Results 231 to 240 of about 78,211 (259)

The Keap1-Nrf2 Signaling Pathway in Lung Cancer

2021
The survival and proliferation of lung cancers widely depend on various signaling pathways; Keap1-Nrf2-ARE is one of the primary pathways in lung cancers. The principal function of Nrf2 is to offer protection to cells from stress induced by xenobiotics through the activation of cytoprotective transcriptional programs.
Azhwar Raghunath, Raju Nagarajan, Kiruthika Sundarraj   +2 more
openaire   +1 more source

Nrf2 signaling pathway: focus on oxidative stress in osteoporosis

Osteoporosis International
The nuclear factor erythrocyte 2-related factor-2 (Nrf2) signaling pathway is an important regulatory factor for bone homeostasis in osteoporosis. It is also regarded as a key pathway of antioxidant stress and is closely related to the pathological process of osteoporosis.
Hou-Yun, Gu, Ning, Liu, Fei-Xiang, Lin, Jun, Yin   +3 more
openaire   +2 more sources

Coordination of ER and oxidative stress signaling: The PERK/Nrf2 signaling pathway

The International Journal of Biochemistry & Cell Biology, 2006
In the broadest sense, cellular stress describes conditions wherein cells encounter and react to a 'non-normal' state. Perturbations may originate through both extracellular and intracellular means. Whereas transient levels of stress are expected to occur on a regular basis, a series of checks and balances ensures that cells are well equipped to ...
Sara B, Cullinan, J Alan, Diehl
openaire   +2 more sources

Lights and Shadows of Electrophile Signaling: Focus on the Nrf2-Keap1 Pathway

Future Medicinal Chemistry, 2019
Targeted covalent modification is assuming consolidated importance in drug discovery. In this context, the electrophilic tuning of redox-dependent cell signaling is attracting major interest, as it opens prospect for treating numerous pathologic conditions.
Basagni F., Lanni C., Minarini A., Rosini M.   +3 more
openaire   +4 more sources

Activation of Nrf2-ARE signal pathway in hippocampus of amygdala kindling rats

Neuroscience Letters, 2013
Oxidative stress resulting from excessive free-radical release is likely implicated in the initiation and progression of epilepsy. Therefore, antioxidant therapies have received considerable attention in epilepsy treatment. It is well known that the transcription factor NF-E2-related factor (Nrf2) binds to antioxidant response element (ARE) to induce ...
Wei, Wang, Wei-Ping, Wang, Guo-Liang, Zhang, Yan-Fen, Wu, Tao, Xie, Min-Chen, Kan, Hai-Bo, Fang, Hong-Chao, Wang   +7 more
openaire   +2 more sources

The role of Nrf2 signaling pathways in nerve damage repair

Toxicology Research
AbstractThe protein, Nuclear factor-E2-related factor 2 (Nrf2), is a transitory protein that acts as a transcription factor and is involved in the regulation of many cytoprotective genes linked to xenobiotic metabolism and antioxidant responses. Based on the existing clinical and experimental data, it can be inferred that neurodegenerative diseases are
Arash Abdolmaleki, Aida Karimian, Seyedeh Mahdieh Khoshnazar, Asadollah Asadi, Zahra Akhavi Samarein, Shukur Wasman Smail, Deepak Bhattacharya   +6 more
openaire   +2 more sources

Luteolin inhibits the Nrf2 signaling pathway and tumor growth in vivo

Biochemical and Biophysical Research Communications, 2014
Nuclear factor erythroid 2-related factor 2 (Nrf2) is over-expressed in many types of tumor, promotes tumor growth, and confers resistance to anticancer therapy. Hence, Nrf2 is regarded as a novel therapeutic target in cancer. Previously, we reported that luteolin is a strong inhibitor of Nrf2 in vitro.
Song, Chian, Ruby, Thapa, Zhexu, Chi, Xiu Jun, Wang, Xiuwen, Tang   +4 more
openaire   +2 more sources

Therapeutic and biological activities of berberine: The involvement of Nrf2 signaling pathway

Journal of Cellular Biochemistry, 2019
Abstract Since the beginning of the 21st century, studies have focused on developing drugs from naturally occurring compounds. Berberine (Brb) as a plant‐derived compound is of interest. It is an isoquinone alkaloid which is derived from Berberis aristata, Berberis aquifolium and Berberis vulgaris.
Milad Ashrafizadeh, Hojjat Samareh Fekri, Zahra Ahmadi, Tahereh Farkhondeh, Saeed Samarghandian   +4 more
openaire   +2 more sources

The Power of Daphnetin: Enhancing Nrf2 Signaling Pathway

Life Sciences Student Journal
Chronic inflammation and oxidative stress are involved in a range of diseases. The Nrf2 pathway is crucial in controlling cellular defenses against stresses. Daphnetin (DAP), a compound derived from plants such as Daphne odora, has shown promise to activate Nrf2, a protein with potential therapeutic uses.
Modarresi Chahardehi, Amir, Jamshidi, Negar, Jamshidi, Nazanin, Ghasemi, Darioush, Modarresi, Farrokh   +4 more
openaire   +1 more source

Hydroxygenkwanin exerts a neuroprotective effect by activating the Nrf2/ARE signaling pathway

Food and Chemical Toxicology
High levels of reactive oxygen species (ROS) have been associated with the progression of neurodegenerative diseases such as Alzheimer's disease. The activation of the NFE2-related factor 2 (Nrf2)/antioxidant response element (ARE) signaling pathway may restore the neuron's redox balance and provide a therapeutic impact.
Alsiddig Osama, Jun Wu, Qiuying Nie, Zi-Long Song, Linjie Zhang, Jia Gao, Baoxin Zhang   +6 more
openaire   +2 more sources