Results 1 to 10 of about 339,303 (197)
Nuclear Transport of Yeast Proteasomes. [PDF]
Front Mol Biosci, 2019 Proteasomes are key proteases in regulating protein homeostasis. Their holo-enzymes are composed of 40 different subunits which are arranged in a proteolytic core (CP) flanked by one to two regulatory particles (RP). Proteasomal proteolysis is essential for the degradation of proteins which control time-sensitive processes like cell cycle progression ...
Wendler P, Enenkel C.
europepmc +6 more sources
Cell, 2002 Nuclear Transport Edited by Karsten Weiss New York: Springer Verlag (2001). $104.75Nucleocytoplasmic transport plays a pivotal role in eukaryotic cell function and is relevant to many areas of cell biology. As such, it is somewhat surprising that books on this subject are in short supply. Nuclear Transport, edited by Karsten Weis, is a welcome addition.
Amnon Harel, Douglass J. Forbes
openaire +2 more sources
The Nuclear Pore Complex and Nuclear Transport [PDF]
Cold Spring Harbor Perspectives in Biology, 2010 Internal membrane bound structures sequester all genetic material in eukaryotic cells. The most prominent of these structures is the nucleus, which is bounded by a double membrane termed the nuclear envelope (NE). Though this NE separates the nucleoplasm and genetic material within the nucleus from the surrounding cytoplasm, it is studded throughout ...
Susan R. Wente, Michael P. Rout
openaire +3 more sources
Signaling to Nuclear Transport [PDF]
Developmental Cell, 2008 In a recent issue of Molecular Cell, Yoon et al. provide evidence for the control of nucleocytoplasmic transport by protein kinase signaling pathways through phosphorylation of RanBP3, an accessory factor in the Ran GTPase system. This mechanism may coordinate nucleocytoplasmic transport with other mitogenic effects of these pathways.
openaire +4 more sources
Cell, 2007 I Kap95 Kap60 adaptor for cNLS proteins Yes Importin-b1 Importin-a adaptor for cNLS proteins, Snurportin adaptor for U snRNPsII Kap95 — Yes Importin-b1 SREBP-2, HIV Rev and TAT, Cyclin BKap104 Nab2, Hrp1 (mRNA-binding proteins)t.s. Transportin or Transportin 2PY-NLS-containing proteins, mRNA-binding proteins, histones, ribosomal proteinsKap123 SRP ...
Susan R. Wente +2 more
openaire +2 more sources
Nuclear Transport: Beginning to Gel? [PDF]
Current Biology, 2012 The massive nuclear pore complex mediates nucleocytoplasmic traffic ranging from a single histone to a viral genome. To date, dissecting mechanism has been more an exercise in prediction than biochemical certainty. A recent study combines recombinant proteins with nuclei reconstituted in vitro to test predictions in a startlingly productive manner.
Douglass J. Forbes, Maureen A. Powers
openaire +3 more sources
Nuclear Transport: Run by Ran? [PDF]
The American Journal of Human Genetics, 1998 A distinguishing feature of eukaryotic cells is the compartmentalization of their DNA within the nucleus. The sequestration of the genetic material away from the translational machinery and cytosolic proteins has at least two obvious but important implications: First, there must be a mechanism whereby the separate identities of the nucleus and cytosol ...
Mary Dasso, Robert T. Pu
openaire +3 more sources
Nuclear transport: what a kary-on! [PDF]
Structure, 1999 Compartmentalisation in eukaryotic cells presents special problems in macromolecular transport. Here we use the recently determined X-ray structures of a number of components of the nuclear transport machinery as a framework to review current understanding of this fundamental biological process.
Stephen J. Smerdon, Steven J. Gamblin
openaire +3 more sources
Nuclear transport and transcriptional regulation [PDF]
FEBS Letters, 1999 Studies over the past 10 years have provided major insights into the molecular mechanisms responsible for active transport of macromolecules in and out of the nucleus. Nucleocytoplasmic transport pathways correspond to active and signal‐mediated processes that involve substrates, adaptors and receptors.
Batool Ossareh-Nazari +2 more
openaire +3 more sources
Nuclear Pores: David and Goliath in nuclear transport [PDF]
Current Biology, 1995 AbstractThe small GTP-binding protein Ran has been implicated in protein import into, and mRNA export from, the nucleus. A recently identified ‘giant’ nuclear pore complex protein, Nup358, binds GTP–Ran.
openaire +3 more sources