Results 81 to 90 of about 13,650 (179)

Neutrophils Promote Metabolic Dysfunction‐Associated Steatotic Liver Disease Through Extracellular Vesicle‐mediated Lipid Transfer

Journal of Extracellular Vesicles, Volume 15, Issue 8, August 2026.
Neutrophils acquire extracellular fatty acids or adipocyte‐derived lipids and store them as triglycerides, polarizing into a lipid‐laden phenotype. Lipid‐laden neutrophils are found in the peripheral blood of HFD‐fed mice and patients with MASLD. These neutrophils release extracellular vesicles enriched with triglycerides and microRNAs that deliver ...
Sanjeeb Shrestha, Soo‐Jung Jung, Seong‐Min Lim, Yu‐Bin Lee, Hyeung‐Wook Shin, Hoyul Lee, Hee‐Kyung Jin, Jae‐Sung Bae, Jae‐Han Jeon, Lai Guan Ng, Chang‐Won Hong   +10 more
wiley   +1 more source

NRP1 expression is associated with chemosensitivity and poor prognosis in advanced non-small cell lung cancer patients treated with first-line platinum-based chemotherapy

Zhongguo aizheng zazhi, 2016
Background and purpose: Neuropilin-1 (NRP1), a vascular endothelial growth factor (VEGF) receptor, plays an important role in tumor angiogenesis and tumor cell migration.
冯卫能, 张良运, 石海燕
doaj  

In‐Vitro Evaluation of HIV/SARS‐CoV‐2 Co‐Infection Mediated Proteomic Changes in Astrocytes and Pericytes Reveals Altered Signaling Pathways Associated With Neurodegenerative Disorders

Journal of Medical Virology, Volume 98, Issue 8, August 2026.
ABSTRACT Coronavirus disease 2019 (COVID‐19) survivors frequently experience a wide range of symptoms known as post‐acute sequelae of SARS‐CoV‐2 (PASC) or long COVID. Importantly, complications arising from microvascular dysfunction, blood‐brain barrier (BBB) disruption, and chronic neuroinflammation have been implicated in driving PASC within the ...
Arpan Acharya, Michellie Thurman, Debapriya Sutar, Oluwatayo Israel Olasunkanmi, Johid R. Malik, Shetty Ravi Dyavar, Ákos Végvári, Siddappa N. Byrareddy   +7 more
wiley   +1 more source

Proteomic and Phosphoproteomic Characteristics of Multiple Brain Regions in Rhesus Macaques After SARS‐CoV‐2 Infection

MedComm, Volume 7, Issue 8, August 2026.
The study found that SARS‐CoV‐2 Omicron infection causes region‐specific inflammatory, immune, synaptic, and signaling disorders in the brain, and the predicted kinases and differentially expressed proteins may serve as potential targets for COVID‐19‐related drug discovery.
Qiaochu Wang, Yanan Zhou, Tao Ding, Yan Sun, Yehong Yang, Yue Wu, Jiangfeng Liu, Shuaiyao Lu, Juntao Yang   +8 more
wiley   +1 more source

Neuropilin-1 inhibition suppresses nerve growth factor signaling and nociception in pain models

The Journal of Clinical Investigation
Nerve growth factor (NGF) monoclonal antibodies inhibit chronic pain, yet failed to gain approval due to worsened joint damage in osteoarthritis patients.
Chloe J. Peach, Raquel Tonello, Elisa Damo, Kimberly Gomez, Aida Calderon-Rivera, Renato Bruni, Harsh Bansia, Laura Maile, Ana-Maria Manu, Hyunggu Hahn, Alex R.B. Thomsen, Brian L. Schmidt, Steve Davidson, Amedee des Georges, Rajesh Khanna, Nigel W. Bunnett   +15 more
doaj   +1 more source

Lower Respiratory Microbiome Dysbiosis Is Associated With Poor Prognosis in Acute Severe Lower Respiratory Tract Infection

MedComm, Volume 7, Issue 8, August 2026.
Acute severe lower respiratory tract infection (asLRTI) present lower alpha‐diversity in lower respiratory tract microbiome (LRTM). Five clusters (C1–C5) were grouped, and cluster C3 was strongly associated with poor prognosis and reduced survival.
Minghua Zhan, Hongbin Chen, Ziyao Li, Si Liu, Binghuai Lu, Zhang Wang, Hui Wang   +6 more
wiley   +1 more source

A noncanonical role for Jagged1 in endothelial mechanotransduction

The FEBS Journal, Volume 293, Issue 15, Page 4604-4623, August 2026.
The Notch signaling pathway plays a crucial role in regulating endothelial biology. Notch signaling is sensitive to hemodynamic forces and governs mechanically driven cardiovascular development, physiology, and remodeling. This study reveals a non‐canonical role for the Notch ligand Jagged1 in endothelial mechanotransduction.
Freddy Suarez Rodriguez, Noora Virtanen, Elmeri Kiviluoto, Rob C. H. Driessen, Feihu Zhao, Carlijn V. C. Bouten, Oscar M. J. A. Stassen, Cecilia M. Sahlgren   +7 more
wiley   +1 more source

Neuropilin-1 serves as a prognostic marker and a potential target of M2-polarized tumor-associated macrophages in gastric cancer

Immunobiology
Neuropilin-1 (NRP1) has recently emerged as a promising immune checkpoint. However, its prognostic significance in gastric cancer (GC) and its association with the tumor immune microenvironment remain insufficiently understood. In this study, analysis of
Jingya Wang, Cheng Lan, Zhebo Xia, Dawei Cui, Hang Lv, Na Qiang, Guiping Chen, Junjie Ao   +7 more
doaj   +1 more source

NRP1 como potencial alvo molecular para meduloblastoma

BioSCIENCE
Introdução: Meduloblastoma é tumor maligno, altamente agressivo e de rápido crescimento que surge no cerebelo ou no assoalho do quarto ventrículo e tronco cerebral, especialmente em crianças. Mesmo com avanços na terapia, a morbimortalidade permanece grande desafio. Por isso, novos tratamentos são necessários para reduzir esses desfechos.
Moisés Augusto De Araujo, Paulo Afonso Nunes Nassif, Livia Fratini, Rafael Roesler, Samuel Rabello, Alexsandro Batista da Costa Carmo, Gustavo Rassier Isolan   +6 more
openaire   +1 more source

Neuropilin-1 expression is associated with lymph node metastasis in breast cancer tissues

Cancer Management and Research, 2018
Mahnaz Seifi-Alan,1 Roshanak Shams,1 Mojgan Bandehpour,2 Reza Mirfakhraie,1 Soudeh Ghafouri-Fard1 1Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Department of Biotechnology, School of Advanced Technologies
Seifi-Alan M, Shams R, Bandehpour M, Mirfakhraie R, Ghafouri-Fard S   +4 more
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