Extreme wrinkling of the nuclear lamina is a morphological marker of cancer [PDF]
npj Precision OncologyNuclear atypia is a hallmark of cancer. A recent model posits that excess surface area, visible as folds/wrinkles in the lamina of a rounded nucleus, allows the nucleus to take on diverse shapes with little mechanical resistance.
Ting-Ching Wang +10 more
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PRR14 organizes H3K9me3-modified heterochromatin at the nuclear lamina [PDF]
Nucleus, 2023 The eukaryotic genome is organized in three dimensions within the nucleus. Transcriptionally active chromatin is spatially separated from silent heterochromatin, a large fraction of which is located at the nuclear periphery.
Anna A. Kiseleva +4 more
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Automated Nuclear Lamina Network Recognition and Quantitative Analysis in Structured Illumination Super-Resolution Microscope Images Using a Gaussian Mixture Model and Morphological Processing [PDF]
Photonics, 2020 Studying the architecture of nuclear lamina networks is significantly important in biomedicine owing not only to their influence on the genome, but also because they are associated with several diseases.
Yiwei Chen +8 more
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Biology and Model Predictions of the Dynamics and Heterogeneity of Chromatin-Nuclear Lamina Interactions [PDF]
Frontiers in Cell and Developmental Biology, 2022 Associations of chromatin with the nuclear lamina, at the nuclear periphery, help shape the genome in 3 dimensions. The genomic landscape of lamina-associated domains (LADs) is well characterized, but much remains unknown on the physical and mechanistic ...
Julia Madsen-Østerbye +5 more
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Nuclear shapes are geometrically determined by the excess surface area of the nuclear lamina [PDF]
Frontiers in Cell and Developmental Biology, 2023 Introduction: Nuclei have characteristic shapes dependent on cell type, which are critical for proper cell function, and nuclei lose their distinct shapes in multiple diseases including cancer, laminopathies, and progeria.
Richard B. Dickinson +3 more
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Baculovirus infection induces disruption of the nuclear lamina [PDF]
Scientific Reports, 2017 Baculovirus nucleocapsids egress from the nucleus primarily via budding at the nuclear membrane. The nuclear lamina underlying the nuclear membrane represents a substantial barrier to nuclear egress. Whether the nuclear lamina undergoes disruption during
Xiaomei Zhang +5 more
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The nuclear lamina binds the EBV genome during latency and regulates viral gene expression [PDF]
PLoS Pathogens, 2022 The Epstein Barr virus (EBV) infects almost 95% of the population worldwide. While typically asymptomatic, EBV latent infection is associated with several malignancies of epithelial and lymphoid origin in immunocompromised individuals.
Lisa Beatrice Caruso +9 more
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Remodeling of the Nuclear Envelope and Lamina during Bovine Preimplantation Development and Its Functional Implications. [PDF]
PLoS ONE, 2015 The present study demonstrates a major remodeling of the nuclear envelope and its underlying lamina during bovine preimplantation development. Up to the onset of major embryonic genome activation (MGA) at the 8-cell stage nuclei showed a non-uniform ...
Jens Popken +9 more
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3D Single Molecule Super-Resolution Microscopy of Whole Nuclear Lamina [PDF]
Frontiers in Chemistry, 2022 Single molecule (SM) super-resolution microscopies bypass the diffraction limit of conventional optical techniques and provide excellent spatial resolutions in the tens of nanometers without overly complex microscope hardware.
Ashley M. Rozario +7 more
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Co-dependence between trypanosome nuclear lamina components in nuclear stability and control of gene expression [PDF]
, 2016 The nuclear lamina is a filamentous structure subtending the nuclear envelope and required for chromatin organization, transcriptional regulation and maintaining nuclear structure.
Luke Maishman +11 more
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