Results 81 to 90 of about 73,362 (284)

Human topoisomerase IIα nuclear export is mediated by two CRM-1-dependent nuclear export signals [PDF]

Journal of Cell Science, 2004
Resistance to chemotherapeutic drugs is a major obstacle in the treatment of leukemia and multiple myeloma. We have previously found that myeloma and leukemic cells in transition from low-density log phase conditions to high-density plateau phase conditions export substantial amounts of endogenous topoisomerase II alpha from the nucleus to the ...
Joel G, Turner, Roxanne, Engel, Jennifer A, Derderian, Richard, Jove, Daniel M, Sullivan   +4 more
openaire   +2 more sources

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

DNA binding domains in diverse nuclear receptors function as nuclear export signals [PDF]

, 2001
Background: The nuclear receptor superfamily of transcription factors directs gene expression through DNA sequence-specific interactions with target genes.
Rastinejad, Fraydoon, Holaska, J.M., Holaska, James M., Paschal, B.M., Bryce M. Paschal, Black, B.E., Black, Ben E., Ben E. Black, James M. Holaska, Paschal, Bryce M., Fraydoon Rastinejad   +10 more
core   +1 more source

Nuclear localization is required for Dishevelled function in Wnt/β-catenin signaling

Journal of Biology, 2005
Background Dishevelled (Dsh) is a key component of multiple signaling pathways that are initiated by Wnt secreted ligands and Frizzled receptors during embryonic development.
Sokol Sergei Y, Ratcliffe Marianne J, Bae Gyu-Un, Brott Barbara K, Itoh Keiji   +4 more
doaj   +1 more source

Nuclear Export and Retention Signals in the RS Domain of SR Proteins [PDF]

Molecular and Cellular Biology, 2002
Splicing factors of the SR protein family share a modular structure consisting of one or two RNA recognition motifs (RRMs) and a C-terminal RS domain rich in arginine and serine residues. The RS domain, which is extensively phosphorylated, promotes protein-protein interactions and directs subcellular localization and-in certain situations ...
Cazalla, Demian, Zhu, Jun, Manche, Lisa, Huber, Elisabeth, Krainer, Adrian R, Cáceres, Javier F   +5 more
openaire   +3 more sources

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Prediction of ligands to universally conserved binding sites of the influenza A virus nuclear export protein [PDF]

, 2019
The nuclear export protein (NEP) of the influenza A virus exports viral ribonucleoproteins to the host cell cytoplasm following nuclear transcription. In this work conservation analysis of 3000 protein sequences and molecular modelling of full-length NEP
Kukol, Andreas, Patel, H., Patel, Hershna, Kukol, A   +3 more
core   +1 more source

p35 regulates the CRM1-dependent nucleocytoplasmic shuttling of nuclear hormone receptor coregulator-interacting factor 1 (NIF-1).

PLoS ONE, 2014
Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase, which plays critical roles in a wide spectrum of neuronal functions including neuronal survival, neurite outgrowth, and synapse development and plasticity.
Xiao-Su Zhao, Wing-Yu Fu, Winnie W Y Chien, Zhen Li, Amy K Y Fu, Nancy Y Ip   +5 more
doaj   +1 more source

Nuclear-cytoplasmic trafficking of NTF2, the nuclear import receptor for the RanGTPase, is subjected to regulation. [PDF]

PLoS ONE, 2012
NTF2 is a cytosolic protein responsible for nuclear import of Ran, a small Ras-like GTPase involved in a number of critical cellular processes, including cell cycle regulation, chromatin organization during mitosis, reformation of the nuclear envelope ...
Shawn C Chafe, Jacqueline B Pierce, Dev Mangroo   +2 more
doaj   +1 more source