Results 201 to 210 of about 324,731 (284)

The Potential of Nuclear Pore Complexes in Cancer Therapy. [PDF]

Molecules
Zaitsava H, Gachowska M, Bartoszewska E, Kmiecik A, Kulbacka J.   +4 more
europepmc   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Detecting Nuclear Pore Complex assembly in living cells

Veldsink AC, Fischer JS, Terpstra HM, Mannino P, de Lange EM, Hell S, van Benthem KJ, Saba LJ, Steen A, Vlijm R, Heinemann M, Weis K, Lusk CP, Veenhoff LM.   +13 more
europepmc   +1 more source

HIV-1 nuclear import is selective and depends on both capsid elasticity and nuclear pore adaptability. [PDF]

Nat Microbiol
Hou Z, Shen Y, Fronik S, Shen J, Shi J, Xu J, Chen L, Hardenbrook N, Engelman AN, Aiken C, Zhang P.   +10 more
europepmc   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Integrative spatiotemporal modeling of biomolecular processes: Application to the assembly of the nuclear pore complex. [PDF]

Proc Natl Acad Sci U S A
Latham AP, Zhang W, Tempkin JOB, Otsuka S, Ellenberg J, Sali A.   +5 more
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

A conserved mechanism of membrane fusion in nuclear pore complex assembly

Fischer JS, Wojtynek M, Kumar A, Baird H, Radilova K, Maslennikova D, Ramachandran K, Becker AN, Agote-Aran A, Loffreda A, Kralt A, Jagannathan M, Dey G, Kutay U, Vanni S, Weis K.   +15 more
europepmc   +1 more source

The leader proteins of Theiler's virus and Boone cardiovirus use a combination of short linear motifs (SLiMs) to target RSK kinases to the nuclear pore complex. [PDF]

J Virol
Lizcano-Perret B, Wavreil F, Veinstein M, Duflos C, Milcamps R, Sorgeloos F, Michiels T.   +6 more
europepmc   +1 more source