Nuclear Transport of Yeast Proteasomes [PDF]
Frontiers in Molecular Biosciences, 2019 Proteasomes are key proteases in regulating protein homeostasis. Their holo-enzymes are composed of 40 different subunits which are arranged in a proteolytic core (CP) flanked by one to two regulatory particles (RP).
Petra Wendler, Cordula Enenkel
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Kap-β2/Transportin mediates β-catenin nuclear transport in Wnt signaling [PDF]
eLife, 2022 Wnt signaling is essential for many aspects of embryonic development including the formation of the primary embryonic axis. In addition, excessive Wnt signaling drives multiple diseases including cancer, highlighting its importance for disease ...
Woong Y Hwang +4 more
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Nuclear transport proteins: structure, function and disease relevance [PDF]
Signal Transduction and Targeted Therapy, 2023 Proper subcellular localization is crucial for the functioning of biomacromolecules, including proteins and RNAs. Nuclear transport is a fundamental cellular process that regulates the localization of many macromolecules within the nuclear or cytoplasmic
Yang Yang +5 more
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The Role of Protein Disorder in Nuclear Transport and in Its Subversion by Viruses [PDF]
Cells, 2020 The transport of host proteins into and out of the nucleus is key to host function. However, nuclear transport is restricted by nuclear pores that perforate the nuclear envelope.
Jacinta M. Wubben +2 more
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Gene alterations in the nuclear transport receptor superfamily: A study of head and neck cancer. [PDF]
PLoS ONEIn cancer cells, the nuclear transport system is often disrupted, leading to abnormal localization of nuclear proteins and altered gene expression.
Phuong Thao Nguyen +6 more
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Nuclear transport genes recurrently duplicate by means of RNA intermediates in Drosophila but not in other insects [PDF]
BMC Genomics, 2021 Background The nuclear transport machinery is involved in a well-known male meiotic drive system in Drosophila. Fast gene evolution and gene duplications have been major underlying mechanisms in the evolution of meiotic drive systems, and this might ...
Ayda Mirsalehi +3 more
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Parallel import mechanisms ensure the robust nuclear localization of actin in Drosophila
Frontiers in Molecular Biosciences, 2022 Actin, as an ancient and fundamental protein, participates in various cytoplasmic as well as nuclear functions in eukaryotic cells. Based on its manifold tasks in the nucleus, it is a reasonable assumption that the nuclear presence of actin is essential ...
Péter Borkúti +11 more
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Nuclear Localization Signals for Optimization of Genetically Encoded Tools in Neurons
Frontiers in Cell and Developmental Biology, 2022 Nuclear transport in neurons differs from that in non-neuronal cells. Here we developed a non-opsin optogenetic tool (OT) for the nuclear export of a protein of interest induced by near-infrared (NIR) light.
Maksim M. Karasev +4 more
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eLife, 2021 The nuclear pore complex (NPC) is the sole and selective gateway for nuclear transport, and its dysfunction has been associated with many diseases. The metazoan NPC subcomplex RanBP2, which consists of RanBP2 (Nup358), RanGAP1-SUMO1, and Ubc9, regulates ...
Yujiao He +10 more
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Molecular determinants of large cargo transport into the nucleus
eLife, 2020 Nucleocytoplasmic transport is tightly regulated by the nuclear pore complex (NPC). Among the thousands of molecules that cross the NPC, even very large (>15 nm) cargoes such as pathogens, mRNAs and pre-ribosomes can pass the NPC intact.
Giulia Paci +4 more
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