Structural and Mechanical Aberrations of the Nuclear Lamina in Disease [PDF]
Cells, 2020 The nuclear lamins are the major components of the nuclear lamina in the nuclear envelope. Lamins are involved in numerous functions, including a role in providing structural support to the cell and the mechanosensing of the cell.
Merel Stiekema +3 more
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Role of the Nuclear Lamina in Age-Associated Nuclear Reorganization and Inflammation [PDF]
Cells, 2020 Aging is characterized by the gradual loss of tissue function and integrity. Activation of inflammatory responses accelerates the deterioration of cells and tissues.
Lidya Kristiani, Miri Kim, Youngjo Kim
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Mapping the micro-proteome of the nuclear lamina and lamina-associated domains. [PDF]
Life Sci Alliance, 2021 The nuclear lamina provides structure to the nucleus and serves as an interface between the cytoskeleton and large heterochromatin domains called LADs. This study describes the microproteome of this LAD/lamina interface.
Wong X +6 more
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Autophagy mediates degradation of nuclear lamina [PDF]
Nature, 2015 Macroautophagy (hereafter referred to as autophagy) is a catabolic membrane trafficking process that degrades a variety of cellular constituents and is associated with human diseases.
Zhixun Dou +19 more
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Nuclear shapes are geometrically determined by the excess surface area of the nuclear lamina [PDF]
Frontiers in Cell and Developmental Biology, 2023 Introduction: Nuclei have characteristic shapes dependent on cell type, which are critical for proper cell function, and nuclei lose their distinct shapes in multiple diseases including cancer, laminopathies, and progeria.
Richard B. Dickinson +3 more
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Chromatin epigenetics and nuclear lamina keep the nucleus in shape: Examples from natural and accelerated aging [PDF]
Biology of the Cell, 2022 As the repository of genetic information, the cell nucleus must protect DNA integrity from mechanical stresses. The nuclear lamina, which resides within the nuclear envelope (NE), is made up of lamins, intermediate filaments bound to DNA.
Pietro Salvatore Carollo, Viviana Barra
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The intriguing plant nuclear lamina [PDF]
Frontiers in Plant Science, 2014 The nuclear lamina is a complex protein mesh attached to the inner nuclear membrane, which is also associated with nuclear pore complexes. It provides mechanical support to the nucleus and nuclear envelope, and as well as facilitating the connection of ...
Malgorzata eCiska +1 more
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Tyrosine phosphorylation of lamin A by Src promotes disassembly of nuclear lamina in interphase. [PDF]
Life Sci Alliance, 2021 Phosphorylation of lamin A at tyrosine residue 45 by Src has an adverse effect on the assembly of nuclear lamina, which may be involved in nuclear dysmorphia, genomic instability, and nuclear plasticity in interphase.
Chu CT, Chen YH, Chiu WT, Chen HC.
europepmc +2 more sources
Nuclear Envelope, Nuclear Lamina, and Inherited Disease [PDF]
, 2005 The nuclear envelope is composed of the nuclear membranes, nuclear lamina, and nuclear pore complexes. In recent years, mutations in nuclear-envelope proteins have been shown to cause a surprisingly wide array of inherited diseases. While the mutant proteins are generally expressed in most or all differentiated somatic cells, many mutations cause ...
Worman, Howard, Courvalin, Jean-Claude
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Extreme wrinkling of the nuclear lamina is a morphological marker of cancer [PDF]
npj Precision OncologyNuclear atypia is a hallmark of cancer. A recent model posits that excess surface area, visible as folds/wrinkles in the lamina of a rounded nucleus, allows the nucleus to take on diverse shapes with little mechanical resistance.
Ting-Ching Wang +10 more
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