Results 81 to 90 of about 149,980 (205)

Nuclear envelope transmembrane proteins in differentiation systems [PDF]

, 2012
Historically, our perception of the nuclear envelope has evolved from a simple barrier isolating the genome from the rest of a cell to a complex system that regulates functions including transcription, splicing, DNA replication and repair and ...
Batrakou, Dzmitry G.
core  

The nuclear envelope-a scaffold for silencing? [PDF]

, 2009
An increasing number of studies indicate that chromosomes are spatially organized in the interphase nucleus and that some genes tend to occupy characteristic zones of the nuclear volume. FISH studies in mammalian cells suggest a differential localization
Towbin, Benjamin D, Towbin, B D, Gasser, Susan M, Meister, Pierre, Meister, Peter, Gasser, Susan   +5 more
core   +1 more source

SUN proteins and nuclear envelope spacing [PDF]

, 2015
The nuclear envelope consists of 2membranes separated by 30–50 nm, but how the 2 membranes are evenly spaced has been an open question in the field. Nuclear envelope bridges composed of inner nuclear membrane SUN pro-teins and outer nuclear membrane KASH
Starr, Daniel A, Daniel A Starr, Natalie E Cain, Cain, Natalie E   +3 more
core   +1 more source

A multistage sequencing strategy pinpoints novel candidate alleles for Emery-Dreifuss muscular dystrophy and supports gene misregulation as its pathomechanism

EBioMedicine, 2020
Background: As genome-wide approaches prove difficult with genetically heterogeneous orphan diseases, we developed a new approach to identify candidate genes.
Peter Meinke, Alastair R.W. Kerr, Rafal Czapiewski, Jose I. de las Heras, Charles R. Dixon, Elizabeth Harris, Heike Kölbel, Francesco Muntoni, Ulrike Schara, Volker Straub, Benedikt Schoser, Manfred Wehnert, Eric C. Schirmer   +12 more
doaj   +1 more source

The increasing relevance of nuclear envelope myopathies [PDF]

, 2016
PURPOSE OF REVIEW: The nuclear envelope links to a wide range of disorders, including several myopathies and neuropathies over the past 2 decades; this has spurred research leading to a completely changed view of this important cellular structure and its
Meinke, Peter, Schirmer, Eric C., Peter Meinke, Eric C. Schirmer   +3 more
core   +1 more source

The ESCRT-III complex is required for nuclear pore complex sequestration and regulates gamete replicative lifespan in budding yeast meiosis

Nucleus, 2020
Cellular aging occurs as a cell loses its ability to maintain homeostasis. Aging cells eliminate damaged cellular compartments and other senescence factors via self-renewal.
Bailey A. Koch, Elizabeth Staley, Hui Jin, Hong-Guo Yu   +3 more
doaj   +1 more source

Functional characterization of LINC complex protein assemblies and their role in laminopathies [PDF]

, 2013
LINC (Linker of nucleoskeleton and cytoskeleton) complexes connect the nucleoskeleton to the cytoskeleton by interactions among LINC complex proteins and their interactions to proteins in the nucleus and the cytosol.
Yang, Liu
core  

Mitotic dynamics of the nuclear lamina behind the scenes of chromosome separation

Communications Biology
The regulation of mitosis is essential for genome inheritance and stability. In mammals, many cellular ultrastructures, including the nuclear envelope, undergo significant morphological changes to facilitate chromosome separation.
Julien Picotto, Pascale Bertrand, Gaëlle Pennarun   +2 more
doaj   +1 more source

Nuclear envelope organization in Dictyostelium discoideum [PDF]

, 2019
The nuclear envelope consists of the outer and the inner nuclear membrane, the nuclear lamina and the nuclear pore complexes, which regulate nuclear import and export.The major constituent of the nuclear lamina of Dictyostelium is the lamin NE81.
Meyer, Irene (Dr. rer. nat.), Batsios, Petros (Dr. rer. nat.), Batsios, Petros, Gräf, Ralph (Prof. Dr.), Koonce, Michael P., Larochelle, Denis A., Meyer, Irene, Gräf, Ralph   +7 more
core   +2 more sources

Exploring the evolution of the proteins of the plant nuclear envelope [PDF]

, 2016
International audienceIn this study, we explore the plasticity during evolution of proteins of the higher plant nuclear envelope (NE) from the most ancestral plant species to advanced angiosperms.
Probst, Aline V., Graumann, Katja, Evans, David, Probst, Aline, V., Tatout, Christophe, Poulet, Axel   +5 more
core   +1 more source