Results 51 to 60 of about 7,287 (212)
Drosophila Models Reveal Properties of Mutant Lamins That Give Rise to Distinct Diseases
Cells, 2023 Mutations in the LMNA gene cause a collection of diseases known as laminopathies, including muscular dystrophies, lipodystrophies, and early-onset aging syndromes.
Sydney G. Walker +4 more
doaj +1 more source
Structural organization of the human gene encoding nuclear lamin A and nuclear lamin C
Journal of Biological Chemistry, 1993 We have determined the structural organization of the human gene that encodes nuclear lamins A and C, intermediate filament proteins of the nuclear lamina. Sequencing and restriction mapping show that the coding region spans approximately 24 kilobases.
F, Lin, H J, Worman
openaire +2 more sources
Structure of the Globular Tail of Nuclear Lamin [PDF]
Journal of Biological Chemistry, 2002 The nuclear lamins form a two-dimensional matrix that provides integrity to the cell nucleus and participates in nuclear activities. Mutations in the region of human LMNA encoding the carboxyl-terminal tail Lamin A/C are associated with forms of muscular dystrophy and familial partial lipodystrophy (FPLD).
Sirano, Dhe-Paganon +3 more
openaire +2 more sources
Advanced Functional Materials, EarlyView.A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo +7 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz +9 more
wiley +1 more source
Advanced Materials, EarlyView.Cancer‐associated NPC remodeling creates a high‐flux, low‐stringency nuclear state that supports malignant adaptation but increases mechanical fragility. Targeting the FG‐barrier or NPC scaffold may drive mechanostat failure, envelope rupture, DNA damage, and loss of nuclear integrity.
Sílvio Terra Stefanello +5 more
wiley +1 more source
Characterization of lamin mutation phenotypes in Drosophila and comparison to human laminopathies. [PDF]
PLoS ONE, 2007 Lamins are intermediate filament proteins that make up the nuclear lamina, a matrix underlying the nuclear membrane in all metazoan cells that is important for nuclear form and function.
Andrés Muñoz-Alarcón +6 more
doaj +1 more source
The relationship of lamins with epigenetic factors during aging
Вавиловский журнал генетики и селекции, 2022 The key factor of genome instability during aging is transposon dysregulation. This may be due to senile changes in the expression of lamins, which epigenetically modulate transposons. Lamins directly physically interact with transposons.
R. N. Mustafin, E. K. Khusnutdinova
doaj +1 more source
Nuclear Lamins in Cell Regulation and Disease [PDF]
Cold Spring Harbor Symposia on Quantitative Biology, 2010 The nuclear lamins are type V intermediate filament proteins that form meshworks at the inner aspect of the nuclear envelope and are also present throughout the nuclear interior. Through these meshwork structures, lamins regulate the shape, size, and mechanical properties of the nucleus.
T, Shimi +3 more
openaire +2 more sources
Advanced Science, EarlyView.PRC2.1(PCL2)‐coordinated H3K27me3‐enriched PNH establishes a spatial scaffold crucial for nucleolar integrity. As a crucial coordinator, PCL2 links PRC2.1 to chromatin organization and NPM1 assembly. This network‐based model reveals how chromatin modifications and nucleolar components cooperatively maintain nucleolar architecture, revealing novel ...
Lina Zhu +12 more
wiley +1 more source