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The Effects of Ginsenosides on the Nrf2 Signaling Pathway
2021Nuclear factor erythroid-2 related factor 2 (Nrf2) is a major signaling pathway for the maintenance of homeostasis and redox balance. This pathway also plays a significant role in proteostasis, xenobiotic/drug metabolism, apoptosis, and lipid and carbohydrate metabolism.
Ashrafizadeh, Milad +5 more
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The Nrf2-Keap1/ARE signaling pathway in aquatic animals
International Journal of Biological MacromoleculesThe complex and fluctuating conditions of aquatic ecosystems make aquatic organisms vulnerable to oxidative stress. The Nrf2-Keap1/ARE signaling pathway serves as an important intracellular defense mechanism, particularly for aquatic organisms exposed to environmental stressors and toxic substances.
Bo-Ping Tang, Qiu-Ning Liu
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The Study of Nrf2 Signaling Pathway in Ovarian Cancer
Critical Reviews in Eukaryotic Gene Expression, 2018Ovarian cancer is one of the most malignant gynecological tumors in the world, with a high fatality rate and resistance to chemotherapy. Much basic research has revealed that oxidative stress is involved in tumor occurrence and development processes and is associated with tumor progression as well as metastasis.
Xiaotong, Wu +3 more
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Nrf2 as a converging node for cellular signaling pathways of gasotransmitters
Medical Hypotheses, 2012Gasotransmitters is a family of endogenous molecules of gases or gaseous signaling molecules. To date, nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H(2)S) have been found to be important gasotransmitters in humans. Three gasotransmitters at high concentrations have been confirmed to be detrimental to human health, while evidence shows ...
Wenwu, Liu +3 more
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Keap1‐Nrf2 signaling pathway in angiogenesis and vascular diseases
Journal of Tissue Engineering and Regenerative Medicine, 2020The transcription factor, nuclear factor E2-related factor 2 (Nrf2), is highly sensitive to oxidative burst products, including reactive oxygen species (ROS) and reactive nitrogen species. In the cell nucleus, Nrf2 activates various antioxidant genes by binding to the antioxidant response elements.
Zi Guo, Zhaohui Mo
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Targeting Keap1/Nrf2/ARE signaling pathway in multiple sclerosis
European Journal of Pharmacology, 2020Multiple sclerosis (MS) is a neurologic autoimmune disorder featured by chronic inflammation of the central nervous system, demyelination and axonal damage. Recently, the term "oxinflammation" has been proposed to depict the vicious circle of chronic inflammation and oxidative stress (OS).
Danica, Michaličková +3 more
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Mechanistic Studies of the Nrf2-Keap1 Signaling Pathway
Drug Metabolism Reviews, 2006Since eukaryotic cells constantly encounter various environmental insults, they have evolved defense mechanisms to cope with toxicant- and carcinogen-induced oxidative stress or electrophiles. One of the most important cellular defense mechanisms against oxidative stress or electrophiles is mediated by the transcription factor Nrf2.
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A strategy for cancer prevention: Stimulation of the Nrf2-ARE signaling pathway
Molecular Cancer Therapeutics, 2004AbstractMany genes, with products involved in the protection of cells against carcinogens, oxidants, and other toxic chemicals, are under the transcriptional control of a simple DNA regulatory element [i.e., the antioxidant response element (ARE)]. One or more functional AREs have been confirmed or are believed to exist in the upstream region of many ...
Yuesheng, Zhang, Gary B, Gordon
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The Nrf2-Keap1-ARE Signaling Pathway: The Regulation and Dual Function of Nrf2 in Cancer
Antioxidants & Redox Signaling, 2010The NF-E2-related factor-2 (Nrf2) is a transcription factor that is ubiquitously expressed at low levels in all human organs. As Nrf2 regulates a major cellular defense mechanism, tight regulation is crucial to maintain cellular homeostasis. Activation of this pathway is important in preventing human diseases, such as cancer, neurodegenerative disease,
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Nrf2–ARE signaling pathway and natural products for cancer chemoprevention
Cancer Epidemiology, 2010One of the potential strategies for preventing cancers is using food-based natural products to induce cytoprotective enzymes including phase II and antioxidative enzymes that act in concert to detoxify and eliminate harmful reactive intermediates formed from carcinogens.
Cui Rong, Zhao +2 more
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