Results 71 to 80 of about 13,650 (179)

PLGF/NRP1 Signaling Is Critical for Medulloblastoma Growth [PDF]

Cancer Discovery, 2013
Abstract PlGF signaling through NRP1 but not VEGFR1 promotes pediatric medulloblastoma cell survival.
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NRP1 transport of cancer therapeutics mediated by tumor-penetrating peptides [PDF]

Drugs of the Future, 2017
Whereas uptake of low molecular weight agents is generally inhibited in tumors due to high interstitial pressure, tumor uptake of macromolecules is increased due to enhanced permeability and retention (EPR). Small molecule drugs alone or incorporated in nanoparticles (NP) have largely been dependent on such physical tumor uptake (passive) for ...
Qixin, Leng, Martin C, Woodle, A James, Mixson   +2 more
openaire   +2 more sources

STAT6 Upregulates NRP1 Expression in Endothelial Cells and Promotes Angiogenesis

Frontiers in Oncology, 2022
The role of signal transducer and activator of transcription 6 (STAT6) in tumor growth has been widely recognized. However, its effects on the regulation of angiogenesis remain unclear. In this study, we found that STAT6 promoted angiogenesis, possibly by increasing the expression of neuropilin-1 (NRP1) in endothelial cells (ECs). Both STAT6 inhibitor (
Peng Gao, Peng Gao, Guanghui Ren, Jiangjiu Liang, Ju Liu   +4 more
openaire   +3 more sources

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

scRNA‐Seq in Gastric Cancer Reveals Macrophage‐Derived C1q as a Diagnostic Marker

Cancer Science, EarlyView.
Single‐cell sequencing of GC analyzed the tumor microenvironment and discovered the C1QA+ TAMs subpopulation with immunosuppressive function. The role of C1q in the prognosis and diagnosis of GC was demonstrated through plasma and tumor tissue from the GC cohort.
Saisai Gong, Yupeng Zhao, Sheng Yang, Tong Liu, Chengyun Li, Yun Zhou, Geyu Liang   +6 more
wiley   +1 more source

SGLT‐2 Inhibitors are Associated With a Lower Risk of Multiple Myeloma

European Journal of Haematology, EarlyView.
ABSTRACT Aims We aimed to investigate drug response of sodium‐glucose transport protein‐2 inhibitors (SGLT2i) in multiple myeloma (MM), as SGLT2i have potential favorable effects on conditions related to MM. Methods We conducted a pharmacoepidemiologic study with a US nationwide health insurance claim data using Cox models to investigate the ...
Enze Liu, Anna Sun, Yuedi Yang, Jing Xu, Attaya Suvannasankha, Brian A. Walker, Pengyue Zhang   +6 more
wiley   +1 more source

Transcriptomic profiling of subpopulations of mouse embryonic subplate neurons

Journal of Anatomy, EarlyView.
To study gene expression in subpopulations of cortical subplate neurons (Lpar1‐EGFP‐positive and D1B‐positive SpN clusters), we applied gene expression profiling, including bulk microarray analysis, single‐cell RNA sequencing (scRNA‐seq), and Visium spatial transcriptomics, and identified both overlapping and unique gene expression signatures ...
Hitomi Achiwa, Yuichiro Hara, Hideya Kawaji, Minori Oshima, Noe Kaneko, Ayumu Morioka, Anna Hoerder‐Suabedissen, Zoltán Molnár, Chiaki Ohtaka‐Maruyama   +8 more
wiley   +1 more source

New perspectives on VEGF signalling in Alzheimer's disease

Brain Pathology, Volume 36, Issue 5, September 2026.
Emery et al. bring together findings from recent multi‐omic studies, including single‐cell mRNA analysis of human post‐mortem brain tissue, and proteomic analysis of matched CSF and blood samples in large clinical studies. The authors present evidence of the involvement of altered VEGF signalling in vascular and immune dysfunction and neurodegeneration
Cherelle E. G. Emery, Seth Love, J. Scott Miners   +2 more
wiley   +1 more source

Endothelial Function Is Associated With Incident Diabetes Mellitus: The ELSA‐Brasil Cohort Study

Diabetes, Obesity and Metabolism, Volume 28, Issue 9, Page 8103-8112, September 2026.
ABSTRACT Aims Diabetes mellitus is associated with endothelial dysfunction, but the bidirectional nature of this relationship remains debated. We aimed to evaluate the association between microvascular endothelial function and incident diabetes in Brazilian adults and to assess potential effect modification by obesity status.
Karina P. M. P. Martins, Sandhi M. Barreto, Lidyane V. Camelo, Sara T. Menezes, Naomi M. Hamburg, Maria de Fatima H. S. Diniz, Antonio L. P. Ribeiro, Luisa C. C. Brant   +7 more
wiley   +1 more source

Venom‐Derived Bioactive Peptides: From Toxins to Therapeutics

Advanced Therapeutics, Volume 9, Issue 8, August 2026.
Venomics → Target Identification → Peptide Optimization → Therapeutic Translation Bioactive venom peptides targeting ion channels, enzymes, and receptors drive the development of next‐generation precision therapeutics. ABSTRACT Venoms are complex biochemical mixtures composed of diverse bioactive components, including proteins, enzymes, small molecules,
Eldho Sabu, Othman Al Musaimi
wiley   +1 more source