Results 71 to 80 of about 2,248,811 (276)

Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle. [PDF]

, 2019
Migration through 3D constrictions can cause nuclear rupture and mislocalization of nuclear proteins, but damage to DNA remains uncertain, as does any effect on cell cycle.
Bannister, Beadle, Belin, Bennett, Britton, Buxboim, Charlotte R. Pfeifer, Cho, Cornelius, Cumming, Dazhen Liu, Denais, Dennis E. Discher, Dong, Duheron, Emily J. Chen, Frigault, Garay, Giese, Gomes, Grundy, Harada, Harding, Hatch, Houtgraaf, Imlay, Irena L. Ivanovska, Irianto, Irianto, Ivkovic, Jerome Irianto, Kalia Pannell, Khatau, Kryston, Kuangzheng Zhu, Lawrence J. Dooling, Lee, Liu, Liu, Lu, Lucas R. Smith, López-Bigas, Maciejowski, Mahaseth, Mai Wang, Mavrakis, Mello Filho, Michael P. Tobin, Mogilner, Morita, Pajerowski, Pathak, Petrie, Pfeifer, Pfeifer, Raab, Raab, Radisky, Rancati, Rice, Rico, Rizvi, Roger A. Greenberg, Sancar, Skamagki, Strano, Stroka, Surcel, Takaki, Thiam, Thomas, Turgay, Wang, Wolf, Xia, Yan, Yuntao Xia, Zhang   +77 more
core   +1 more source

TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD

Alzheimer's & Dementia, 2017
The cytoplasmic mislocalization and aggregation of TAR DNA-binding protein-43 (TDP-43) is a common histopathological hallmark of the amyotrophic lateral sclerosis and frontotemporal dementia disease spectrum (ALS/FTD).
Ching-Chieh Chou, Y. Zhang, Mfon E Umoh, Spencer Vaughan, Ileana Lorenzini, Feilin Liu, Melissa R. Sayegh, Paul G. Donlin-Asp, Yu Han Chen, D. Duong, N. Seyfried, M. Powers, Thomas Kukar, Chadwick M. Hales, M. Gearing, N. Cairns, K. Boylan, D. Dickson, R. Rademakers, Yong-Jie Zhang, L. Petrucelli, R. Sattler, Daniela C. Zarnescu, J. Glass, W. Rossoll   +24 more
semanticscholar   +1 more source

Evolutionarily Conserved Sequence Features Regulate the Formation of the FG Network at the Center of the Nuclear Pore Complex. [PDF]

, 2015
The nuclear pore complex (NPC) is the portal for bidirectional transportation of cargos between the nucleus and the cytoplasm. While most of the structural elements of the NPC, i.e.
Lee, BL, Mofrad, MRK, Peyro, M, Soheilypour, M   +3 more
core   +2 more sources

Nuclear Import of Hepatitis B Virus Capsids and Genome

Viruses, 2017
Hepatitis B virus (HBV) is an enveloped pararetrovirus with a DNA genome, which is found in an up to 36 nm-measuring capsid. Replication of the genome occurs via an RNA intermediate, which is synthesized in the nucleus.
Lara Gallucci, Michael Kann
doaj   +1 more source

Bistable collective behavior of polymers tethered in a nanopore. [PDF]

, 2012
Polymer-coated pores play a crucial role in nucleo-cytoplasmic transport and in a number of biomimetic and nanotechnological applications. Here we present Monte Carlo and Density Functional Theory approaches to identify different collective phases of end-
Bailey, J, Fassati, A, Ford, IJ, Harker, AH, Hoogenboom, BW, Osmanovic, D   +5 more
core   +2 more sources

In situ architecture of the algal nuclear pore complex

Nature Communications, 2018
Nuclear pore complexes (NPCs) span the nuclear envelope and mediate nucleocytoplasmic exchange. They are a hallmark of eukaryotes and deeply rooted in the evolutionary origin of cellular compartmentalization.
S. Mosalaganti, J. Kosiński, S. Albert, M. Schaffer, Daniela Strenkert, Patrice A. Salomé, S. Merchant, J. Plitzko, W. Baumeister, B. Engel, Martin Beck   +10 more
semanticscholar   +1 more source

Nuclear pore protein NUP210 depletion suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response

Nature Communications, 2021
The involvement of nuclear pore proteins in cellular mechanosensing and metastasis is unclear. Here the authors identify that nuclear pore protein NUP210 promotes metastasis through the interaction with mechanotransducer LINC complex protein and ...
Ruhul Amin, Anjali Shukla, Jacqueline Jufen Zhu, Sohyoung Kim, Ping Wang, Simon Zhongyuan Tian, Andy D. Tran, Debasish Paul, Steven D. Cappell, Sandra Burkett, Huaitian Liu, Maxwell P. Lee, Michael J. Kruhlak, Jennifer E. Dwyer, R. Mark Simpson, Gordon L. Hager, Yijun Ruan, Kent W. Hunter   +17 more
doaj   +1 more source

AFM imaging of functionalized carbon nanotubes on biological membranes [PDF]

, 2009
Multifunctional carbon nanotubes are promising for biomedical applications as their nano-size, together with their physical stability, gives access into the cell and various cellular compartments including the nucleus.
Coley, Helen M., Danzberger, Jürgen, Ebner, Andreas, Flahaut, Emmanuel, Gruber, Hermann J., Heister, Elena, Hinterdorfer, Peter, Kienberger, Ferry, Lamprecht, Constanze, Liashkovich, I., McFadden, Johnjoe, Neves, Vera, Rangl, Martina   +12 more
core   +1 more source

DNA origami scaffold for studying intrinsically disordered proteins of the nuclear pore complex

Nature Communications, 2018
The nuclear pore complex (NPC) is the gatekeeper for nuclear transport in eukaryotic cells. A key component of the NPC is the central shaft lined with intrinsically disordered proteins (IDPs) known as FG-Nups, which control the selective molecular ...
Philip Ketterer, A. Ananth, D. S. Laman Trip, Ankur Mishra, E. Bertosin, M. Ganji, Jaco van der Torre, P. Onck, Hendrik Dietz, C. Dekker   +9 more
semanticscholar   +1 more source

Segregation of yeast nuclear pores [PDF]

Nature, 2010
During mitosis in Saccharomyces cerevisiae, senescence factors such as extrachromosomal ribosomal DNA circles (ERCs) are retained in the mother cell and excluded from the bud/daughter cell. Shcheprova et al. proposed a model suggesting segregation of ERCs through their association with nuclear pore complexes (NPCs) and retention of pre-existing NPCs in
Anton Khmelinskii, Michael Knop, Philipp J. Keller, Elmar Schiebel, Holger Lorenz   +4 more
openaire   +3 more sources