Results 41 to 50 of about 623,335 (318)

Temporal Changes in Nuclear Envelope Permeability during Semi-Closed Mitosis in Dictyostelium Amoebae

Cells, 2023
The Amoebozoan Dictyostelium discoideum exhibits a semi-closed mitosis in which the nuclear membranes remain intact but become permeabilized to allow tubulin and spindle assembly factors to access the nuclear interior.
Kristina Mitic, Irene Meyer, Ralph Gräf, Marianne Grafe   +3 more
doaj   +1 more source

Exo70-Mediated Recruitment of Nucleoporin Nup62 at the Leading Edge of Migrating Cells is Required for Cell Migration [PDF]

, 2009
Nucleoporin Nup62 localizes at the central channel of the nuclear pore complex and is essential for nucleocytoplasmic transport. Through its FG-repeat domain, Nup62 regulates nuclear pore permeability and binds nuclear transport receptors.
Bayliss, Bayliss, Bernad, Blower, Boyd, Bradford, Brown, Buss, Caswell, Cho, Clarkson, Dawlaty, De Corte, Dultz, Frey, Grindstaff, Gromley, He, Hsu, Inoue, Jeganathan, Joseph, Joseph, Kalverda, Kasper, Kawase, Kawato, Kirsh, Lee, Liu, Loiodice, Macaulay, Matunis, Melcak, Moore, Munson, Nagai, Orjalo, Oztan, Palancade, Palancade, Paschal, Pommereit, Prigent, Rabut, Rittmeyer, Rosse, Sakurai-Yageta, Schrader, Schwarz-Herion, Stewart, Taddei, Tayeb, Terry, Towbin, Van Impe, Wang, Ward, Yeaman, Zimmermann, Zuccolo, Zuo   +61 more
core   +1 more source

Nuclear pore protein NUP210 depletion suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response

Nature Communications, 2021
The involvement of nuclear pore proteins in cellular mechanosensing and metastasis is unclear. Here the authors identify that nuclear pore protein NUP210 promotes metastasis through the interaction with mechanotransducer LINC complex protein and ...
Ruhul Amin, Anjali Shukla, Jacqueline Jufen Zhu, Sohyoung Kim, Ping Wang, Simon Zhongyuan Tian, Andy D. Tran, Debasish Paul, Steven D. Cappell, Sandra Burkett, Huaitian Liu, Maxwell P. Lee, Michael J. Kruhlak, Jennifer E. Dwyer, R. Mark Simpson, Gordon L. Hager, Yijun Ruan, Kent W. Hunter   +17 more
doaj   +1 more source

Construction of nuclear envelope shape by a high-genus vesicle with pore-size constraint [PDF]

Biophys. J. 111, 824-831 (2016), 2016
Nuclear pores have an approximately uniform distribution in the nuclear envelope of most living cells. Hence, the morphology of the nuclear envelope is a spherical stomatocyte with a high genus. We have investigated the morphology of high-genus vesicles under pore-size constraint using dynamically triangulated membrane simulations.
arxiv   +1 more source

Architecture of the nuclear pore complex coat [PDF]

, 2015
The nuclear pore complex (NPC) constitutes the sole gateway for bidirectional nucleocytoplasmic transport. Despite half a century of structural characterization, the architecture of the NPC remains unknown.
Correia, Ana R., Hoelz, André, Kossiakoff, Anthony A., Lin, Daniel H., Lu, Vincent T., Paduch, Marcin, Stuwe, Tobias   +6 more
core   +2 more sources

Generating Membrane Curvature at the Nuclear Pore: A Lipid Point of View

Cells, 2022
In addition to its structural role in enclosing and protecting the genome, the nuclear envelope (NE) forms a highly adaptive communication interface between the cytoplasm and the nuclear interior in eukaryotic cells.
Bas W. A. Peeters, Alexandra C. A. Piët, Maarten Fornerod   +2 more
doaj   +1 more source

An agent-based model for mRNA export through the nuclear pore complex. [PDF]

, 2014
mRNA export from the nucleus is an essential step in the expression of every protein- coding gene in eukaryotes, but many aspects of this process remain poorly understood.
Azimi, Mohammad, Bulat, Evgeny, Mofrad, Mohammad RK, Weis, Karsten   +3 more
core   +2 more sources

Random sub-diffusion and capture of genes by the nuclear pore reduces dynamics and coordinates inter-chromosomal movement

eLife, 2021
Hundreds of genes interact with the yeast nuclear pore complex (NPC), localizing at the nuclear periphery and clustering with co-regulated genes. Dynamic tracking of peripheral genes shows that they cycle on and off the NPC and that interaction with the ...
Michael Chas Sumner, Steven B Torrisi, Donna G Brickner, Jason H Brickner   +3 more
doaj   +1 more source

Structure-function mapping of a heptameric module in the nuclear pore complex. [PDF]

, 2012
The nuclear pore complex (NPC) is a multiprotein assembly that serves as the sole mediator of nucleocytoplasmic exchange in eukaryotic cells. In this paper, we use an integrative approach to determine the structure of an essential component of the yeast ...
Chait, Brian T, Diaz-Avalos, Ruben, Fernandez-Martinez, Javier, Franke, Josef D, Phillips, Jeremy, Rout, Michael P, Sali, Andrej, Sekedat, Matthew D, Stokes, David L, Velazquez-Muriel, Javier, Williams, Rosemary   +10 more
core   +2 more sources

Pore timing:the evolutionary origins of the nucleus and nuclear pore complex [PDF]

, 2019
The name “eukaryote” is derived from Greek, meaning “true kernel”, and describes the domain of organisms whose cells have a nucleus. The nucleus is thus the defining feature of eukaryotes and distinguishes them from prokaryotes (Archaea and Bacteria ...
A Noble, A O'Reilly, A Ori, A Pittis, A Poole, A Spang, A von Appen, C Klinger, D Devos, D Devos, D Lin, E Arakel, E Szathmáry, F Alber, G Dey, G Holzer, H Asakawa, J Cronshaw, J Dacks, J Dacks, J DeGrasse, J Fischer, J Gomez-Cavazos, J Holden, J Kosinski, K Knockenhauer, K Leung, K Tamura, K Zaremba-Niedzwiedzka, M Beck, M Beck, M D'Angelo, M Eibauer, M Faini, M Field, M Field, M Field, M Iwamoto, M Paraan, M Raices, M Robinson, M Rout, M Rout, N Yutin, P Sampathkumar, R Hayama, R Teimer, S Dodonova, S Fath, S Kim, S Mosalaganti, S Obado, S Obado, T Jovanovic-Talisman, T Ritterhoff, T Stuwe, V Sakin, W Martin, W Martin, Y Bykov   +59 more
core   +3 more sources