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Nuclear pore complex biogenesis
Current Opinion in Cell Biology, 2009 Nuclear pore complexes (NPCs) are the sole mediators of transport between the nucleus and the cytoplasm. NPCs have a life cycle: they assemble, disassemble, turnover, and age. The molecular mechanisms governing these different vital steps are beginning to emerge, suggesting key roles for the core structural scaffold of the NPC and auxiliary factors in ...
Javier, Fernandez-Martinez +1 more
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The nuclear pore complex prevents sister chromatid recombination during replicative senescence
Nature Communications, 2020 The Nuclear Pore Complex (NPC) has emerged as an important hub for processing various types of DNA damage. Here, we uncover that fusing a DNA binding domain to the NPC basket protein Nup1 reduces telomere relocalization to nuclear pores early after ...
Paula Aguilera +6 more
semanticscholar +1 more source
eLife, 2019 Nuclear entry of HIV-1 replication complexes through intact nuclear pore complexes is critical for successful infection. The host protein cleavage-and-polyadenylation-specificity-factor-6 (CPSF6) has been implicated in different stages of early HIV-1 ...
D. Bejarano +9 more
semanticscholar +1 more source
Nature Communications, 2021 The involvement of nuclear pore proteins in cellular mechanosensing and metastasis is unclear. Here the authors identify that nuclear pore protein NUP210 promotes metastasis through the interaction with mechanotransducer LINC complex protein and ...
Ruhul Amin +17 more
doaj +1 more source
Cells, 2023 The Amoebozoan Dictyostelium discoideum exhibits a semi-closed mitosis in which the nuclear membranes remain intact but become permeabilized to allow tubulin and spindle assembly factors to access the nuclear interior.
Kristina Mitic +3 more
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Permeating the nuclear pore complex [PDF]
Nucleus, 2010 The extensive and multifaceted traffic between nucleus and cytoplasm is handled by a single type of macromolecular assembly called the nuclear pore complex (NPC). While being readily accessible to ions and metabolites, the NPC imposes stringent selectivity on the passage of proteins and RNA, tightly regulating their traffic between the two major ...
Ruti, Kapon +5 more
openaire +2 more sources
The Nuclear Pore Complex and Nuclear Transport [PDF]
Cold Spring Harbor Perspectives in Biology, 2010 Internal membrane bound structures sequester all genetic material in eukaryotic cells. The most prominent of these structures is the nucleus, which is bounded by a double membrane termed the nuclear envelope (NE). Though this NE separates the nucleoplasm and genetic material within the nucleus from the surrounding cytoplasm, it is studded throughout ...
Susan R, Wente, Michael P, Rout
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Generating Membrane Curvature at the Nuclear Pore: A Lipid Point of View
Cells, 2022 In addition to its structural role in enclosing and protecting the genome, the nuclear envelope (NE) forms a highly adaptive communication interface between the cytoplasm and the nuclear interior in eukaryotic cells.
Bas W. A. Peeters +2 more
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Nuclear Pore Complex StructureUnplugged and Dynamic Pores [PDF]
Developmental Cell, 2004 Nuclear pore complexes (NPCs) are large protein assemblies embedded in the nuclear envelope that act as passageways for transport of molecules into and out of the nucleus. Two new studies, one in Nature Cell Biology and one in Science , offer direct evidence that the NPC is a highly dynamic structure.
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Silencing nuclear pore protein Tpr elicits a senescent-like phenotype in cancer cells. [PDF]
PLoS ONE, 2011 Tpr is a large coiled-coil protein located in the nuclear basket of the nuclear pore complex for which many different functions were proposed from yeast to human.Here we show that depletion of Tpr by RNA interference triggers G0-G1 arrest and ultimately ...
Brigitte David-Watine
doaj +1 more source