Results 51 to 60 of about 13,819 (261)
The Journal of Cell Biology, 2000 At the end of mitosis, the nuclear lamins assemble to form the nuclear lamina during nuclear envelope formation in daughter cells. We have fused A- and B-type nuclear lamins to the green fluorescent protein to study this process in living cells. The results reveal that the A- and B-type lamins exhibit different pathways of assembly. In the early stages
Robert D. Moir +3 more
openaire +1 more source
Down-regulation of the Lamin A/C in neuroblastoma triggers the expansion of tumor initiating cells [PDF]
, 2015 Tumor-initiating cells constitute a population within a tumor mass that shares properties with normal stem cells and is considered responsible for therapy failure in many cancers.
AMENDOLA, Donatella +20 more
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Role of lamins in 3D genome organization and global gene expression
Nucleus, 2019 Genome-wide mapping of lamin-B1-genome interactions has shown that gene-poor and transcriptionally inactive genomic regions are associated with the nuclear lamina.
Youngjo Kim, Xiaobin Zheng, Yixian Zheng
doaj +1 more source
Characterization of lamin mutation phenotypes in Drosophila and comparison to human laminopathies. [PDF]
PLoS ONE, 2007 Lamins are intermediate filament proteins that make up the nuclear lamina, a matrix underlying the nuclear membrane in all metazoan cells that is important for nuclear form and function.
Andrés Muñoz-Alarcón +6 more
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The relationship of lamins with epigenetic factors during aging
Вавиловский журнал генетики и селекции, 2022 The key factor of genome instability during aging is transposon dysregulation. This may be due to senile changes in the expression of lamins, which epigenetically modulate transposons. Lamins directly physically interact with transposons.
R. N. Mustafin, E. K. Khusnutdinova
doaj +1 more source
Lamins A and C but Not Lamin B1 Regulate Nuclear Mechanics [PDF]
Journal of Biological Chemistry, 2006 Mutations in the nuclear envelope proteins lamins A and C cause a broad variety of human diseases, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy, and Hutchinson-Gilford progeria syndrome. Cells lacking lamins A and C have reduced nuclear stiffness and increased nuclear fragility, leading to increased cell death under mechanical ...
Jan, Lammerding +6 more
openaire +2 more sources
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Probing the environment of emerin by Enhanced ascorbate peroxidase 2 (APEX2)-mediated proximity labeling. [PDF]
, 2020 Emerin is one of the best characterized proteins of the inner nuclear membrane, but can also occur at the level of the endoplasmic reticulum. We now use enhanced ascorbate peroxidase 2 (APEX2) to probe the environment of emerin.
James, C. +4 more
core +1 more source
Mechanoregulatory Effects of Cell‐Scale Microwells on Epithelial Cell Phenotype
Advanced Functional Materials, EarlyView.In small polycaprolactone microwells, A549 epithelial cells span well edges, in contrast to cells growing on flat substrates. Focal adhesion sites (yellow) concentrate at topographic boundaries, while cytoskeletal tension (magenta stress fibers) is transmitted to the nucleus (blue), reducing nuclear sphericity.
Ruiwen He +10 more
wiley +1 more source
Weaving a pattern from disparate threads: lamin function in nuclear assembly and DNA replication [PDF]
, 1994 The major residual structure that remains associated with the nuclear envelope following extraction of isolated nuclei or oocyte germinal vesicles with non-ionic detergents, nucleases and high salt is the lamina (Fawcett, 1966; Aaronson and Blobel ...
Bridger, JM +3 more
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