Results 81 to 90 of about 2,248,811 (276)

Nuclear Pore Proteins in Regulation of Chromatin State

Cells, 2019
Nuclear pore complexes (NPCs) are canonically known to regulate nucleocytoplasmic transport. However, research efforts over the last decade have demonstrated that NPCs and their constituent nucleoporins (Nups) also interact with the genome and perform ...
Terra M. Kuhn, Maya Capelson
doaj   +1 more source

Nuclear Pore Complexes Cluster in Dysmorphic Nuclei of Normal and Progeria Cells during Replicative Senescence

Cells, 2021
Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disease caused by a mutation in LMNA. A G608G mutation in exon 11 of LMNA is responsible for most HGPS cases, generating a truncated protein called “progerin”.
Jennifer M. Röhrl, Rouven Arnold, Karima Djabali   +2 more
doaj   +1 more source

Diffusion of Macromolecules across the Nuclear Pore Complex

, 2007
Nuclear pore complexes (NPCs) are very selective filters that monitor the transport between the cytoplasm and the nucleoplasm. Two models have been suggested for the plug of the NPC. They are (i) it is a reversible hydrogel or (ii) it is a polymer brush.
Alber, Alber, Ananya Debnath, Banik, Ben-Efraim, Bhattacharjee, Bickel, Cardarelli, Cardarelli, Chakrabarti, Chakrabarti, Chatterjee, Das, Doi, Elbaum, Fahrenkrog, Feldherr, Fiserova, Frey, Frey, Grünwald, Görlich, Herrman, Isgro, Isgro, Isgro, Justin Yamada, K.L. Sebastian, Kawakatsu, Keminer, Kim, Koutsioubas, Kowalczyk, Kraikvski, Kraikvski, Kubitscheck, Kustanovich, Landau, Leitenberger, Lim, Lim, Liu, Lowe, Ma, Ma, Maarel, Marcerou, Milner, Moussavi-Baygi, Moussavi-Baygi, Nielsen, Paine, Patel, Peters, Rajaraman, Rajarshi Chakrabarti, Reister, Ribbeck, Rout, Rout, Sebastian, Sebastian, Sebastian, Sprakel, Sprakel, Tabatabaei, Tran, Weise, Xu, Yang, Zilman, Zinn-Justin   +71 more
core   +1 more source

Nuclear pore density controls heterochromatin reorganization during senescence

bioRxiv, 2018
Oncogene induced senescence (OIS) is a cell cycle arrest program triggered by oncogenic signalling. An important characteristic of OIS is activation of the senescence associated secretory phenotype (SASP)1 which can reinforce cell cycle arrest, lead to ...
Charlene Boumendilrid, P. Hari, K. Olsen, J. Acosta, W. Bickmore   +4 more
semanticscholar   +1 more source

Human RTEL1 Interacts with KPNB1 (Importin β) and NUP153 and Connects Nuclear Import to Nuclear Envelope Stability in S-Phase

Cells, 2023
Regulator of TElomere Length Helicase 1 (RTEL1) is a helicase required for telomere maintenance and genome replication and repair. RTEL1 has been previously shown to participate in the nuclear export of small nuclear RNAs.
Michael Schertzer, Laurent Jullien, André L. Pinto, Rodrigo T. Calado, Patrick Revy, Arturo Londoño-Vallejo   +5 more
doaj   +1 more source

Pore timing:the evolutionary origins of the nucleus and nuclear pore complex [PDF]

, 2019
The name “eukaryote” is derived from Greek, meaning “true kernel”, and describes the domain of organisms whose cells have a nucleus. The nucleus is thus the defining feature of eukaryotes and distinguishes them from prokaryotes (Archaea and Bacteria ...
A Noble, A O'Reilly, A Ori, A Pittis, A Poole, A Spang, A von Appen, C Klinger, D Devos, D Devos, D Lin, E Arakel, E Szathmáry, F Alber, G Dey, G Holzer, H Asakawa, J Cronshaw, J Dacks, J Dacks, J DeGrasse, J Fischer, J Gomez-Cavazos, J Holden, J Kosinski, K Knockenhauer, K Leung, K Tamura, K Zaremba-Niedzwiedzka, M Beck, M Beck, M D'Angelo, M Eibauer, M Faini, M Field, M Field, M Field, M Iwamoto, M Paraan, M Raices, M Robinson, M Rout, M Rout, N Yutin, P Sampathkumar, R Hayama, R Teimer, S Dodonova, S Fath, S Kim, S Mosalaganti, S Obado, S Obado, T Jovanovic-Talisman, T Ritterhoff, T Stuwe, V Sakin, W Martin, W Martin, Y Bykov   +59 more
core   +3 more sources

Simple rules for passive diffusion through the nuclear pore complex

Journal of Cell Biology, 2016
Passive macromolecular diffusion through nuclear pore complexes is thought to decrease dramatically beyond ∼40 kD. Using time-resolved fluorescence microscopy and Brownian dynamics simulations, Timney et al. show that this barrier is in fact much softer,
Benjamin L Timney, Barak Raveh, Roxana Mironska, Jill Trivedi, Seung Joong Kim, Daniel Russel, S. Wente, A. Sali, M. Rout   +8 more
semanticscholar   +1 more source

The effect of cell morphology on the permeability of the nuclear envelope to diffusive factors [PDF]

, 2018
A recent advance in understanding stem cell differentiation is that the cell is able to translate its morphology, i.e., roundish or spread, into a fate decision.
García González, Alberto, Jacchetti, Emanuela, Marotta, Roberto   +2 more
core   +2 more sources

An Efficient Method for Isolating and Purifying Nuclei from Mice Brain for Single-Molecule Imaging Using High-Speed Atomic Force Microscopy

Cells
Nuclear pore complexes (NPCs) on the nuclear membrane surface have a crucial function in controlling the movement of small molecules and macromolecules between the cell nucleus and cytoplasm through their intricate core channel resembling a spiderweb ...
Yujia Qiu, Elma Sakinatus Sajidah, Sota Kondo, Shinnosuke Narimatsu, Muhammad Isman Sandira, Yoshiki Higashiguchi, Goro Nishide, Azuma Taoka, Masaharu Hazawa, Yuka Inaba, Hiroshi Inoue, Ayami Matsushima, Yuki Okada, Mitsutoshi Nakada, Toshio Ando, Keesiang Lim, Richard W. Wong   +16 more
doaj   +1 more source

Influence of sediment redox conditions on uranium mobilisation during saline intrusion [PDF]

, 2013
This research was funded by the Natural Environment Research Council (grant NE/C506799/1: Studentship NE/H527116/1).In the UK, several coastal nuclear sites have been identified as vulnerable to future sea level rise.
Blake, WH, Eagling, J, Keith-Roach, MJ, Worsfold, PJ   +3 more
core   +2 more sources