Results 21 to 30 of about 163,417 (257)
Surface Direct Conversion of 511 keV Gamma Rays in Large-Area Laminated Multichannel-Plate Electron Multipliers [PDF]
Nucl. Instrum. Meth. Vol. 1055 (Oct 2023) 168538, 2023 We have used the TOPAS simulation framework to model the direct conversion of 511 keV gamma rays to electrons in a micro-channel plate (MCP) constructed from thin laminae of a heavy-metal-loaded dielectric such as lead-glass, patterned with micro-channels (LMCP).
arxiv +1 more source
Cell Reports, 2013 The nuclear lamina is a protein meshwork that lies under the inner nuclear membrane of metazoan cells. One function of the nuclear lamina is to organize heterochromatin at the inner nuclear periphery.
Andrey Poleshko +5 more
doaj +1 more source
The Nuclear Lamina: Protein Accumulation and Disease
Biomedicines, 2020 Cellular health is reliant on proteostasis—the maintenance of protein levels regulated through multiple pathways modulating protein synthesis, degradation and clearance. Loss of proteostasis results in serious disease and is associated with aging.
Carla Almendáriz-Palacios +7 more
doaj +1 more source
The nuclear lamina binds the EBV genome during latency and regulates viral gene expression
PLoS Pathogens, 2022 The Epstein Barr virus (EBV) infects almost 95% of the population worldwide. While typically asymptomatic, EBV latent infection is associated with several malignancies of epithelial and lymphoid origin in immunocompromised individuals.
Lisa Beatrice Caruso +9 more
doaj +2 more sources
Mesoscale phase separation of chromatin in the nucleus [PDF]
, 2020 Intact-organism imaging of Drosophila larvae reveals and quantifies chromatin-aqueous phase separation. The chromatin can be organized near the lamina layer of the nuclear envelope, conventionally fill the nucleus, be organized centrally, or as a wetting droplet.
arxiv +1 more source
Baculovirus infection induces disruption of the nuclear lamina
Scientific Reports, 2017 Baculovirus nucleocapsids egress from the nucleus primarily via budding at the nuclear membrane. The nuclear lamina underlying the nuclear membrane represents a substantial barrier to nuclear egress. Whether the nuclear lamina undergoes disruption during
Xiaomei Zhang +5 more
doaj +1 more source
Towards understanding lamin gene regulation [PDF]
, 1994 The lamins are components of the nuclear lamina, which forms a fibrous meshwork lining the inner nuclear membrane. Lamina-membrane interactions play a crucial role during nuclear disassembly and reassembly at mitosis, whereas lamina-chromatin association
Hamid, Q. Anwar +2 more
core +1 more source
Photonics, 2020 Studying the architecture of nuclear lamina networks is significantly important in biomedicine owing not only to their influence on the genome, but also because they are associated with several diseases.
Yiwei Chen +8 more
doaj +1 more source
Chromatin and cytoskeletal tethering determine nuclear morphology in progerin expressing cells [PDF]
, 2020 The nuclear morphology of eukaryotic cells is determined by the interplay between the lamina forming the nuclear skeleton, the chromatin inside the nucleus and the coupling with the cytoskeleton. Nuclear alterations are often associated with pathological conditions as in the Hutchinson-Gilford progeria syndrome (HGPS) where a mutation in the lamin A ...
arxiv +1 more source
Low-Dose TOF-PET Based on Surface Electron Production in Dielectric Laminar MCPs [PDF]
Nucl. Instrum. Meth. Vol. 1057 (Dec 2023) 168676, 2023 We present simulations of whole-body low-dose time-of-flight positron emission tomography (TOF-PET) based on the direct surface production [1] by 511 keV gamma rays of energetic electrons via the Photo-electric and Compton Effects, eliminating the scintillator and photodetector sub-systems in PET scanners. In Ref.
arxiv +1 more source