Results 81 to 90 of about 12,023 (208)

Genomics and Histopathology in Interstitial Cystitis/Bladder Pain Syndrome

Neurourology and Urodynamics, Volume 45, Issue 1, Page 54-59, January 2026.
ABSTRACT Aims In April of 2025, a Global Consensus meeting on IC/BPS was held in Winston‐Salem, NC. The goal of this meeting was to establish global consensus in diagnostic criteria, phenotyping, treatment outcome assessment, and possible etiopathology in interstitial cystitis/bladder pain syndrome (IC/BPS).
Hannah Ruetten, LaTasha K. Crawford, Elise J. B. De, Wencheng Li, Yoshiyuki Akiyama   +4 more
wiley   +1 more source

The Genomic and Proteomic Profiles of NTRK Genes and Trk Receptors in Liver Hepatocellular Carcinoma

Clinical Medicine Insights: Oncology, 2023
Background: The neurotrophic tyrosine kinase (NTRK) gene family includes NTRK1, NTRK2, and NTRK3, which encode tropomyosin receptor kinases TrkA, TrkB, and TrkC, respectively.
Hejing Wang, Lina Qi, Chenhan Zhong, Xuefeng Fang, Ying Yuan   +4 more
doaj   +1 more source

NTRK1 is a positive regulator of YAP oncogenic function [PDF]

Oncogene, 2018
Multiple cancer signalling networks take part in regulatory crosstalks with the Hippo tumour suppressor pathway through the transcriptional cofactor Yes-associated protein (YAP). Nevertheless, how YAP is controlled by pathway crosstalks in tumourigenesis remains poorly understood.
Xinyuan, Yang, He, Shen, Brian, Buckley, Yanmin, Chen, Nuo, Yang, Ashley L, Mussell, Mikhail, Chernov, Lester, Kobzik, Costa, Frangou, Su-Xia, Han, Jianmin, Zhang   +10 more
openaire   +2 more sources

Comparative Analysis of a Dual DNA–RNA Panel and a DNA‐Only Panel for Sarcoma: Real‐World Data From a Nationwide Genomic Database

Cancer Science, Volume 117, Issue 1, Page 156-168, January 2026.
Dual DNA–RNA panel with matched tumor–normal testing may improve diagnostic accuracy and inform treatment decisions in the routine clinical management of sarcoma. ABSTRACT Next‐generation sequencing‐based comprehensive cancer genomic profiling is promising in cancer management; however, most studies rely on tumor‐only DNA panels from single ...
Eiji Nakata, Kiichiro Ninomiya, Tatsunori Osone, Daisuke Ennishi, Shuta Tomida, Tomohiro Fujiwara, Toshiyuki Kunisada, Mashu Futagawa, Akira Hirasawa, Shinichi Toyooka, Toshifumi Ozaki   +10 more
wiley   +1 more source

Larotrectinib efficacy and safety in TRK fusion cancer: An expanded clinical dataset showing consistency in an age and tumor agnostic approach [PDF]

, 2018
Background: TRK fusion cancer results from gene fusions involving NTRK1, NTRK2 or NTRK3. Larotrectinib, the first selective TRK inhibitor, has demonstrated an overall response rate (ORR) of 75% with a favorable safety profile in the first 55 ...
Albert, C. M., Berlin, J. D., Bielack, S. S., Cox, M. C., Cruickshank, S., Doz, F., Drilon, A., Dubois, S. G., Federman, N., Geoerger, B., Hong, D. S., Ku, N. C., Kummar, S., Lassen, U. N., Mascarenhas, L., McDermott, R., Oh, D. Y., Schilder, R. J., Tan, D. S., van Tilburg, C. M.   +19 more
core   +1 more source

Influence of pharmacogenetic variability on the pharmacokinetics and toxicity of the aurora kinase inhibitor danusertib [PDF]

, 2010
Objectives Danusertib is a serine/threonine kinase inhibitor of multiple kinases, including aurora-A, B, and C. This explorative study aims to identify possible relationships between single nucleotide polymorphisms in genes coding for drug metabolizing ...
Anne-Joy de Graan, AS Zandvliet, Bernard Laffranchi, C Soncini, D Fancelli, D Fancelli, DR Camidge, Hans Gelderblom, Henk-Jan Guchelaar, J Zwaveling, J Zwaveling, JJ Swen, Judith A. M. Wessels, JW Mandema, JW Mandema, L Iyer, Maja J. A. de Jonge, Mariangela Mariani, MP Goetz, N Steeghs, N Steeghs, N Steeghs, N Steeghs, N Steeghs, N Steeghs, Neeltje Steeghs, P Carpinelli, P Carpinelli, P Carpinelli, P Carpinelli, P Carpinelli, P Carpinelli, P Therasse, RD Carvajal, Ron H. J. Mathijssen, S Purcell, SA Ridge, Silvia Comis, SL Warner, Tahar van der Straaten   +39 more
core   +5 more sources

Guiding Management of Bethesda V Thyroid Nodules: The Role of Molecular Testing

Clinical Endocrinology, Volume 104, Issue 1, Page 67-74, January 2026.
ABSTRACT Objective The 2023 Bethesda System update introduced molecular testing as a management option for Bethesda V cytology nodules, aiming to guide surgical decision‐making. This study investigates the correlation between molecular profiling and malignancy aggressiveness. Design We conducted a retrospective multicenter study involving patients with
Idit Tessler, Grégoire B. Morand, Nir A. Gecel, Arad Dotan, Tzahi Yamin, Eran E. Alon, Richard J. Payne, Galit Avior   +7 more
wiley   +1 more source

Piezo2 in Mechanosensory Biology: From Physiological Homeostasis to Disease‐Promoting Mechanisms

Cell Proliferation, Volume 59, Issue 1, January 2026.
Piezo2 channels are essential mechanotransducers regulating touch, proprioception and visceral mechanosensation across physiological systems, emerging as therapeutic targets for pathological mechanical hypersensitivity and neurogenic disorders. ABSTRACT Piezo2, a mechanically activated ion channel, serves as the key molecular transducer for touch ...
Zhebin Cheng, Zuping Wu, Mengjie Wu, Liang Xie, Qianming Chen   +4 more
wiley   +1 more source

MicroRNA Expression Profiling Altered by Variant Dosage of Radiation Exposure [PDF]

, 2014
[[abstract]]Various biological effects are associated with radiation exposure. Irradiated cells may elevate the risk for genetic instability, mutation, and cancer under low levels of radiation exposure, in addition to being able to extend the ...
Ingrid Y. Liu, Kuei-Fang Lee, Lawrence Shih-Hsin Wu, Paul Wei-Che Hsu, Yi-Cheng Chen   +4 more
core   +4 more sources

Malignancy Risk, Molecular Mutations, and Surgical Outcomes of Thyroid Nodules Classified as Atypia of Undetermined Significance in the Bethesda System: A Comprehensive Analysis

Cytopathology, Volume 37, Issue 1, Page 66-75, January 2026.
This study investigates the correlation between AUS subcategories, molecular mutations, and surgical outcomes in thyroid nodules classified as atypia of undetermined significance (AUS) under the Bethesda System for Reporting Thyroid Cytopathology.
Caroline Bourque, Gianluca Savoia, Maxine Noik, Livia Florianova, Saruchi Bandargal, Sabrina Daniela da Silva, Richard Payne, Marc Philippe Pusztaszeri   +7 more
wiley   +1 more source