Results 1 to 10 of about 294,484 (344)

Nuclear Pore Complex [PDF]

Definitions, 2020
National Cancer Institute
semanticscholar   +3 more sources

Nuclear warfare: pathogen manipulation of the nuclear pore complex and nuclear functions [PDF]

mBio
Viruses and bacteria exploit the nuclear pore complex (NPC) and host nuclear functions to bypass cellular barriers and manipulate essential processes. Viruses frequently engage directly with NPC components, such as nucleoporins, to enable genome import ...
Brianna Steiert, Mary M. Weber
doaj   +2 more sources

An amphipathic helix in Brl1 is required for nuclear pore complex biogenesis in S. cerevisiae

eLife, 2022
The nuclear pore complex (NPC) is the central portal for macromolecular exchange between the nucleus and cytoplasm. In all eukaryotes, NPCs assemble into an intact nuclear envelope (NE) during interphase, but the process of NPC biogenesis remains poorly ...
Annemarie Kralt, Matthias Wojtynek, Jonas S Fischer, Arantxa Agote-Aran, Roberta Mancini, Elisa Dultz, Elad Noor, Federico Uliana, Marianna Tatarek-Nossol, Wolfram Antonin, Evgeny Onischenko, Ohad Medalia, Karsten Weis   +12 more
doaj   +3 more sources

Uip4p modulates nuclear pore complex function in Saccharomyces cerevisiae [PDF]

Nucleus, 2022
A double membrane bilayer perforated by nuclear pore complexes (NPCs) governs the shape of the nucleus, the prominent distinguishing organelle of a eukaryotic cell.
Pallavi Deolal, Imlitoshi Jamir, Krishnaveni Mishra   +2 more
doaj   +2 more sources

Nuclear pore complex dysfunction drives TDP-43 pathology in ALS [PDF]

Redox Biology
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive motor neuron degeneration and pathological aggregation of TDP-43. While protein misfolding and impaired autophagy are established features, accumulating
O. Ramírez-Núñez, S. Rico-Ríos, P. Torres, V. Ayala, A. Fernàndez-Bernal, M. Ceron-Codorniu, P. Andrés-Benito, A. Vinyals, S. Maqsood, I. Ferrer, R. Pamplona, M. Portero-Otin   +11 more
doaj   +2 more sources

Caspase-mediated nuclear pore complex trimming in cell differentiation and endoplasmic reticulum stress [PDF]

eLife, 2023
During apoptosis, caspases degrade 8 out of ~30 nucleoporins to irreversibly demolish the nuclear pore complex. However, for poorly understood reasons, caspases are also activated during cell differentiation.
Ukrae H Cho, Martin W Hetzer
doaj   +2 more sources

RNA export through the nuclear pore complex is directional [PDF]

Nature Communications, 2022
There is little information on export directionality of RNA passing through the nuclear pore complex in human cells. Here, the authors examine single RNA molecules in transit, to demonstrate 5’-first directionality for the export of mRNA and lncRNA.
Asaf Ashkenazy-Titelman, Mohammad Khaled Atrash, Alon Boocholez, Noa Kinor, Yaron Shav-Tal   +4 more
doaj   +2 more sources

Nuclear pore complex proteins are involved in centromere distribution [PDF]

iScience
Summary: The subnuclear distribution of centromeres is cooperatively regulated by condensin II and the linker of nucleoskeleton and cytoskeleton (LINC) complex.
Nanami Ito, Takuya Sakamoto, Yuka Oko, Hikaru Sato, Shigeru Hanamata, Yuki Sakamoto, Sachihiro Matsunaga   +6 more
doaj   +2 more sources

Elucidating the nanoscopic organization and dynamics of the nuclear pore complex [PDF]

Nucleus
Baumann K, Bertosin E, Barth A, Dekker C, Lim R.   +4 more
europepmc   +2 more sources

Integrative spatiotemporal modeling of biomolecular processes: Application to the assembly of the nuclear pore complex. [PDF]

Proc Natl Acad Sci U S A
Latham AP, Zhang W, Tempkin JOB, Otsuka S, Ellenberg J, Sali A.   +5 more
europepmc   +3 more sources