Results 21 to 30 of about 1,676,612 (335)
The nuclear lamina binds the EBV genome during latency and regulates viral gene expression [PDF]
PLoS Pathogens, 2022 The Epstein Barr virus (EBV) infects almost 95% of the population worldwide. While typically asymptomatic, EBV latent infection is associated with several malignancies of epithelial and lymphoid origin in immunocompromised individuals.
Lisa Beatrice Caruso +9 more
doaj +3 more sources
3D Single Molecule Super-Resolution Microscopy of Whole Nuclear Lamina [PDF]
Frontiers in Chemistry, 2022 Single molecule (SM) super-resolution microscopies bypass the diffraction limit of conventional optical techniques and provide excellent spatial resolutions in the tens of nanometers without overly complex microscope hardware.
Ashley M. Rozario +7 more
doaj +2 more sources
mBio, 2012 Little is known about the mechanisms of gene targeting within the nucleus and its effect on gene expression, but most studies have concluded that genes located near the nuclear periphery are silenced by heterochromatin.
Lindsey Silva +5 more
doaj +2 more sources
Nuclear lamina integrity is required for proper spatial organization of chromatin in Drosophila
Nature Communications, 2019 The role of the nuclear lamina (NL) in chromatin architecture is still poorly understood. Here, the authors provide evidence that disruption of the NL in Drosophila cells leads to overall chromatin compaction and repositioning from the nuclear envelope ...
Sergey V. Ulianov +16 more
doaj +2 more sources
The Nuclear Lamina as an Organizer of Chromosome Architecture [PDF]
Cells, 2019 The nuclear lamina (NL) is a meshwork of lamins and lamin-associated proteins adjoining the inner side of the nuclear envelope. In early embryonic cells, the NL mainly suppresses background transcription, whereas, in differentiated cell types, its ...
Y. Y. Shevelyov, S. Ulianov
semanticscholar +5 more sources
The nuclear lamina in health and disease [PDF]
Nucleus, 2016 The nuclear lamina (NL) is a structural component of the nuclear envelope and makes extensive contacts with integral nuclear membrane proteins and chromatin.
A. Dobrzynska +3 more
semanticscholar +7 more sources
Baculovirus infection induces disruption of the nuclear lamina [PDF]
Scientific Reports, 2017 Baculovirus nucleocapsids egress from the nucleus primarily via budding at the nuclear membrane. The nuclear lamina underlying the nuclear membrane represents a substantial barrier to nuclear egress. Whether the nuclear lamina undergoes disruption during
Xiaomei Zhang +5 more
doaj +3 more sources
Polycomb-lamina antagonism partitions heterochromatin at the nuclear periphery
Nature Communications, 2022 Here the authors developed ‘Lamina-Inducible Methylation and Hi-C’ (LIMe-Hi-C) to simultaneously measure chromosome conformation, DNA methylation, and nuclear lamina positioning. Application of the method revealed dynamic changes upon PRC2 inhibition and
Allison P. Siegenfeld +8 more
doaj +2 more sources
Defective Nuclear Lamina in Aneuploidy and Carcinogenesis [PDF]
Frontiers in Oncology, 2018 Aneuploidy, loss or gain of whole chromosomes, is a prominent feature of carcinomas, and is generally considered to play an important role in the initiation and progression of cancer.
Elizabeth R. Smith +2 more
semanticscholar +5 more sources
Cell Reports, 2018 Summary: Tcrb locus V(D)J recombination is regulated by positioning at the nuclear periphery. Here, we used DamID to profile Tcrb locus interactions with the nuclear lamina at high resolution.
Shiwei Chen +7 more
doaj +2 more sources