Viruses, 2021 The delivery of the HIV-1 genome into the nucleus is an indispensable step in retroviral infection of non-dividing cells, but the mechanism of HIV-1 nuclear import has been a longstanding debate due to controversial experimental evidence. It was commonly
Qi Shen +4 more
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Nuclear Import of Yeast Proteasomes [PDF]
Cells, 2015 Proteasomes are highly conserved protease complexes responsible for the degradation of aberrant and short-lived proteins. In highly proliferating yeast and mammalian cells, proteasomes are predominantly nuclear.
Julianne Burcoglu +2 more
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KRT6A Restricts Influenza A Virus Replication by Inhibiting the Nuclear Import and Assembly of Viral Ribonucleoprotein Complex [PDF]
VirusesThe transcription and replication of the genome of influenza A virus (IAV) take place in the nucleus of infected cells, which is catalyzed by the viral ribonucleoprotein (vRNP) complex. The nuclear import of the vRNP complex and its component proteins is
Yu Chang +9 more
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Viral Targeting of Importin Alpha-Mediated Nuclear Import to Block Innate Immunity [PDF]
Cells, 2023 Cellular nucleocytoplasmic trafficking is mediated by the importin family of nuclear transport proteins. The well-characterized importin alpha (IMPA) and importin beta (IMPB) nuclear import pathway plays a crucial role in the innate immune response to ...
Olivia A. Vogel +4 more
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Nonclassical nuclear localization signals mediate nuclear import of CIRBP [PDF]
Proceedings of the National Academy of Sciences, 2020 Significance We uncovered a molecular mechanism by which multiple importins regulate nuclear import, phase separation, and stress granule recruitment of an RNA-binding protein.
Benjamin Bourgeois +11 more
semanticscholar +4 more sources
The nuclear localization signal of CPSF6 governs post-nuclear import steps of HIV-1 infection. [PDF]
PLoS PathogensThe early stages of HIV-1 infection include the trafficking of the viral core into the nucleus of infected cells. However, much remains to be understood about how HIV-1 accomplishes nuclear import and the consequences of the import pathways utilized on ...
Nicholas Rohlfes +6 more
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Nuclear Import Defects Drive Cell Cycle Dysregulation in Neurodegeneration. [PDF]
Aging CellPlessis-Belair J +3 more
europepmc +3 more sources
A new class of capsid-targeting inhibitors that specifically block HIV-1 nuclear import [PDF]
EMBO Molecular MedicineHIV-1 capsids cross nuclear pore complexes (NPCs) by engaging with the nuclear import machinery. To identify compounds that inhibit HIV-1 nuclear import, we screened drugs in silico on a three-dimensional model of a CA hexamer bound by Transportin-1 (TRN-
Aude Boulay +13 more
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Baculovirus Nuclear Import: Open, Nuclear Pore Complex (NPC) Sesame [PDF]
Viruses, 2013 Baculoviruses are one of the largest viruses that replicate in the nucleus of their host cells. During infection, the rod-shape, 250-nm long nucleocapsid delivers its genome into the nucleus.
Wei Wu, Shelly Au, Nelly Panté
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Yeast 26S proteasome nuclear import is coupled to nucleus-specific degradation of the karyopherin adaptor protein Sts1 [PDF]
Scientific ReportsIn eukaryotes, the ubiquitin–proteasome system is an essential pathway for protein degradation and cellular homeostasis. 26S proteasomes concentrate in the nucleus of budding yeast Saccharomyces cerevisiae due to the essential import adaptor protein Sts1
Carolyn Allain Breckel +3 more
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