Results 21 to 30 of about 2,137,659 (362)

Sphingosine simultaneously inhibits nuclear import and activates PP2A by binding importins and PPP2R1A. [PDF]

EMBO J
Jayashankar V, Kubiniok P, McCracken AN, Gentry RG, Eckenstein KH, Sernissi L, Vece V, Garsi JB, Valles SY, Jung S, Hoffman NC, Perrochon AS, Selwan EM, Finicle BT, Pitman M, Lin D, Bonneil É, Xu R, Mao C, Kaiser P, Fruman DA, Mobley D, Jang C, Hanessian S, Thibault P, Edinger AL.   +25 more
europepmc   +2 more sources

Nuclear import of histones [PDF]

Biochemical Society Transactions, 2020
The transport of histones from the cytoplasm to the nucleus of the cell, through the nuclear membrane, is a cellular process that regulates the supply of new histones in the nucleus and is key for DNA replication and transcription. Nuclear import of histones is mediated by proteins of the karyopherin family of nuclear transport receptors.
Natalia Elisa Bernardes, Yuh Min Chook
openaire   +2 more sources

Non-transport roles of nuclear import receptors: In need of the right balance

Frontiers in Cell and Developmental Biology, 2022
Nuclear import receptors ensure the recognition and transport of proteins across the nuclear envelope into the nucleus. In addition, as diverse processes as mitosis, post-translational modifications at mitotic exit, ciliogenesis, and phase separation ...
Michela Damizia, Ludovica Altieri, Ludovica Altieri, Patrizia Lavia, Patrizia Lavia   +4 more
doaj   +1 more source

Release of Severe Acute Respiratory Syndrome Coronavirus Nuclear Import Block Enhances Host Transcription in Human Lung Cells

Journal of Virology, 2013
Amy Sims, Susan C. Tilton, Vineet D. Menachery, Lisa E. Gralinski, Alexandra Schäfer, Melissa M. Matzke, Bobbie‐Jo Webb‐Robertson, Jean Chang, Maria L. Luna, Casey Long, Anil Shukla, Armand Bankhead, Susan E. Burkett, Gregory A. Zornetzer, Chien‐Te K. Tseng, Thomas Metz, Raymond J. Pickles, Shannon K. McWeeney, Richard Smith, Michael G. Katze, Katrina M. Waters, Ralph S. Baric   +21 more
openalex   +3 more sources

Effect of VIRP1 Protein on Nuclear Import of Citrus Exocortis Viroid (CEVd)

Biomolecules, 2021
Before replicating, Pospiviroidae viroids must move into the plant nucleus. However, the mechanisms of viroid nuclear import are not entirely understood.
Hyesu Seo, Kyunghee Kim, Woong June Park
doaj   +1 more source

Increased nuclear import characterizes aberrant nucleocytoplasmic transport in neurons from patients with spinocerebellar ataxia type 7. [PDF]

Front Mol Neurosci
Macopson-Jones JG, Adams M, Philippe J, La Spada AR.   +3 more
europepmc   +3 more sources

Types of nuclear localization signals and mechanisms of protein import into the nucleus

Cell communication and signaling : CCS, 2021
Nuclear localization signals (NLS) are generally short peptides that act as a signal fragment that mediates the transport of proteins from the cytoplasm into the nucleus.
Juane Lu, Tao Wu, Biao Zhang, Suke Liu, Wenjun Song, Jianjun Qiao, Haihua Ruan   +6 more
semanticscholar   +1 more source

SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance To successfully establish infection, viral pathogens have to overcome the interferon (IFN)-mediated antiviral response. Previous studies revealed that the viral accessory protein Orf6 of SARS-CoV and SARS-CoV-2 is able to inhibit STAT1 ...
Lisa Miorin, Thomas Kehrer, M. T. Sánchez-Aparicio, Ke Zhang, Phillip Cohen, Roosheel S. Patel, Anastasija Cupic, T. Makio, Menghan Mei, Elena Moreno, Oded Danziger, K. White, R. Rathnasinghe, Melissa B. Uccellini, Shengyan Gao, T. Aydillo, I. Mena, Xin Yin, Laura Martin-Sancho, N. Krogan, S. Chanda, M. Schotsaert, R. Wozniak, Yi Ren, Brad R. Rosenberg, B. Fontoura, A. García-Sastre   +26 more
semanticscholar   +1 more source

MxB impedes the NUP358-mediated HIV-1 pre-integration complex nuclear import and viral replication cooperatively with CPSF6

Retrovirology, 2020
Background The human myxovirus resistance 2 (Mx2/MxB) protein was originally found to regulate cytoplasmic-nuclear transport but was recently reported to restrict HIV-1 replication by binding to HIV-1 capsid (CA), preventing uncoating, the nuclear import
Linlin Xie, Lang Chen, Chaojie Zhong, Ting Yu, Zhao Ju, Meirong Wang, Hairong Xiong, Yan Zeng, Jianhua Wang, Haitao Hu, Wei Hou, Yong Feng   +11 more
doaj   +1 more source

CRISPR/Cas9-Induced Mutagenesis Corroborates the Role of Transportin-SR2 in HIV-1 Nuclear Import

Microbiology Spectrum, 2021
To infect nondividing cells, HIV-1 needs to cross the nuclear membrane. The importin transportin-SR2 (TRN-SR2 or transportin-3) has been proposed to mediate HIV-1 nuclear import, but the detailed mechanism remains unresolved.
Julie Janssens, Jolien Blokken, Yulia Lampi, Flore De Wit, Irena Zurnic Bonisch, Ivan Nombela, Paulien Van de Velde, Barbara Van Remoortel, Rik Gijsbers, Frauke Christ, Zeger Debyser   +10 more
doaj   +1 more source