Results 21 to 30 of about 5,069,870 (397)

Improved Glucocorticoid Receptor Ligands: Fantastic Beasts, but How to Find Them?

Frontiers in Endocrinology, 2020
Exogenous glucocorticoids are widely used in the clinic for the treatment of inflammatory disorders and hematological cancers. Unfortunately, their use is associated with debilitating side effects, including hyperglycemia, osteoporosis, mood swings, and ...
Laura Van Moortel, Laura Van Moortel, Laura Van Moortel, Kris Gevaert, Kris Gevaert, Karolien De Bosscher, Karolien De Bosscher, Karolien De Bosscher   +7 more
doaj   +1 more source

Circadian rhythm of hepatic cytosolic and nuclear estrogen receptors [PDF]

, 1986
The distribution of estrogen receptor between the cytosolic and nuclear compartments were evaluated in liver of male rats to determine whether a circadian rhythm exists.
Alfredo Dileo, Antonio Francavilla, Aten R. F., Aten R. F., Burton K, David H. Van Thiel, Dickson R. B., Eagon P. K., Eagon P. K., Eagon P. K., Eriksson H. A, Francavilla A., Francesco Guglielmi, Graef V., Kalra P. S., Kneifel R., Lorenzo Polimeno, Lowry O. H., McGuire W. L., Mode A., Norsted G., Patricia K. Eagon, Perrot-Applanat M., Porter L. E., Powell-Jones W., Scatchard G, Stenberg A, Strobl J. S., Thomas E. Starzl, Vallee B. L.   +29 more
core   +1 more source

The nuclear receptor superfamily: A structural perspective

Protein Science, 2018
Nuclear receptors (NRs) are a family of transcription factors that regulate numerous physiological processes such as metabolism, reproduction, inflammation, as well as the circadian rhythm.
E. Weikum, Xu Liu, E. Ortlund
semanticscholar   +1 more source

Regulation of xenobiotic and bile acid metabolism by the nuclear pregnane X receptor

Journal of Lipid Research, 2002
The nuclear pregnane X receptor (PXR; NR1I2) is an integral component of the body's defense mechanism against chemical insult (chemoprotection). PXR is activated by a diverse array of lipophilic chemicals, including xenobiotics and endogenous substances,
Steven A. Kliewer, Timothy M. Willson
doaj   +1 more source

Regulation of NF-κB by PML and PML-RARα [PDF]

, 2017
Promyelocytic Leukemia (PML) is a nuclear protein that forms sub-nuclear structures termed nuclear bodies associated with transcriptionally active genomic regions. PML is a tumour suppressor and regulator of cell differentiation.
Ahmed, Abrar, Carmody, Ruaidhri J., Chen, Youhai H., Keeshan, Karen, Lindsay, Andrew J., McCaffrey, Mary W., Mitxitorena, Izaskun, Pandolfi, Pier Paolo, Wan, Xiaochun   +8 more
core   +1 more source

Nuclear receptor corepressors [PDF]

Nuclear Receptor Signaling, 2003
The ability of NR LBDs to transfer repression function to a heterologous DNA binding domain, and the cross-squelching of repression by untethered LBDs, has suggested that repression is mediated by interactions with putative cellular corepressor proteins.
openaire   +2 more sources

Mechanisms Underlying the Functional Cooperation Between PPARα and GRα to Attenuate Inflammatory Responses

Frontiers in Immunology, 2019
Glucocorticoids (GCs) act via the glucocorticoid receptor (NR3C1, GRα) to combat overshooting responses to infectious stimuli, including lipopolysaccharide (LPS).
Nadia Bougarne, Nadia Bougarne, Nadia Bougarne, Viacheslav Mylka, Viacheslav Mylka, Viacheslav Mylka, Dariusz Ratman, Dariusz Ratman, Dariusz Ratman, Ilse M. Beck, Jonathan Thommis, Jonathan Thommis, Jonathan Thommis, Lode De Cauwer, Lode De Cauwer, Lode De Cauwer, Jan Tavernier, Jan Tavernier, Jan Tavernier, Bart Staels, Claude Libert, Claude Libert, Karolien De Bosscher, Karolien De Bosscher, Karolien De Bosscher   +24 more
doaj   +1 more source

Exposure to Endocrine Disruptors and Nuclear Receptors Gene Expression in Infertile and Fertile Men from Italian Areas with Different Environmental Features [PDF]

, 2015
Internal levels of selected endocrine disruptors (EDs) (i.e., perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), di-2-ethylhexyl-phthalate (DEHP), mono-(2-ethylhexyl)-phthalate (MEHP), and bisphenol A (BPA)) were analyzed in blood/serum of ...
Bergamasco B, Bordi G, Busani L, Caserta D, Ciardo F, Focardi S, Guerranti C, La Rocca C, Mancini FR, Mantovani A, Marci R, Moscarini M, Perra G, Stecca L, Tait S   +14 more
core   +2 more sources

SnapShot: Nuclear Receptors I

Cell, 2010
Clinical: Flutamide and bicalutamide for prostate cancer and alopeciaGlucocorticoid receptorGR/NR3C1 Endogenous: Cortisol (hydrocortisone) Diverse developmental and physiological roles (e.g., antagonism of inflammatory signaling pathways, mediation of the stress response, and gluconeogenesis)Metabolic, cardiovascular, immune and inflammatory, memory↑
McKenna, Neil J., O'Malley, Bert W.
openaire   +3 more sources

Herpes simplex virus ICP27 protein directly interacts with the nuclear pore complex through NUP62, inhibiting host nucleocytoplasmic transport pathways [PDF]

, 2012
The herpes simplex virus ICP27 protein is important for the expression and nuclear export of viral mRNAs. Although several binding sites have been mapped along the ICP27 sequence for various RNA and protein partners including the transport receptor TAP ...
Arnold, Aubert, Bachi, Bonifaci, Braun, Bryant, Chen, Chen, Copeland, Cullen, Darshan, Ellison, Ellison, Escudero-Paunetto, Faria, Fischer, Flach, Fontaine-Rodriguez, Fontoura, Fornerod, Fridell, Gerace, Gruffat, Grüter, Gustin, Gustin, Gustin, Han, Hardwicke, Hernandez, Hiriart, Hofemeister, Hutten, Johnson, Kambach, Koffa, Larralde, Lengyel, Lengyel, Li, Lilley, Long, Macaulay, Malik, Malik, McCarthy, Mears, Mears, Mears, Meyer, Michael, Nelson, Park, Pasdeloup, Pasquinelli, Pearson, Pellet, Petersen, Phelan, Piñol-Roma, Pollard, Pritchard, Rice, Rice, Rice, Rice, Rojas, Saavedra, Sandri-Goldin, Satterly, Schmitt, Sekulovich, Siomi, Smith, Soliman, Soliman, Souki, Strambio-De-Castillia, Strässer, Tsuji, Wagstaff, Wente, Zhi, Zhi   +83 more
core   +3 more sources