Regulation of NF-κB by PML and PML-RARα [PDF]
, 2017 Promyelocytic Leukemia (PML) is a nuclear protein that forms sub-nuclear structures termed nuclear bodies associated with transcriptionally active genomic regions. PML is a tumour suppressor and regulator of cell differentiation.
Ahmed, Abrar +8 more
core +1 more source
A cell-specific enhancer that specifies lin-3 expression in the C. elegans anchor cell for vulval development [PDF]
, 2004 During C. elegans vulval development, the anchor cell (AC) in the somatic gonad expresses lin-3, activating the EGF receptor signaling pathway in vulval precursor cells (VPCs) and thereby inducing and patterning VPCs.
Hwang, Byung Joon, Sternberg, Paul W.
core +1 more source
Nuclear Receptors: An Overview [PDF]
, 2006 Peer ...
Aranda, Ana, Pascual, Ángel
openaire +2 more sources
The nuclear receptor LXRα controls the functional specialization of splenic macrophages. [PDF]
, 2013 Macrophages are professional phagocytic cells that orchestrate innate immune responses and have considerable phenotypic diversity at different anatomical locations. However, the mechanisms that control the heterogeneity of tissue macrophages are not well
A-Gonzalez, Noelia +19 more
core +1 more source
Genetic disorders of nuclear receptors [PDF]
Journal of Clinical Investigation, 2017 Following the first isolation of nuclear receptor (NR) genes, genetic disorders caused by NR gene mutations were initially discovered by a candidate gene approach based on their known roles in endocrine pathways and physiologic processes. Subsequently, the identification of disorders has been informed by phenotypes associated with gene disruption in ...
Achermann, John C +3 more
openaire +6 more sources
The Corepressor NCoR1 Antagonizes PGC-1α and Estrogen-Related Receptor α in the Regulation of Skeletal Muscle Function and Oxidative Metabolism [PDF]
, 2012 Skeletal muscle exhibits a high plasticity and accordingly can quickly adapt to different physiological and pathological stimuli by changing its phenotype largely through diverse epigenetic mechanisms.
Pérez-Schindler, Joaquín +9 more
core +5 more sources
Linking Induction and Transrepression of PPARβ/δ with Cellular Function [PDF]
, 2015 The copyrights of all papers published in this journal are retained by the respective authors as per the 'Creative Commons Attribution License' (http://creativecommons.org/licenses/by/3.0/).Peroxisome proliferator activated receptors (PPARs) are ligand ...
MacKenzie, Louise Susan +1 more
core +2 more sources
LMTK3 represses tumor suppressor-like genes through chromatin remodeling in breast cancer [PDF]
, 2015 LMTK3 is an oncogenic receptor tyrosine kinase (RTK) implicated in various types of cancer, including breast, lung, gastric, and colorectal cancer. It is local-ized in different cellular compartments, but its nuclear function has not been investigated so
Aceto +52 more
core +7 more sources
Nuclear hormone receptors in podocytes [PDF]
Cell & Bioscience, 2012 AbstractNuclear receptors are a family of ligand-activated, DNA sequence-specific transcription factors that regulate various aspects of animal development, cell proliferation, differentiation, and homeostasis. The physiological roles of nuclear receptors and their ligands have been intensively studied in cancer and metabolic syndrome.
Simran Khurana +2 more
openaire +4 more sources
Herpes simplex virus ICP27 protein directly interacts with the nuclear pore complex through NUP62, inhibiting host nucleocytoplasmic transport pathways [PDF]
, 2012 The herpes simplex virus ICP27 protein is important for the expression and nuclear export of viral mRNAs. Although several binding sites have been mapped along the ICP27 sequence for various RNA and protein partners including the transport receptor TAP ...
Arnold +83 more
core +3 more sources