Remodeling of the Nuclear Envelope and Lamina during Bovine Preimplantation Development and Its Functional Implications [PDF]
PLoS ONE, 2015 The present study demonstrates a major remodeling of the nuclear envelope and its underlying lamina during bovine preimplantation development. Up to the onset of major embryonic genome activation (MGA) at the 8-cell stage nuclei showed a non-uniform ...
Blum, Helmut +9 more
core +5 more sources
Viral Mimicry of Cdc2/Cyclin-Dependent Kinase 1 Mediates Disruption of Nuclear Lamina during Human Cytomegalovirus Nuclear Egress [PDF]
PLoS Pathogens, 2009 The nuclear lamina is a major obstacle encountered by herpesvirus nucleocapsids in their passage from the nucleus to the cytoplasm (nuclear egress).
A Bubeck +72 more
core +5 more sources
The Prolyl Isomerase Pin1 Promotes the Herpesvirus-Induced Phosphorylation-Dependent Disassembly of the Nuclear Lamina Required for Nucleocytoplasmic Egress [PDF]
PLoS Pathogens, 2016 The nuclear lamina lines the inner nuclear membrane providing a structural framework for the nucleus. Cellular processes, such as nuclear envelope breakdown during mitosis or nuclear export of large ribonucleoprotein complexes, are functionally linked to
Jens Milbradt +10 more
openalex +3 more sources
PRR14 organizes H3K9me3-modified heterochromatin at the nuclear lamina
Nucleus, 2023 The eukaryotic genome is organized in three dimensions within the nucleus. Transcriptionally active chromatin is spatially separated from silent heterochromatin, a large fraction of which is located at the nuclear periphery.
Anna A. Kiseleva +4 more
openalex +3 more sources
Frontiers in Cell and Developmental Biology, 2022 Associations of chromatin with the nuclear lamina, at the nuclear periphery, help shape the genome in 3 dimensions. The genomic landscape of lamina-associated domains (LADs) is well characterized, but much remains unknown on the physical and mechanistic ...
Julia Madsen-Østerbye +5 more
doaj +1 more source
Structural and Mechanical Aberrations of the Nuclear Lamina in Disease
Cells, 2020 The nuclear lamins are the major components of the nuclear lamina in the nuclear envelope. Lamins are involved in numerous functions, including a role in providing structural support to the cell and the mechanosensing of the cell.
Merel Stiekema +3 more
doaj +1 more source
Nuclear shapes are geometrically determined by the excess surface area of the nuclear lamina
Frontiers in Cell and Developmental Biology, 2023 Introduction: Nuclei have characteristic shapes dependent on cell type, which are critical for proper cell function, and nuclei lose their distinct shapes in multiple diseases including cancer, laminopathies, and progeria.
Richard B. Dickinson +3 more
doaj +1 more source
Role of the Nuclear Lamina in Age-Associated Nuclear Reorganization and Inflammation
Cells, 2020 Aging is characterized by the gradual loss of tissue function and integrity. Activation of inflammatory responses accelerates the deterioration of cells and tissues.
Lidya Kristiani, Miri Kim, Youngjo Kim
doaj +1 more source
The meiotic nuclear lamina regulates chromosome dynamics and promotes efficient homologous recombination in the mouse. [PDF]
PLoS Genetics, 2013 The nuclear lamina is the structural scaffold of the nuclear envelope and is well known for its central role in nuclear organization and maintaining nuclear stability and shape.
Jana Link +7 more
doaj +1 more source
Dynamic nuclear structure emerges from chromatin crosslinks and motors [PDF]
Phys. Rev. Lett. 126, 158101 (2021), 2020 The cell nucleus houses the chromosomes, which are linked to a soft shell of lamin filaments. Experiments indicate that correlated chromosome dynamics and nuclear shape fluctuations arise from motor activity. To identify the physical mechanisms, we develop a model of an active, crosslinked Rouse chain bound to a polymeric shell. System-sized correlated
arxiv +1 more source