2 governs the gene expression of endogenous antioxidant synthesis and ROS-eliminating enzymes in response to various ...
Shuya Kasai +4 more
doaj +1 more source
Chinese Journal of Lung Cancer, 2018 Background and objective There are significantly interindividual variations of the expression level of nuclear factor erythroid-2-related factor 2 (Nrf2) and/or Kelch-like ECH-associated protein 1 (Keap1) in our previous studies.
Yu XIAO +5 more
doaj +1 more source
Glucose availability is a decisive factor for Nrf2-mediated gene expression
Redox Biology, 2013 Activation of the transcription factor Nrf2 (nuclear factor-erythroid 2-related factor 2) is one of the major cellular defense lines against oxidative and xenobiotic stress, but also influences genes involved in lipid and glucose metabolism. It is unresolved whether the cytoprotective and metabolic responses mediated by Nrf2 are connected or separable ...
Heiss, Elke H. +3 more
openaire +5 more sources
Antioxidants, 2020 Background: While reperfusion is crucial for survival after an episode of ischemia, it also causes oxidative stress. Nuclear factor-E2-related factor 2 (Nrf2) and unfolded protein response (UPR) are protective against oxidative stress and endoplasmic ...
Denise Peserico +6 more
doaj +1 more source
Chinese Journal of Lung Cancer, 2014 Background and objective Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have become first-line treatment drugs for lung adenocarcinoma patients with EGFR gene mutations.
Xiang ZHU +5 more
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