Results 101 to 110 of about 3,896,158 (300)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Altered GABA(A) Receptor Density and Unaltered Blood Brain Barrier Transport in a Kainate Model of Epilepsy: An In Vivo Study Using C-11-Flumazenil and PET

, 2012
The aim of the present study was to investigate if flumazenil blood-brain barrier transport and binding to the benzodiazepine site on the γ-aminobutyric acid A (GABA(A)) receptor complex is altered in an experimental model of epilepsy and subsequently to
Eriksson, P.A.J., Tagawa, Y., Lammertsma, Adriaan A, Syvänen, Stina,, Windhorst, Albert D, de Lange, Elizabeth C, Labots, M., Windhorst, A.D., Lammertsma, A.A., de Lange, E.C.M., Tagawa, Yoshihiko, Eriksson, Jonas,, Syvanen, S., Voskuyl, R.A., Labots, Maaike, Voskuyl, Rob A   +15 more
core   +1 more source

NDC1 : a crucial membrane-integral nucleoporin of metazoan nuclear pore complexes [PDF]

, 2006
POM121 and gp210 were, until this point, the only known membrane-integral nucleoporins (Nups) of vertebrates and, thus, the only candidate anchors for nuclear pore complexes (NPCs) within the nuclear membrane. In an accompanying study (Stavru et al.), we
Gorlich, D., Hülsmann, Bastian, Anne Spang, Cordes, V., Stavru, F., Hartmann, E., Dirk Görlich, Spang, Anne, Cordes, Volker, C., Volker C. Cordes, Hülsmann, B., Hulsmann, B. B., Bastian B. Hülsmann, Cordes, V. C., Hartmann, Enno, Fabrizia Stavru, Görlich, Dirk, Stavru, Fabrizia, Enno Hartmann, Spang, A., Cordes, Volker,   +20 more
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Nuclear transport: Proliferating pathways [PDF]

Current Biology, 1997
A new pathway of nuclear import has been discovered with the identification of receptors that mediate the nuclear import of shuttling hnRNP proteins in yeast and human cells.
openaire   +2 more sources

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Radioactive Effluents from Nuclear Power Plants Annual Report [PDF]

, 2010
This report describes radioactive effluents from commercial nuclear power plants (NPPs) in the United States. This information was reported by the licensees for radioactive discharges that occurred in 2007. The report provides information relevant to the
U.S. Nuclear Regulatory Commission. Office of Nuclear Reactor Regulation.
core   +1 more source

The nuclear envelope and nuclear pore complexes in neurodegenerative diseases

Frontiers in Cell and Developmental Biology
The nuclear envelope (NE) and nuclear pore complexes (NPCs) play a critical role in maintaining the balance between the nucleus and cytoplasm, which is essential for the structural integrity and gene regulatory functions of eukaryotic cells.
Tingyan Wu, Tingyan Wu, Haochen Xu, Haochen Xu, Lei Cheng, Lei Cheng, Ruoxin Wu, Ruoxin Wu, Fuzheng Guo, Xi Chen, Xi Chen   +10 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source