Results 221 to 230 of about 34,006 (269)

TAPT1 interacts with SUCO to maintain the homeostasis of newly synthesized proteins and brain development in mice. [PDF]

Proc Natl Acad Sci U S A
Gao J, Yang F, Jiang Y, Zheng Y, Cai L, Huang X, Yuan L, Wang Y, Wang Y, Xu Z.   +9 more
europepmc   +1 more source

NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction

Advanced Science, EarlyView.
NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu, Jing Luo, Li Yu, Daoxi Qi, Boyu Li, Yating Chen, Chen Wang, Xiaokang Zhang, Wenzheng Guo, Qiyong Lou, Gang Zhai, Yonglin Ruan, Jianfei Huang, Shengchi Shi, Zhan Yin, Fang Zheng   +15 more
wiley   +1 more source

Vinyl Acetate-Enhanced Polyvinyl Chloride Gel with High Electroadhesion and Self-Heating-Tunability for Soft Robots in Freezing Environments. [PDF]

Adv Sci (Weinh)
Wei C, Zhang J, Liu L, Yan H, Wang K, He Y, Cui M, Zhu Z, Zhu J, Zhang W, Wang Z, Lu J.   +11 more
europepmc   +1 more source

Metformin Restores Mitochondrial Function and Neurogenesis in POLG Patient‐Derived Brain Organoids

Advanced Science, EarlyView.
Patient‐derived POLG‐mutant cortical organoids reveal neuronal subtype‐specific mitochondrial and synaptic defects, with dopaminergic neurons most affected. Metformin treatment restores neuronal identity, mitochondrial function, and excitability, increased mtDNA maintenance, and reprogrammed metabolism via TCA and redox pathways.
Zhuoyuan Zhang, Tsering Yangzom, Ning Lu, Shenglong Deng, Xianglu Xiao, Guang Yang, Kristina Xiao Liang   +6 more
wiley   +1 more source

Bow shock oscillations of Mars under weakly disturbed solar wind conditions. [PDF]

Nat Commun
Cheng L, Wang Y, Ma Y, Lillis R, Halekas J, Langlais B, Zhang T, Zhang A, Wang G, Xiao S, Zou Z, Chi Y, Hao X, Li Y, Pan Z, Liu K.   +15 more
europepmc   +1 more source

ROS Activated NETosis of Bone Marrow CD55+ Intermediate Mature Neutrophils Through HIF1α‐PADI4 Pathway to Initiate Bone Aging

Advanced Science, EarlyView.
In this study, we find CD55+ neutrophils show activated NETosis within bone marrow, induce BMSC senescence and osteogenesis inhibition, finally leading to bone aging initiation. Mechanistically, ROS synergizes with the CD55‐driven HIF1α‐PADI4 pathway to promote NETosis.
Yutong Guo, Shengjie Cui, Xi Wen, Yidi Wang, Ben Wu, Yixiang Wang, Yan Gu   +6 more
wiley   +1 more source

MRI cytometry imaging for cervical cancer differential diagnosis: a preliminary study. [PDF]

BMC Med Imaging
Yuan ZL, Shi DW, Guan H, Liu F, Wang ZS, Yang SY, Gao X, Feiweier T, Zhu JX, Jin ZY, Xu JZ, Li Y, Xue HD, He YL, Guo H.   +14 more
europepmc   +1 more source

IL1R2 Marks and Sorts a Spermatogonial Stem Cell Population Critical for Restoring Spermatogenesis Upon Interruption in Mammals

Advanced Science, EarlyView.
Spermatogonial stem cells (SSCs) provide critical support to spermatogenesis. Here, the author established Il1r2 as a sorting marker for SSCs, with which further insights into the SSC heterogeneity and dynamic features can be obtained. They also confirmed findings in both mouse and human, thus validating IL1R2 as the surface marker for isolating and ...
Pengyu Li, Zexuan Zhang, Zihan Xie, Cheng Jin, Zhipeng Wang, Changwei Yuan, Jun Zhu, Jielin Tang, Mengzhen Li, Dingfeng Zou, Xinyu Mang, Jun Liu, Dingyao Chen, Qi Geng, Yan Lu, Ning Zhang, Shiying Miao, Jing Peng, Kai Li, Wei Song   +19 more
wiley   +1 more source

Ultrahigh Dose Rate Irradiation Regulates Mitochondrial DNA-induced Interferon-β Secretion via Cytochrome c Leakage. [PDF]

MedComm (2020)
Lv J, Sun J, Luo Y, Liu J, Wu D, Fang Y, Mourou G, Huang S, Yang G, Yan X.   +9 more
europepmc   +1 more source

PHR‐Mediated Pi Starvation Response Mobile Messenger RNAs Represent Noncoding Transcripts in Recipient Tissues

Advanced Science, EarlyView.
Mobile messenger RNAs (mRNAs) can travel long distances, serving as systemic signals that participate in plant growth and stress acclimation. This work determines that PHR proteins mediate the Pi starvation response (PSR)‐specific long‐distance transport of mRNAs and that these PSR‐specific mobile mRNAs represent noncoding transcripts in recipient ...
Weiguo Dong, Shuman Wang, Chao Liu, Lulu Qiao, Kai Liu, Qiongli Jin, Xiaorong Mo, Xingxing Shen, Keke Yi, Zhiye Wang   +9 more
wiley   +1 more source