Results 1 to 10 of about 163,417 (257)

Roles of the Nuclear Lamina in Stable Nuclear Association and Assembly of a Herpesviral Transactivator Complex on Viral Immediate-Early Genes [PDF]

mBio, 2012
Little is known about the mechanisms of gene targeting within the nucleus and its effect on gene expression, but most studies have concluded that genes located near the nuclear periphery are silenced by heterochromatin.
Ace, Bolzer, Boyle, Brown, Cai, Cliffe, Cliffe, Croft, de Bruyn Kops, Deniaud, Everett, Finlan, Gerster, Gilchrist, Guelen, Herrera, Hewitt, Huang, Imai, Kent, Knipe, Kolb, Kosak, Kosak, Kristie, Kristie, Kristie, Kristie, Kumaran, Kutluay, Kutluay, Kwiatkowski, Levsky, Liang, Mahajan, Malhas, Mayer, McKnight, Meister, Narayanan, Neely, Ottosen, O’Hare, Pickersgill, Preston, Quinlan, Reddy, Roizman, Shimi, Showalter, Silva, Simpson-Holley, Sullivan, Taylor, Utley, Wang, Weierich, Williams, Wilson, Wysocka, Xiao, Yusufzai   +61 more
core   +5 more sources

Reorganization of the nuclear lamina and cytoskeleton in adipogenesis [PDF]

, 2011
A thorough understanding of fat cell biology is necessary to counter the epidemic of obesity. Although molecular pathways governing adipogenesis are well delineated, the structure of the nuclear lamina and nuclear-cytoskeleton junction in this process ...
C Capanni, E Markiewicz, ED Rosen, F Bouwman, Fons Verheyen, Frans C. S. Ramaekers, Helma J. Kuijpers, J Lammerding, J Renes, JL Broers, Johan Renes, Jos L. V. Broers, K Tilgner, K Wilhelmsen, KN Dahl, M Carmo-Fonseca, M Crisp, M Wabitsch, Martin Wabitsch, Maurice A. M. Steensel, Miriam Kamps, P Fischer-Posovszky, P Scaffidi, Peter M. Steijlen, R Akter, RG Parton, RL Boguslavsky, TH Hoger, Valerie L. R. M. Verstraeten, VL Verstraeten, VL Verstraeten, VL Verstraeten, WW Franke, Y Hieda   +33 more
core   +9 more sources

Chromatin epigenetics and nuclear lamina keep the nucleus in shape: Examples from natural and accelerated aging [PDF]

, 2022
As the repository of genetic information, the cell nucleus must protect DNA integrity from mechanical stresses. The nuclear lamina, which resides within the nuclear envelope (NE), is made up of lamins, intermediate filaments bound to DNA.
Barra, Viviana, Carollo, Pietro Salvatore   +1 more
core   +3 more sources

Constitutive nuclear lamina-genome interactions are highly conserved and associated with A/T-rich sequence [PDF]

, 2012
In metazoans, the nuclear lamina is thought to play an important role in the spatial organization of interphase chromosomes, by providing anchoring sites for large genomic segments named lamina-associated domains (LADs).
Beaudry, Jean-Bernard, Kellis, Manolis, Kind, Jop, Meuleman, Wouter, Pagie, Ludo, Peric-Hupkes, Daan, Reinders, Marcel, van Steensel, Bas, Wessels, Lodewyk   +8 more
core   +3 more sources

Co-dependence between trypanosome nuclear lamina components in nuclear stability and control of gene expression [PDF]

, 2016
The nuclear lamina is a filamentous structure subtending the nuclear envelope and required for chromatin organization, transcriptional regulation and maintaining nuclear structure.
Alexander V. Ratushny, Brian T. Chait, David Horn, Hoek, Houben, Jean-Mathieu Bart, John D. Aitchison, Luke Maishman, Marchetti, Mark C. Field, Michael P. Rout, Miguel Navarro, Sam Alsford, Samson O. Obado, Wei-Ming Chen   +14 more
core   +3 more sources

Evolutionary, structural and functional insights in nuclear organisation and nucleocytoplasmic transport in trypanosomes [PDF]

, 2023
One of the remarkable features of eukaryotes is the nucleus, delimited by the nuclear envelope (NE), a complex structure and home to the nuclear lamina and nuclear pore complex (NPC). For decades, these structures were believed to be mainly architectural
Field, Mark C., Padilla-Mejia, Norma E.
core   +1 more source

A hub and spoke nuclear lamina architecture in trypanosomes [PDF]

, 2021
The nuclear lamina supports many functions, including maintaining nuclear structure and gene expression control, and correct spatio-temporal assembly is vital to meet these activities.
Aaronson, Ahn, Alibu, Allan, Alsford, Aslett, Benz, Bessat, Burkard, Chatel, Constantinescu, Cox, D'Archivio, Dean, Dean, Dechat, Dechat, DeGrasse, Depreux, Dobin, DuBois, Erben, Ersfeld, Faria, Field, Field, Figueiredo, Florini, Gadelha, Gesson, Glover, Gluenz, Goldberg, Goldberg, Goos, Gruenbaum, Hirumi, Holden, Hübner, Ibarra, Izumi, Kang, Kelly, Kim, Koreny, Lehner, Liu, Lueong, Lupas, Maishman, Makarov, Mounkes, Muchir, Muchir, Mugnier, Mugo, Müller, Naetar, Ngô, Nmezi, Obado, Oberholzer, Ogbadoyi, Pinger, Radwanska, Redmond, Rober, Roditi, Saura, Schumann Burkard, Shimi, Shimi, Siddam, Simon, Stijlemans, Strawn, Stuurman, Swift, Sylvius, Turgay, Tyanova, Verstraeten, Vidak, Vizcaíno, Wirtz, Woodward, Wu, Yang, Yatskevich, Zahr, Zheng   +90 more
core   +1 more source

A genetic locus targeted to the nuclear periphery in living cells maintains its transcriptional competence [PDF]

, 2008
The peripheral nuclear lamina, which is largely but not entirely associated with inactive chromatin, is considered to be an important determinant of nuclear structure and gene expression.
Kumaran, R. I., Spector, D. L.
core   +2 more sources

Actin assembly ruptures the nuclear envelope by prying the lamina away from nuclear pores and nuclear membranes in starfish oocytes.

, 2020
The nucleus of oocytes (germinal vesicle) is unusually large and its nuclear envelope (NE) is densely packed with nuclear pore complexes (NPCs) stockpiled for embryonic development. We showed that breakdown of this specialized NE is mediated by an Arp2/3-
Avilov, I., Geiss, C., Kondo, H., Lenart, P., Machado, P., Mori, M., Wesolowska, N.   +6 more
core   +1 more source

Cyclin D1 integrates G9a-mediated histone methylation. [PDF]

, 2019
Lysine methylation of histones and non-histone substrates by the SET domain containing protein lysine methyltransferase (KMT) G9a/EHMT2 governs transcription contributing to apoptosis, aberrant cell growth, and pluripotency.
Casimiro, Mathew C., Chepelev, Iouri, Dampier, William, Di Sante, Gabriele, Ertel, Adam, Jeltsch, Albert, Jiao, Xuanmao, Ju, Xiaoming, Katiyar, Sanjay, Klopfenstein, D. V., Li, Zhiping, Pestell, Richard G., Tozeren, Aydin, Wang, Min   +13 more
core   +2 more sources