Results 111 to 120 of about 15,068 (213)

Neuropilin1-dependent paracrine signaling of cancer cells mediated by miRNA exosomal cargo

Cell Communication and Signaling
Background Neuropilin-1 (NRP1) is a transmembrane protein involved in surface receptor complexes for a variety of extracellular signals. NRP1 expression in human cancers is associated with prominent angiogenesis and advanced progression stage.
Claudia Palazzo, Roberta Mastrantonio, Noemi Gioelli, Erika Testa, Francesco Recco, Donatella Lucchetti, Giulia Villari, Alessio D’Alessio, Alessandro Sgambato, Flavio Mignone, Guido Serini, Maria Teresa Viscomi, Luca Tamagnone   +12 more
doaj   +1 more source

Nrp1 selectively inhibits VEGF-A binding.

, 2012
The ability of Nrp1 and Nrp2 to selectively sequester AP-VEGF-A from Nrp1 adsorbed on affinity plates was assessed. The amount of retained AP-VEGF-A was measured and the Nrp concentration recorded where half-inhibition was achieved.
Hou-Fu Guo (122621), Ping Xu (122619), Craig W. Vander Kooi (122623), Matthew W. Parker (122616)   +3 more
core   +1 more source

Single cell knockout of NRP1 in neural progenitors results in neurons with impaired dendritic formations is independent of vascular endothelial growth factor (VEGF)-binding of NRP1.

, 2013
(A) Graphs showing quantification of total dendritic length (A) and branch number (B) of newborn DGCs expressing GFP (CTR) or Cre-recombinase (CRE) at 14 DPI in NRP1 conditional knockout mice (NRP1 Floxed/Floxed) or mice expressing one single copy of ...
Jae Ho Sohn (420043), Terence Tan (420044), Eyleen L. K. Goh (310970), Guo-li Ming (265101), Hongjun Song (420045), Jae Ryun Ryu (310967), Teclise Ng (420042)   +6 more
core   +1 more source

NRP1 and NRP2 are expressed in adult neural progenitor cells and can be knocked down by NRP1 and NRP2 shRNA respectively.

, 2013
(A) Representative western blots showing that NRP1 and NRP2 are expressed in cortical and hippocampal primary neuronal culture and adult hippocampal neural progenitor cells (NPCs). HEK 293 cells were overexpressed with NRP1 (‘+’, upper panel) and NRP2 (‘+
Jae Ho Sohn (420043), Terence Tan (420044), Eyleen L. K. Goh (310970), Guo-li Ming (265101), Hongjun Song (420045), Jae Ryun Ryu (310967), Teclise Ng (420042)   +6 more
core   +1 more source

NRP1 acts cell autonomously in endothelium to promote tip cell function during sprouting angiogenesis

, 2013
Neuropilin (NRP) 1 is a receptor for the vascular endothelial growth factor (VEGF)-A and is essential for normal angiogenesis. Previous in vitro experiments identified NRP1 interactions with VEGF-A's main signaling receptor VEGFR2 within endothelial ...
Fantin A, Vieira JM, Pollard JW, Plein A, Ruhrberg C, Fruttiger M, Denti L   +6 more
core   +2 more sources

Neuropilin 1 is essential for gastrointestinal smooth muscle contractility and motility in aged mice.

PLoS ONE, 2015
Background and aimsNeuropilin 1 (NRP1) is a non-tyrosine kinase receptor for vascular endothelial growth factor (VEGF) and class 3 semaphorins, playing a role in angiogenesis and neuronal axon guidance, respectively.
Maiko Yamaji, Marwa Mahmoud, Ian M Evans, Ian C Zachary   +3 more
doaj   +1 more source

Neuropilin-1: A Conserved Entry Receptor for SARS-CoV-2 and a Potential Therapeutic Target

Biomedicines
Background/Objectives: Neuropilin-1 (NRP1) is a key co-receptor for SARS-CoV-2, complementing the ACE2 receptor. Several investigations have documented highly conserved sequences in this receptor, supporting the implication of NRP1 as a key mediator in ...
Vivany Maydel Sierra-Sánchez, Citlali Margarita Blancas-Napoles, Aina Daniela Sánchez-Maldonado, Indira Medina, Rodrigo Romero-Nava, Fengyang Huang, Enrique Hong, Asdrúbal Aguilera-Méndez, Sergio Adrian Ocampo-Ortega, Santiago Villafaña   +9 more
doaj   +1 more source

SMC-specific knockout of Nrp1 leads to defects in smooth muscle morphology.

, 2015
(A) SMA immunohistochemistry on cross-sections of adult colon (≥18 months).
Maiko Yamaji (689767), Ian C. Zachary (121627), Marwa Mahmoud (572666), Ian M. Evans (689768)   +3 more
core   +1 more source

Insilico targeting of virus entry facilitator NRP1 to block SARS-CoV2 entry.

PLoS ONE
The entry and infectivity of a virus are determined by its interaction with the host. SARS-CoV-2, the virus responsible for COVID-19, utilizes the spike (S) protein to attach to and enter host cells.
Nousheen Bibi, Maleeha Shah, Shahzad Khan, Muhammad Shahzad Chohan, Mohammad Amjad Kamal   +4 more
doaj   +1 more source

NRP1 is a Prognostic Factor and Promotes the Growth and Migration of Cells in Intrahepatic Cholangiocarcinoma

Cancer Management and Research, 2020
Yong-Na Wu,1– 4,* Li-Hong He,1,2,5,* Zhong-Tian Bai,1,2,5,* Xun Li1,2,5 1Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, People’s Republic of China; 2Key Laboratory of Biological ...
Wu YN, He LH, Bai ZT, Li X
doaj