Results 51 to 60 of about 15,068 (213)
NRP1-FS and NRP1-Δ7 are differentially relocalized after VEGF-A165 stimulation.
, 2016 PC3 clones induced (dox at 200 ng/ml) to express FLAG-tagged NRP1-FS or NRP1-Δ7 were serum-starved for 24h before exposure or not to VEGF-A165 for 10 minutes.
Céline Hendricks (3307878) +5 more
core +1 more source
Image_8_STAT6 Upregulates NRP1 Expression in Endothelial Cells and Promotes Angiogenesis.tif
, 2022 The role of signal transducer and activator of transcription 6 (STAT6) in tumor growth has been widely recognized. However, its effects on the regulation of angiogenesis remain unclear.
Guanghui Ren (4229440) +3 more
core +1 more source
NRP1-Δ7 is expressed in various cell types and tissues.
, 2016 RT-PCR analysis was performed on total RNA extracted from cells and tissues from human (A) and mouse (B) origin as detailed in Materials and Methods. The higher molecular weight product of 233bp is amplified from NRP1-FS (FS) while the lower molecular ...
Céline Hendricks (3307878) +5 more
core +1 more source
Image_3_STAT6 Upregulates NRP1 Expression in Endothelial Cells and Promotes Angiogenesis.tif
, 2022 The role of signal transducer and activator of transcription 6 (STAT6) in tumor growth has been widely recognized. However, its effects on the regulation of angiogenesis remain unclear.
Guanghui Ren (4229440) +3 more
core +1 more source
NRP1-Δ7 reduces cancer cell proliferation in vitro.
, 2016 Doxycycline-inducible PC3 and MDA-MB-231 cells able to express recombinant NRP1-FS (FS) or NRP1-Δ7 (Δ7) were seeded in 24-well plates in presence (dotted lines) or absence (continuous lines) of 200 ng/ml doxycycline and collected at the indicated times ...
Céline Hendricks (3307878) +5 more
core +1 more source
Image_5_STAT6 Upregulates NRP1 Expression in Endothelial Cells and Promotes Angiogenesis.tif
, 2022 The role of signal transducer and activator of transcription 6 (STAT6) in tumor growth has been widely recognized. However, its effects on the regulation of angiogenesis remain unclear.
Guanghui Ren (4229440) +3 more
core +1 more source
Cell Death and Disease, 2021 Neovascularization is a key factor that contributes to tumor metastasis, and vasculogenic mimicry (VM) is an important form of neovascularization found in highly invasive tumors, including lung cancer. Despite the increasing number of studies focusing on
Ran Fu +9 more
doaj +1 more source
Novel Small-Molecule Inhibitors of the SARS-CoV-2 Spike Protein Binding to Neuropilin 1
Pharmaceuticals, 2022 Furin cleavage of the SARS-CoV-2 spike protein results in a polybasic terminal sequence termed the C-end rule (CendR), which is responsible for the binding to neuropilin 1 (NRP1), enhancing viral infectivity and entry into the cell.
Anja Kolarič, Marko Jukič, Urban Bren
doaj +1 more source
Advanced Science, EarlyView.Liu et al. define a systems‐level interactome of fibroadipogenic progenitor (FAP)‐mediated signaling in skeletal muscle by integrating single‐cell transcriptomics with FAP depletion‐based perturbation analysis. Functional interrogation using a conditioned media bioassay links predicted signaling to multicellular outcomes, establishing a framework to ...
Xingyu Liu +13 more
wiley +1 more source
NRP1-Δ7 inhibits tumor growth and vascularization in vivo.
, 2016 (A) 2 x 106 PC3/TR/ NRP1-Δ7 cells were injected in each flank of nude mice (n = 8 mice). The animals were separated in two groups. The expression of the transgene was induced in one group by adding doxycycline (2 mg/ml) in drinking water.
Céline Hendricks (3307878) +5 more
core +1 more source