Results 1 to 10 of about 773,811 (142)

Genotoxic agents promote the nuclear accumulation of annexin A2: role of annexin A2 in mitigating DNA damage [PDF]

, 2012
Annexin A2 is an abundant cellular protein that is mainly localized in the cytoplasm and plasma membrane, however a small population has been found in the nucleus, suggesting a nuclear function for the protein.
A Hofmann, AB Deora, AP Arrigo, B van Loon, B Wolff, BR Henderson, C Johnson, D Bagchi, D Görlich, D Konopka-Postupolska, D Matsuda, DA Eberhard, David M. Waisman, DM Waisman, E Morel, E Venetsanakos, EP Rogakou, G Kassam, GB Clark, HJ Rhee, HK Jindal, I Kovacs, I Rappold, J Liu, JF Caplan, JK Vishwanatha, KL Gould, KM Gorecka, KS Choi, L Zokas, LB Schultz, LJ Mah, M Gama-Carvalho, M Jost, M Jost, MB Kastan, N Crampton, N Johnsson, NR Filipenko, NR Filipenko, NR Filipenko, O Fernandez-Capetillo, PA Madureira, Patricia A. Madureira, Patrick W. K. Lee, R Hill, Richard Hill, S Courtneidge, S Moss, S Réty, SJ Kuerbitz, SM Sacre, Sue Cotterill, T Becker, V Gerke, V Gerke, W Luo, WM Michael, Y Yoneda   +58 more
core   +6 more sources

A monopartite nuclear localization sequence regulates nuclear targeting of the actin binding protein myopodin [PDF]

, 2005
Myopodin is an actin bundling protein that shuttles between nucleus and cytoplasm in response to cell stress or during differentiation. Here, we show that the myopodin sequence (58)KKRRRRARK(66), when tagged to either enhanced green fluorescent protein ...
De Corte, Veerle, De Ganck, Ariane, Geelen, Danny, Gettemans, Jan, Hubert, Thomas, Van Impe, Katrien, Vandekerckhove, Joël   +6 more
core   +1 more source

Herpes simplex virus ICP27 protein directly interacts with the nuclear pore complex through NUP62, inhibiting host nucleocytoplasmic transport pathways [PDF]

, 2012
The herpes simplex virus ICP27 protein is important for the expression and nuclear export of viral mRNAs. Although several binding sites have been mapped along the ICP27 sequence for various RNA and protein partners including the transport receptor TAP ...
Arnold, Aubert, Bachi, Bonifaci, Braun, Bryant, Chen, Chen, Copeland, Cullen, Darshan, Ellison, Ellison, Escudero-Paunetto, Faria, Fischer, Flach, Fontaine-Rodriguez, Fontoura, Fornerod, Fridell, Gerace, Gruffat, Grüter, Gustin, Gustin, Gustin, Han, Hardwicke, Hernandez, Hiriart, Hofemeister, Hutten, Johnson, Kambach, Koffa, Larralde, Lengyel, Lengyel, Li, Lilley, Long, Macaulay, Malik, Malik, McCarthy, Mears, Mears, Mears, Meyer, Michael, Nelson, Park, Pasdeloup, Pasquinelli, Pearson, Pellet, Petersen, Phelan, Piñol-Roma, Pollard, Pritchard, Rice, Rice, Rice, Rice, Rojas, Saavedra, Sandri-Goldin, Satterly, Schmitt, Sekulovich, Siomi, Smith, Soliman, Soliman, Souki, Strambio-De-Castillia, Strässer, Tsuji, Wagstaff, Wente, Zhi, Zhi   +83 more
core   +3 more sources

Proteomic identification of heterogeneous nuclear ribonucleoprotein L as a novel component of SLM/Sam68 nuclear bodies [PDF]

, 2009
Background: Active pre-mRNA splicing occurs co-transcriptionally, and takes place throughout the nucleoplasm of eukaryotic cells. Splicing decisions are controlled by networks of nuclear RNA-binding proteins and their target sequences, sometimes in ...
Bindereif, A., Bourgeois, C.F., Clark, E.L., Dalgliesh, C., Elliott, D.J., Emami, K., Heiner, M., Leung, H.Y., Rajan, P., Robson, C.N., Stevenin, J.   +10 more
core   +7 more sources

Regulation of NF-κB by PML and PML-RARα [PDF]

, 2017
Promyelocytic Leukemia (PML) is a nuclear protein that forms sub-nuclear structures termed nuclear bodies associated with transcriptionally active genomic regions. PML is a tumour suppressor and regulator of cell differentiation.
Ahmed, Abrar, Carmody, Ruaidhri J., Chen, Youhai H., Keeshan, Karen, Lindsay, Andrew J., McCaffrey, Mary W., Mitxitorena, Izaskun, Pandolfi, Pier Paolo, Wan, Xiaochun   +8 more
core   +1 more source

NcPred for accurate nuclear protein prediction using n-mer statistics with various classification algorithms [PDF]

, 2011
Prediction of nuclear proteins is one of the major challenges in genome annotation. A method, NcPred is described, for predicting nuclear proteins with higher accuracy exploiting n-mer statistics with different classification algorithms namely ...
A. Ganesh, A. Garg, A. Pierleoni, A. Reinhardt, B. Alberts, B. Chan, B. Mathews, D. Xie, E. Marcotte, G. Hutchinson, H. Bannai, M. Hall, M. Kumar, O. Emanuelson, W. Jassem   +14 more
core   +3 more sources

Cytochrome oxidase subunit VI of Trypanosoma brucei is imported without a cleaved presequence and is developmentally regulated at both RNA and protein levels [PDF]

, 2001
Mitochondrial respiration in the African trypanosome undergoes dramatic developmental stage regulation. This requires co-ordinated control of components encoded by both the nuclear genome and the kinetoplast, the unusual mitochondrial genome of these ...
Benne R., Beverley S.M., Brun R., Carruthers V.B., Czichos J., Feagin J.E., Folsch H., Hahne K., Hauser R., Hausler T., Hirumi H., Kwast K.E., LeBowitz J.H., Matthews K.R., Osinga K.A., Overath P., Priest J.W., Roditi I., Sherwin T., Smagula C., Sogin M.L., Stuart K., Tasker M., Torri A.F., Tschudi C., Ullu E., Vassella E., Wirtz E., Woods A., Ziegelbauer K.   +29 more
core   +1 more source

Dual Requirement for Yeast hnRNP Nab2p in mRNA poly(A) Tail Length Control and Nuclear Export [PDF]

, 2002
Recent studies of mRNA export factors have provided additional evidence for a mechanistic link between mRNA 3′‐end formation and nuclear export. Here, we identify Nab2p as a nuclear poly(A)‐binding protein required for both poly(A) tail length control ...
Anderson, James T., Dheur, Sonia, Hector, Ronald E., Minvielle‐Sebastia, Lionel, Non, Priscilla J., Nykamp, Keith R., Swanson, Maurice S., Urbinati, Carl R., Wilson, Scott M.   +8 more
core   +3 more sources

In Vivo Localization of Fas-Associated Death Domain Protein in the Nucleus and Cytoplasm of Normal Thyroid and Liver Cells [PDF]

, 2009
FADD (Fas-associated death domain) is the main death receptor adaptor molecule that transmits apoptotic signal. Recently, FADD protein was shown to be expressed both in the cytoplasm and nucleus of in vitro cell lines. In contrast to the cytoplasmic FADD,
Chiocchia, Gilles, Schmitt, Alain, Tourneur, Léa   +2 more
core   +5 more sources

Mitochondrial heat-shock protein hsp60 is essential for assembly of proteins imported into yeast mitochondria [PDF]

, 1989
A nuclear encoded mitochondrial heat-shock protein hsp60 is required for the assembly into oligomeric complexes of proteins imported into the mitochondrial matrix.
Cheng, Ming Yuan, Hallberg, Elisabeth M., Hallberg, Richard L., Hartl, Franz-Ulrich, Horwich, Arthur, Kalousek, Frantisek, Martin, Jörg, Neupert, Walter, Pollock, Robert A.   +8 more
core   +1 more source