Results 201 to 210 of about 16,958 (303)

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Substorm expansion embedded in a global cycle of field-aligned currents and auroral electrojets. [PDF]

Nat Commun
Wang T, Dai L, Escoubet CP, Gonzalez W, Ren Y, Zhu M, Wang S, Wang C, Wang X, Wang K, Liu J.   +10 more
europepmc   +1 more source

Maritime Unmanned Vehicle Cruise Path Planning for Maritime Information Collection**The paper is supported by the Ministry of Science and Culture of Lower Saxony for funding us with the Graduate school Safe Automation of Maritime Systems (SAMS), the National Science Foundation of China (NSFC) through Grant No. 51579204, the self-determined and innovative research funds of WUT (No. 2016IVA064).

IFAC-PapersOnLine, 2016
Man Zhu, Axel Hahn, Yuan Q. Wen, Fan Zhang   +3 more
openaire   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

Proton-activated chloride channel PACC1 as acid sensor in epidermal desquamation. [PDF]

Proc Natl Acad Sci U S A
Xia K, Liu X, Wu J, Hu J, Cheng X, Mi T, Gao B, Mo X, Lu X, Cao F, Xie C, Cao J, Pernodet N, He G, Zhou H, Yao J.   +15 more
europepmc   +1 more source

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

Construction of Heteroleptic Copper Complexes in Perylene Diimide-Based COFs for Heterogeneous Metallaphotoredox Catalysis. [PDF]

J Am Chem Soc
Wu X, Guo J, Sun MY, Du T, Hao D, Liu D, Wang D, Wen S, Yin J, Li D, He J.   +10 more
europepmc   +1 more source

Overcoming the Trade‐Off Between Magnetic Coupling and Electrical Insulation in Soft Magnetic Materials via Nanochain Engineering

Advanced Science, EarlyView.
This study employs a nanochain engineering approach combined with an in situ oxidation strategy to fabricate self‐insulating iron‐based magnetic nanochains, addressing the challenge of balancing magnetic coupling and electrical insulation in soft magnetic materials.
Dingrong Zuo, Lichen Liu, Haibo Ke, Rongsheng Bai, Huaping Ding, Jing Zhou, Zhenxiang Cheng, Peng Yu, Weihua Wang   +8 more
wiley   +1 more source

Physical neural networks using sharpness-aware training. [PDF]

Nat Commun
Xu T, Luo Z, Liu S, Fan L, Xiao Q, Wang B, Wang D, Huang C.   +7 more
europepmc   +1 more source