Results 221 to 230 of about 34,086 (273)

Research Progress in Wearable Microneedle Sensors for Health Analysis

Advanced Sensor Research, EarlyView.
Wearable biosensors are transforming personal healthcare by enabling minimally invasive, molecular‐level monitoring. Emerging electrochemical microneedle sensors can detect analytes in interstitial fluid, enabling painless extraction and real‐time tracking.
Adnan Zameer, Yang Guo, Hongda Wang, Qiang Zhang   +3 more
wiley   +1 more source

De novo design of protein binders to stabilize monomeric TDP-43 and inhibit its pathological aggregation. [PDF]

Proc Natl Acad Sci U S A
Sun G, Li X, Hu J, Yang T, Liu C, Wang Z, Li D, Xu W.   +7 more
europepmc   +1 more source

Phase‐Separation of YAP Mediates AJUBA Super Enhancer Activation to Promote Aberrant Mitosis in Breast Cancer

Advanced Science, EarlyView.
YAP undergoes phase separation to activate the AJUBA super‐enhancer, driving aberrant mitosis through spindle checkpoint dysregulation in breast cancer. This study uncovers a mechanistic link between YAP condensates, super‐enhancer activation, and aneuploidy formation.
Rui Zhang, Qingwen Huang, Zhuo Chen, Weijian Meng, Hongliang Dong, Zhihong Qi, Liang Liu, Jie Shen, Daxing Xie   +8 more
wiley   +1 more source

Author Correction: Classification of distinct tendinopathy subtypes for precision therapeutics. [PDF]

Nat Commun
Tang C, Wang Z, Xie Y, Fei Y, Luo J, Wang C, Ying Y, He P, Yan R, Chen Y, Huang J, Xu Y, Wang Z, Heng BC, Liu H, Li J, Yin Z, Wu H, Chen W, Ouyang H, Chen X, Shen W.   +21 more
europepmc   +1 more source

CD207‐Positive Dendritic Cells Promote Emphysema Through CD8+ T Cell Pathway in Chronic Obstructive Pulmonary Disease

Advanced Science, EarlyView.
CD207+ dendritic cells (DCs) drive emphysema by promoting CD8⁺ T cell cytotoxicity via Birbeck granule‐dependent MHC‐I antigen presentation. This DC subset is expanded by cigarette smoke‐induced oxidative stress, which triggers granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) release from airway epithelium.
Shurui Xuan, Yunhui Wu, Feng Liu, Heng Fu, Yaqi Meng, Yingwei Ou, Xijing Yuan, Ian M. Adcock, Man Jia, Xiaoning Zeng, Xin Yao   +10 more
wiley   +1 more source

AI protocol for retrieving protein dynamic structures from two-dimensional infrared spectra. [PDF]

Proc Natl Acad Sci U S A
Ye S, Zhu L, Zhao Z, Wu F, Li Z, Wang B, Zhong K, Sun C, Mukamel S, Jiang J.   +9 more
europepmc   +1 more source

VDLIN: A Deep Learning‐Based Platform for Methylcobalamin‐Inspired Immunomodulatory Compound Screening

Advanced Science, EarlyView.
Using the convolutional neural network model VDLIN, Co7 is identified as a promising therapeutic candidate. Co7 demonstrates distinct advantages over MCB by effectively balancing anti‐inflammatory and immune‐stimulatory functions, making it a potential novel approach for immune modulation.
Xuefei Guo, Yang Zhao, Xianle Rong, Chenxi Niu, Shiyu Hu, Qiang Liu, Fuping You   +6 more
wiley   +1 more source

asxl1 C-terminal truncation and SRSF2 mutation drive leukemogenesis via immune reprogramming. [PDF]

Leukemia
Tu L, He F, Liew JM, Sin CF, Zheng L, Tsui SP, Miao X, Chan HY, Ma ACH, Zhang W, Zhang Y, Leung AYH, Sun X.   +12 more
europepmc   +1 more source

NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction

Advanced Science, EarlyView.
NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu, Jing Luo, Li Yu, Daoxi Qi, Boyu Li, Yating Chen, Chen Wang, Xiaokang Zhang, Wenzheng Guo, Qiyong Lou, Gang Zhai, Yonglin Ruan, Jianfei Huang, Shengchi Shi, Zhan Yin, Fang Zheng   +15 more
wiley   +1 more source

Detection of disk-jet coprecession in a tidal disruption event. [PDF]

Sci Adv
Wang Y, Lin Z, Wu L, Lei WH, Wei S, Zhang SN, Ji L, Del Palacio S, Baldi RD, Huang Y, Liu JF, Zhang B, Yang A, Chen RR, Zhang Y, Wang AL, Yang L, Charalampopoulos P, Williams-Baldwin DRA, Yao ZH, Xie FG, Bu D, Feng H, Cao X, Wu H, Li W, Qiao E, Leloudas G, Anderson JP, Shu X, Pasham DR, Zou H, Nicholl M, Wevers T, Müller-Bravo TE, Wang J, Wei JY, Qiu YL, Guo WJ, Gutiérrez CP, Gromadzki M, Inserra C, Makrygianni L, Onori F, Petrushevska T, Altamirano D, Galbany L, Peréz-Torres M, Chen TW.   +48 more
europepmc   +1 more source