Results 61 to 70 of about 2,248,811 (276)
Sorting with Disorder at Nuclear Pores [PDF]
Biophysical Journal, 2012 Macromolecular traffic between the nucleus and cytoplasm of cells is mediated by karyopherins and is gated at nuclear pores (NPCs) by intrinsically-disordered proteins featuring phenylalanine-glycine repeats: the FG nucleoporins. Despite their dynamic nature, these FG nups adopt distinct categories of disordered structure with unique functions.
Sean Newsam +8 more
openaire +2 more sources
Modeling of the mechano-chemical behavior of the nuclear pore complex: current research and perspectives [PDF]
, 2016 Recent evidence suggests that mechanical deformation of the cell nucleus regulates the nuclear import of the transcriptional activators of genes involved in primary physiological cell responses such as stem cell differentiation. In addition, this nuclear
Garcia, B +2 more
core +1 more source
eLife, 2019 Nuclear entry of HIV-1 replication complexes through intact nuclear pore complexes is critical for successful infection. The host protein cleavage-and-polyadenylation-specificity-factor-6 (CPSF6) has been implicated in different stages of early HIV-1 ...
D. Bejarano +9 more
semanticscholar +1 more source
Clathrate formation and dissociation in vapor/water/ice/hydrate systems in SBA-15, sol-gel and CPG porous media, as probed by NMR relaxation, novel protocol NMR cryoporometry, neutron scattering and ab initio quantum-mechanical molecular dynamics simulation [PDF]
, 2007 The Gibbs-Thomson effect modifies the pressure and temperature at which clathrates occur, hence altering the depth at which they occur in the seabed. Nuclear magnetic resonance (NMR) measurements as a function of temperature are being conducted for water/
Anderson, Ross A. +3 more
core +1 more source
ON THE ATTACHMENT OF THE NUCLEAR PORE COMPLEX [PDF]
The Journal of Cell Biology, 1974 Electron microscope examination of isolated rat liver nuclei after treatment with the detergent Triton X-100 revealed the complete removal of both the inner and outer membranes of the nuclear envelope. The envelope-denuded nuclei did not show any change in either shape or internal ultrastructure.
Robert Peter Aaronson, Günter Blobel
openaire +3 more sources
TFEB/Mitf links impaired nuclear import to autophagolysosomal dysfunction in C9-ALS
eLife, 2020 Disrupted nucleocytoplasmic transport (NCT) has been implicated in neurodegenerative disease pathogenesis; however, the mechanisms by which disrupted NCT causes neurodegeneration remain unclear.
Kathleen M Cunningham +13 more
doaj +1 more source
Structure-function mapping of a heptameric module in the nuclear pore complex. [PDF]
, 2012 The nuclear pore complex (NPC) is a multiprotein assembly that serves as the sole mediator of nucleocytoplasmic exchange in eukaryotic cells. In this paper, we use an integrative approach to determine the structure of an essential component of the yeast ...
Chait, Brian T +10 more
core +2 more sources
The liquid state of FG-nucleoporins mimics permeability barrier properties of nuclear pore complexes
Journal of Cell Biology, 2019 Nuclear pore complexes form a permeability barrier in vivo that regulates nucleocytoplasmic transport. Here, the authors present a microfluidic device that couples rapid liquid–liquid phase separation of nucleoporins with direct optical interrogation ...
G. Celetti +5 more
semanticscholar +1 more source
Cell Reports, 2020 Summary: The nuclear pore complex forms a highly crowded selective barrier with intrinsically disordered regions at the nuclear membrane to coordinate nucleocytoplasmic molecular communications.
Wanzhen Zhang +5 more
doaj
Nature Communications, 2020 In yeast, collapsed forks shift to the nuclear periphery to associate with two distinct perinuclear anchorage sites such as the nuclear pore complex. Here, the authors reveal the mechanisms engaged at nuclear pore complex facilitating fork integrity and ...
Karol Kramarz +7 more
doaj +1 more source