Results 61 to 70 of about 15,068 (213)
Biology Open, 2015 Neuropilin-1 (NRP1) has been identified as a VEGF-A receptor. DJM-1, a human skin cancer cell line, expresses endogenous VEGF-A and NRP1. In the present study, the RNA interference of VEGF-A or NRP1 suppressed DJM-1 cell proliferation.
Ayumi Yoshida +8 more
doaj +1 more source
Advanced Science, EarlyView.In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen +19 more
wiley +1 more source
NRP1 transport of cancer therapeutics mediated by tumor-penetrating peptides [PDF]
Drugs of the Future, 2017 Whereas uptake of low molecular weight agents is generally inhibited in tumors due to high interstitial pressure, tumor uptake of macromolecules is increased due to enhanced permeability and retention (EPR). Small molecule drugs alone or incorporated in nanoparticles (NP) have largely been dependent on such physical tumor uptake (passive) for ...
Qixin, Leng +2 more
openaire +2 more sources
VEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration, complex formation between NRP1 and VEGFR2, and signaling via FAK Tyr407 phosphorylation [PDF]
, 2011 In endothelial cells, neuropilin-1 (NRP1) binds vascular endothelial growth factor (VEGF)-A and is thought to act as a coreceptor for kinase insert domain-containing receptor (KDR) by associating with KDR and enhancing VEGF signaling.
Hartzoulakis, B +9 more
core +1 more source
USP9X-mediated NRP1 deubiquitination promotes liver fibrosis by activating hepatic stellate cells
Cell Death and Disease, 2023 Liver fibrosis is a complex fibrotic process that develops early in the course of cirrhosis and is caused by chronic liver damage. The activation of hepatic stellate cells is primarily responsible for the fibrosis process.
Jinqiu Zhao +5 more
doaj +1 more source
Advanced Science, EarlyView.A supramolecular nanocomplex based on phenolic‐modified silk sericin is developed to deliver antioxidant enzymes across the blood–brain barrier and escape lysosomal degradation. This dual‐barrier‐crossing system reduces neuroinflammation and improves cognitive performance in Alzheimer's disease mouse model, offering a promising strategy for protein ...
Doudou Hu +5 more
wiley +1 more source
Image_4_STAT6 Upregulates NRP1 Expression in Endothelial Cells and Promotes Angiogenesis.tif
, 2022 The role of signal transducer and activator of transcription 6 (STAT6) in tumor growth has been widely recognized. However, its effects on the regulation of angiogenesis remain unclear.
Guanghui Ren (4229440) +3 more
core +1 more source
Characterization of peptide binding to the SARS-CoV-2 host factor neuropilin
Heliyon, 2021 The ongoing coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global health concern.
Amie Jobe, Ranjit Vijayan
doaj +1 more source
Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges
BMEMat, EarlyView.This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma +8 more
wiley +1 more source
Image_2_STAT6 Upregulates NRP1 Expression in Endothelial Cells and Promotes Angiogenesis.tif
, 2022 The role of signal transducer and activator of transcription 6 (STAT6) in tumor growth has been widely recognized. However, its effects on the regulation of angiogenesis remain unclear.
Guanghui Ren (4229440) +3 more
core +1 more source