Results 1 to 10 of about 2,137,659 (362)

Ibetazol, a novel inhibitor of importin β1-mediated nuclear import [PDF]

Communications Biology
Nucleocytoplasmatic transport plays an essential role in eukaryotic cell homeostasis and is mediated by karyopherins. Importin β1 (KPNB1) and its adaptor protein importin α1 (KPNA2) are the best-characterized karyopherins that effect nuclear import. Here,
Thomas Vercruysse, Els Vanstreels, Maarten Jacquemyn, Sandro Boland, Amuri Kilonda, Sara Allasia, Ilse Vandecaetsbeek, Hugo Klaassen, Matthias Versele, Patrick Chaltin, Arnaud Marchand, Dirk Daelemans   +11 more
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Dynamics and regulation of nuclear import and nuclear movements of HIV-1 complexes. [PDF]

PLoS Pathogens, 2017
The dynamics and regulation of HIV-1 nuclear import and its intranuclear movements after import have not been studied. To elucidate these essential HIV-1 post-entry events, we labeled viral complexes with two fluorescently tagged virion-incorporated ...
Ryan C Burdick, Krista A Delviks-Frankenberry, Jianbo Chen, Sanath K Janaka, Jaya Sastri, Wei-Shau Hu, Vinay K Pathak   +6 more
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Phospholipid scramblase 1 interacts with influenza A virus NP, impairing its nuclear import and thereby suppressing virus replication. [PDF]

PLoS Pathogens, 2018
Transcription and replication of the influenza A virus (IAV) genome occur in the nucleus of infected cells and are carried out by the viral ribonucleoprotein complex (vRNP).
Weiyu Luo, Jie Zhang, Libin Liang, Guangwen Wang, Qibing Li, Pengyang Zhu, Yuan Zhou, Junping Li, Yuhui Zhao, Nan Sun, Shanyu Huang, Chenchen Zhou, Yu Chang, Pengfei Cui, Pucheng Chen, Yongping Jiang, Guohua Deng, Zhigao Bu, Chengjun Li, Li Jiang, Hualan Chen   +20 more
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Influenza A viruses escape from MxA restriction at the expense of efficient nuclear vRNP import [PDF]

Scientific Reports, 2016
To establish a new lineage in the human population, avian influenza A viruses (AIV) must overcome the intracellular restriction factor MxA. Partial escape from MxA restriction can be achieved when the viral nucleoprotein (NP) acquires the critical human ...
Veronika Götz, Linda Magar, Dominik Dornfeld, Sebastian Giese, Anne Pohlmann, Dirk W. Höper, Byung‐Whi Kong, David A. Jans, Martin Beer, Otto Haller, Martin Schwemmle   +10 more
openalex   +2 more sources

Direct visualization of HIV-1 core nuclear import and its interplay with the nuclear pore [PDF]

EMBO Reports
Direct visualization of HIV-1 nuclear import through the nuclear pore complex (NPC) presents a technical challenge due to the rarity of this process.
Zhen Hou, Stanley Fronik, Yao Shen, Long Chen, Christopher Thompson, Sarah Neumann, Peijun Zhang   +6 more
doaj   +2 more sources

Mechanical control of nuclear import by Importin-7 is regulated by its dominant cargo YAP

Nature Communications, 2022
The translation of mechanical cues into gene expression changes is dependent on the nuclear import of mechanoresponsive transcriptional regulators. Here the authors identify that Importin-7 drives the nuclear import of one such regulator YAP while YAP ...
María García-García, Sara Sánchez-Perales, Patricia Jarabo, Enrique Calvo, Trevor Huyton, Liran Fu, Sheung Chun Ng, Laura Sotodosos-Alonso, Jesús Vázquez, Sergio Casas-Tintó, Dirk Görlich, Asier Echarri, Miguel A. Del Pozo   +12 more
doaj   +2 more sources

Dissecting the Nuclear Import of the Ribosomal Protein Rps2 (uS5) [PDF]

Biomolecules, 2023
The ribosome is assembled in a complex process mainly taking place in the nucleus. Consequently, newly synthesized ribosomal proteins have to travel from the cytoplasm into the nucleus, where they are incorporated into nascent ribosomal subunits. In this
Andreas Steiner, Sébastien Favre, Maximilian Mack, Annika Hausharter, Benjamin Pillet, Jutta Hafner, Valentin Mitterer, Dieter Kressler, Brigitte Pertschy, Ingrid Zierler   +9 more
doaj   +2 more sources

Mediated nuclear import and export of TAZ and the underlying molecular requirements [PDF]

Nature Communications, 2018
Nucleocytoplasmic distribution of Yap/TAZ is regulated by the Hippo pathway and the cytoskeleton. While interactions with cytosolic and nuclear “retention factors” (14–3–3 and TEAD) are known to control their localization, fundamental aspects of Yap/TAZ ...
Michael Kofler, Pam Speight, Darby Little, Caterina Di Ciano‐Oliveira, Katalin Szászi, András Kapùs   +5 more
openalex   +2 more sources

HIV-1 Uncoating and Nuclear Import Precede the Completion of Reverse Transcription in Cell Lines and in Primary Macrophages

Viruses, 2020
An assembly of capsid proteins (CA) form the mature viral core enclosing the HIV-1 ribonucleoprotein complex. Discrepant findings have been reported regarding the cellular sites and the extent of core disassembly (uncoating) in infected cells.
Ashwanth C. Francis, Mariana Marin, Mathew J. Prellberg, Kristina Palermino-Rowland, Gregory B. Melikyan   +4 more
doaj   +2 more sources

HIV-1 exploits importin 7 to maximize nuclear import of its DNA genome [PDF]

Retrovirology, 2009
Background Nuclear import of the HIV-1 reverse transcription complex (RTC) is critical for infection of non dividing cells, and importin 7 (imp7) has been implicated in this process.
Leyens Lada, Cherepanov Peter, Zaitseva Lyubov, Wilson Sam J, Rasaiyaah Jane, Fassati Ariberto   +5 more
doaj   +5 more sources