Results 21 to 30 of about 734,603 (316)
Nuclear Receptor Signaling Atlas: Opening Access to the Biology of Nuclear Receptor Signaling Pathways. [PDF]
PLoS ONE, 2015 Signaling pathways involving nuclear receptors (NRs), their ligands and coregulators, regulate tissue-specific transcriptomes in diverse processes, including development, metabolism, reproduction, the immune response and neuronal function, as well as in ...
Lauren B Becnel +10 more
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Molecular Therapy: Methods & Clinical Development, 2021 The current methods for detecting circulating tumor cells (CTCs) suffer from several drawbacks. We report a novel method that is based on a chimeric virus probe and can detect CTCs with extremely high specificity and sensitivity. Moreover, it exclusively
Xinping Fu, Lihua Tao, Xiaoliu Zhang
doaj
Data Science Journal, 2017 Public transcriptomic assets in the nuclear receptor (NR) signaling field hold considerable collective potential for exposing underappreciated aspects of NR regulation of gene expression.
Scott A. Ochsner +6 more
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ROR: Nuclear Receptor for Melatonin or Not? [PDF]
Molecules, 2021 Whether the retinoic acid-related orphan receptor (ROR) is a nuclear receptor of melatonin remains controversial. ROR is inextricably linked to melatonin in terms of its expression, function, and mechanism of action. Additionally, studies have illustrated that melatonin functions analogous to ROR ligands, thereby modulating the transcriptional activity
Haozhen Ma +4 more
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Frontiers in Immunology, 2017 Malaria-associated acute respiratory distress syndrome (MA-ARDS) is an often lethal complication of malaria. Currently, no adequate therapy for this syndrome exists. Although glucocorticoids (GCs) have been used to improve clinical outcome of ARDS, their
Karolina A. Zielińska +9 more
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Genetic disorders of nuclear receptors [PDF]
Journal of Clinical Investigation, 2017 Following the first isolation of nuclear receptor (NR) genes, genetic disorders caused by NR gene mutations were initially discovered by a candidate gene approach based on their known roles in endocrine pathways and physiologic processes. Subsequently, the identification of disorders has been informed by phenotypes associated with gene disruption in ...
Achermann, John C +3 more
openaire +6 more sources
Wilson Disease: Update on Pathophysiology and Treatment
Frontiers in Cell and Developmental Biology, 2022 Wilson disease (WD) is a potentially fatal genetic disorder with a broad spectrum of phenotypic presentations. Inactivation of the copper (Cu) transporter ATP7B and Cu overload in tissues, especially in the liver, are established causes of WD.
Som Dev +3 more
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Cell Reports, 2017 Macrophages exert potent effector functions against invading microorganisms but constitute, paradoxically, a preferential niche for many bacterial strains to replicate.
Jonathan Matalonga +23 more
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Nuclear Receptors: An Overview [PDF]
, 2006 Peer ...
Aranda, Ana, Pascual, Ángel
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Active nuclear receptors exhibit highly correlated AF-2 domain motions. [PDF]
PLoS Computational Biology, 2008 Nuclear receptor ligand binding domains (LBDs) convert ligand binding events into changes in gene expression by recruiting transcriptional coregulators to a conserved activation function-2 (AF-2) surface.
Denise G Teotico +5 more
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