PRR14 organizes H3K9me3-modified heterochromatin at the nuclear lamina [PDF]
Nucleus, 2023 The eukaryotic genome is organized in three dimensions within the nucleus. Transcriptionally active chromatin is spatially separated from silent heterochromatin, a large fraction of which is located at the nuclear periphery.
Anna A. Kiseleva +4 more
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The Nuclear Lamina: Protein Accumulation and Disease [PDF]
Biomedicines, 2020 Cellular health is reliant on proteostasis—the maintenance of protein levels regulated through multiple pathways modulating protein synthesis, degradation and clearance. Loss of proteostasis results in serious disease and is associated with aging.
Carla Almendáriz-Palacios +7 more
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Cold Spring Harb Perspect Biol, 2022 Lamins interact with a host of nuclear membrane proteins, transcription factors, chromatin regulators, signaling molecules, splicing factors, and even chromatin itself to form a nuclear subcompartment, the nuclear lamina, that is involved in a variety of
Wong X, Melendez-Perez AJ, Reddy KL.
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Interactions of Chromatin with the Nuclear Lamina and Nuclear Pore Complexes. [PDF]
Int J Mol Sci, 2023 Heterochromatin and euchromatin form different spatial compartments in the interphase nucleus, with heterochromatin being localized mainly at the nuclear periphery.
Shevelyov YY.
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Nuclear lamina strain states revealed by intermolecular force biosensor. [PDF]
Nat Commun, 2023 Nuclear lamins have been considered to be an important structural element of the nucleus. The nuclear lamina is thought both to shield DNA from excessive mechanical forces and to transmit mechanical forces onto the DNA.
Danielsson BE +8 more
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The Prolyl Isomerase Pin1 Promotes the Herpesvirus-Induced Phosphorylation-Dependent Disassembly of the Nuclear Lamina Required for Nucleocytoplasmic Egress. [PDF]
PLoS Pathogens, 2016 The nuclear lamina lines the inner nuclear membrane providing a structural framework for the nucleus. Cellular processes, such as nuclear envelope breakdown during mitosis or nuclear export of large ribonucleoprotein complexes, are functionally linked to
Jens Milbradt +10 more
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The plant nuclear lamina disassembles to regulate genome folding in stress conditions. [PDF]
Nat Plants, 2023 The nuclear lamina (NL) is a complex network of nuclear lamins and lamin-associated nuclear membrane proteins, which scaffold the nucleus to maintain structural integrity. In Arabidopsis thaliana, Nuclear Matrix Constituent Proteins (NMCPs) are essential
Wang N +11 more
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The nuclear lamina couples mechanical forces to cell fate in the preimplantation embryo via actin organization. [PDF]
Nat Commun, 2023 During preimplantation development, contractile forces generated at the apical cortex segregate cells into inner and outer positions of the embryo, establishing the inner cell mass (ICM) and trophectoderm.
Skory RM +11 more
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Mena regulates nesprin-2 to control actin-nuclear lamina associations, trans-nuclear membrane signalling and gene expression. [PDF]
Nat Commun, 2023 Interactions between cells and the extracellular matrix, mediated by integrin adhesion complexes, play key roles in fundamental cellular processes, including the sensing and transduction of mechanical cues.
Li Mow Chee F +16 more
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Biology and Model Predictions of the Dynamics and Heterogeneity of Chromatin-Nuclear Lamina Interactions [PDF]
Frontiers in Cell and Developmental Biology, 2022 Associations of chromatin with the nuclear lamina, at the nuclear periphery, help shape the genome in 3 dimensions. The genomic landscape of lamina-associated domains (LADs) is well characterized, but much remains unknown on the physical and mechanistic ...
Julia Madsen-Østerbye +5 more
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