Results 71 to 80 of about 2,343,531 (340)

Sorting with Disorder at Nuclear Pores [PDF]

Biophysical Journal, 2012
Macromolecular traffic between the nucleus and cytoplasm of cells is mediated by karyopherins and is gated at nuclear pores (NPCs) by intrinsically-disordered proteins featuring phenylalanine-glycine repeats: the FG nucleoporins. Despite their dynamic nature, these FG nups adopt distinct categories of disordered structure with unique functions.
Sean Newsam, Ed Lau, Ajay Gopinathan, Michael Rexach, Michael E. Colvin, Justin Yamada, Krish Krishnan, Vladimir N. Uversky, Joshua L. Phillips   +8 more
openaire   +2 more sources

An agent-based model for mRNA export through the nuclear pore complex. [PDF]

, 2014
mRNA export from the nucleus is an essential step in the expression of every protein- coding gene in eukaryotes, but many aspects of this process remain poorly understood.
Azimi, Mohammad, Bulat, Evgeny, Mofrad, Mohammad RK, Weis, Karsten   +3 more
core   +2 more sources

HIV-1 nuclear import in macrophages is regulated by CPSF6-capsid interactions at the nuclear pore complex

eLife, 2019
Nuclear entry of HIV-1 replication complexes through intact nuclear pore complexes is critical for successful infection. The host protein cleavage-and-polyadenylation-specificity-factor-6 (CPSF6) has been implicated in different stages of early HIV-1 ...
D. Bejarano, K. Peng, V. Laketa, Kathleen Börner, K Laurence Jost, Bojana Lucic, B. Glass, M. Lusic, B. Müller, H. Kräusslich   +9 more
semanticscholar   +1 more source

The liquid state of FG-nucleoporins mimics permeability barrier properties of nuclear pore complexes

Journal of Cell Biology, 2019
Nuclear pore complexes form a permeability barrier in vivo that regulates nucleocytoplasmic transport. Here, the authors present a microfluidic device that couples rapid liquid–liquid phase separation of nucleoporins with direct optical interrogation ...
G. Celetti, G. Paci, Joana Caria, V. Vandelinder, G. Bachand, E. Lemke   +5 more
semanticscholar   +1 more source

Modeling of the mechano-chemical behavior of the nuclear pore complex: current research and perspectives [PDF]

, 2016
Recent evidence suggests that mechanical deformation of the cell nucleus regulates the nuclear import of the transcriptional activators of genes involved in primary physiological cell responses such as stem cell differentiation. In addition, this nuclear
Garcia, B, RAIMONDI, MANUELA TERESA, RODRIGUEZ MATAS, JOSE FELIX   +2 more
core   +1 more source

Evolution of the nucleus [PDF]

, 2014
Under a Creative Commons license.The nucleus represents a major evolutionary transition. As a consequence of separating translation from transcription many new functions arose, which likely contributed to the remarkable success of eukaryotic cells.
Adl, Alber, Alberts, Andersen, Basto, Batsios, Bornens, Carvalho-Santos, Carvalho-Santos, Cavalier-Smith, Ciska, Cook, Cronshaw, Dahl, Damien P Devos, Daunderer, De Souza, Debec, Degrasse, Devos, Devos, Ding, Ding, Dittmer, Doucet, DuBois, Embley, Feldherr, Field, Field, Field, Flemming, Friedländer, Gribaldo, Haque, Hartman, Hodges, Hoelz, Hozák, Iwamoto, Kaller, Khodjakov, Khodjakov, King, Koumandou, Krüger, Kuhnert, Lee, Leeson, Li, Lindås, Low, Lu, Makarova, Malone, Mana-Capelli, Mans, Mark C Field, Meier, Neumann, Omer, Pace, Pan, Pearson, Pereira, Pickett-Heaps, Ralph Gräf, Ratcliffe, Rothballer, Rout, Salgado-Garrido, Samson, Sandman, Santarella-Mellwig, Santarella-Mellwig, Schmidt, Schneider, Schulz, Shimi, Starr, Stewart-Hutchinson, Still, Tamura, Tetenbaum-Novatt, Ueda, Wilson, Worman, Xiong, Xu, Zhou   +89 more
core   +3 more sources

Temporal Changes in Nuclear Envelope Permeability during Semi-Closed Mitosis in Dictyostelium Amoebae

Cells, 2023
The Amoebozoan Dictyostelium discoideum exhibits a semi-closed mitosis in which the nuclear membranes remain intact but become permeabilized to allow tubulin and spindle assembly factors to access the nuclear interior.
Kristina Mitic, Irene Meyer, Ralph Gräf, Marianne Grafe   +3 more
doaj   +1 more source

Segregation of yeast nuclear pores [PDF]

Nature, 2010
During mitosis in Saccharomyces cerevisiae, senescence factors such as extrachromosomal ribosomal DNA circles (ERCs) are retained in the mother cell and excluded from the bud/daughter cell. Shcheprova et al. proposed a model suggesting segregation of ERCs through their association with nuclear pore complexes (NPCs) and retention of pre-existing NPCs in
Anton Khmelinskii, Michael Knop, Philipp J. Keller, Elmar Schiebel, Holger Lorenz   +4 more
openaire   +3 more sources

In situ architecture of the algal nuclear pore complex

Nature Communications, 2018
Nuclear pore complexes (NPCs) span the nuclear envelope and mediate nucleocytoplasmic exchange. They are a hallmark of eukaryotes and deeply rooted in the evolutionary origin of cellular compartmentalization.
S. Mosalaganti, J. Kosiński, S. Albert, M. Schaffer, Daniela Strenkert, Patrice A. Salomé, S. Merchant, J. Plitzko, W. Baumeister, B. Engel, Martin Beck   +10 more
semanticscholar   +1 more source

The molecular mechanism of nuclear transport revealed by atomic-scale measurements

eLife, 2015
Nuclear pore complexes (NPCs) form a selective filter that allows the rapid passage of transport factors (TFs) and their cargoes across the nuclear envelope, while blocking the passage of other macromolecules.
Loren E Hough, Kaushik Dutta, Samuel Sparks, Deniz B Temel, Alia Kamal, Jaclyn Tetenbaum-Novatt, Michael P Rout, David Cowburn   +7 more
doaj   +1 more source