Results 61 to 70 of about 2,343,531 (340)
Nup98-dependent transcriptional memory is established independently of transcription
eLife, 2022 Cellular ability to mount an enhanced transcriptional response upon repeated exposure to external cues is termed transcriptional memory, which can be maintained epigenetically through cell divisions and can depend on a nuclear pore component Nup98.
Pau Pascual-Garcia +2 more
doaj +1 more source
Integrative Structure and Functional Anatomy of a Nuclear Pore Complex
Nature, 2018 Nuclear pore complexes play central roles as gatekeepers of RNA and protein transport between the cytoplasm and nucleoplasm. However, their large size and dynamic nature have impeded a full structural and functional elucidation.
Seung Joong Kim +31 more
semanticscholar +1 more source
Nature Communications, 2019 Although defects in nucleocytoplasmic transport (NCT) may be central to the pathogenesis of ALS, the molecular mechanisms modulating the nuclear pore function are still largely unknown.
Anthony Giampetruzzi +8 more
doaj +1 more source
eLife, 2022 For some inducible genes, the rate and molecular mechanism of transcriptional activation depend on the prior experiences of the cell. This phenomenon, called epigenetic transcriptional memory, accelerates reactivation, and requires both changes in ...
Bethany Sump +4 more
doaj +1 more source
The subnuclear localization of tRNA ligase in yeast [PDF]
, 1987 Yeast tRNA ligase is an enzyme required for tRNA splicing. A study by indirect immune fluorescence shows that this enzyme is localized in the cell nucleus. At higher resolution, studies using indirect immune electron microscopy show this nuclear location
Abelson, John, Clark, Michael W.
core +1 more source
Three-dimensional structure and flexibility of a membrane-coating module of the nuclear pore complex. [PDF]
, 2009 The nuclear pore complex mediates nucleocytoplasmic transport in all eukaryotes and is among the largest cellular assemblies of proteins, collectively known as nucleoporins. Nucleoporins are organized into distinct subcomplexes.
Blobel, Günter, Kampmann, Martin
core +2 more sources
Nuclear Pore Complex Structure [PDF]
Developmental Cell, 2004 Nuclear pore complexes (NPCs) are large protein assemblies embedded in the nuclear envelope that act as passageways for transport of molecules into and out of the nucleus. Two new studies, one in Nature Cell Biology and one in Science , offer direct evidence that the NPC is a highly dynamic structure.
openaire +4 more sources
Structure and Assembly of the Nuclear Pore Complex.
Annual Review of Biophysics, 2019 Nuclear pore complexes (NPCs) mediate nucleocytoplasmic exchange. They are exceptionally large protein complexes that fuse the inner and outer nuclear membranes to form channels across the nuclear envelope.
Bernhard Hampoelz +3 more
semanticscholar +1 more source
Early Steps of Hepatitis B Life Cycle: From Capsid Nuclear Import to cccDNA Formation
Viruses, 2021 Hepatitis B virus (HBV) remains a major public health concern, with more than 250 million chronically infected people who are at high risk of developing liver diseases, including cirrhosis and hepatocellular carcinoma.
João Diogo Dias +2 more
doaj +1 more source
Explicit calculation of nuclear magnetic resonance relaxation rates in small pores to elucidate molecular scale fluid dynamics [PDF]
Phys. Rev. E 95, 033117 (2017), 2016 A model linking the molecular-scale dynamics of fluids confined to nano-pores to nuclear magnetic resonance (NMR) relaxation rates is proposed. The model is fit to experimental NMR dispersions for water and oil in an oil shale assuming that each fluid is characterised by three time constants and L\'{e}vy statistics.
arxiv +1 more source