Results 21 to 30 of about 8,215,941 (358)

Nanomedicine: A Promising Way to Manage Alzheimer’s Disease

open access: yesFrontiers in Bioengineering and Biotechnology, 2021
Alzheimer’s disease (AD) is a devastating disease of the aging population characterized by the progressive and slow brain decay due to the formation of extracellular plaques in the hippocampus.
Nazeer Hussain Khan   +19 more
doaj   +1 more source

Nanotechnology prospects in brain therapeutics concerning gene-targeting and nose-to-brain administration

open access: yesiScience, 2023
Summary: Neurological diseases are one of the most pressing issues in modern times worldwide. It thus possesses explicit attention from researchers and medical health providers to guard public health against such an expanding threat.
Dong-Dong Wu   +10 more
doaj   +1 more source

Hydrogen Sulfide Attenuates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease by Inhibiting Apoptosis and Promoting Autophagy via Reactive Oxygen Species/Phosphatidylinositol 3-Kinase/AKT/Mammalian Target of Rapamycin Signaling Pathway

open access: yesFrontiers in Pharmacology, 2020
Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease worldwide. Hydrogen sulfide (H2S) is involved in a wide range of physiological and pathological processes.
Dongdong Wu   +16 more
doaj   +1 more source

Regulation and physiological functions of phoenixin

open access: yesFrontiers in Molecular Biosciences, 2022
Phoenixin is a newly discovered neuropeptide generated from small integral membrane protein 20. Phoenixin is a ligand for the G protein-coupled receptor 173 (GPR173) and has been detected in central and peripheral tissues of human, rats, mice, bovine ...
Han Liang   +3 more
doaj   +1 more source

Abstract P-27: The 30S Ribosomal Subunit Assembly Factor Rbfa Plays a Key Role in the Formation of the Central Pseudoknot and in the Correct Docking of Helix 44 of the Decoding Center [PDF]

open access: yesInternational Journal of Biomedicine, 2021
Background: Ribosome biogenesis is a complicated multi-stage process. In the cell, 30S ribosomal subunit assembly is fast and efficient, proceeding with the help of numerous assembly protein factors.
Elena M. Maksimova   +7 more
doaj   +1 more source

NEDDylation promotes nuclear protein aggregation and protects the Ubiquitin Proteasome System upon proteotoxic stress

open access: yesNature Communications, 2018
Spatial management of stress-induced protein aggregation is an integral part of the proteostasis network. Protein modification by the ubiquitin-like molecule NEDD8 increases upon proteotoxic stress and it is characterised by the formation of hybrid NEDD8/
Chantal M. Maghames   +7 more
semanticscholar   +1 more source

Extensive cargo identification reveals distinct biological roles of the 12 importin pathways

open access: yeseLife, 2017
Vast numbers of proteins are transported into and out of the nuclei by approximately 20 species of importin-β family nucleocytoplasmic transport receptors.
Makoto Kimura   +5 more
doaj   +1 more source

Genome-Wide Analysis of Codon Usage Patterns of SARS-CoV-2 Virus Reveals Global Heterogeneity of COVID-19

open access: yesBiomolecules, 2021
The ongoing outbreak of coronavirus disease COVID-19 is significantly implicated by global heterogeneity in the genome organization of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The causative agents of global heterogeneity in the whole
Saadullah Khattak   +11 more
doaj   +1 more source

Nuclear protein import [PDF]

open access: yesCurrent Opinion in Cell Biology, 1997
The defining feature of eukaryotic organisms is the cell nucleus. All nuclear proteins are synthesized in the cytoplasm and need to be imported through the nuclear pore complexes (NPCs) into the nucleus. Import can be directed by various signals, of which the classical nuclear localization signal (NLS) and the M9 import signal are the best ...
openaire   +3 more sources

Hydrogen sulfide-induced post-translational modification as a potential drug target

open access: yesGenes and Diseases, 2023
Hydrogen sulfide (H2S) is one of the three known gas signal transducers, and since its potential physiological role was reported, the literature on H2S has been increasing.
Hao-Jie Chen   +6 more
doaj   +1 more source

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