Kap-β2/Transportin mediates β-catenin nuclear transport in Wnt signaling [PDF]
eLife, 2022 Wnt signaling is essential for many aspects of embryonic development including the formation of the primary embryonic axis. In addition, excessive Wnt signaling drives multiple diseases including cancer, highlighting its importance for disease ...
Woong Y Hwang +4 more
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Nuclear transport proteins: structure, function and disease relevance [PDF]
Signal Transduction and Targeted Therapy, 2023 Proper subcellular localization is crucial for the functioning of biomacromolecules, including proteins and RNAs. Nuclear transport is a fundamental cellular process that regulates the localization of many macromolecules within the nuclear or cytoplasmic
Yang Yang +5 more
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Nuclear transport genes recurrently duplicate by means of RNA intermediates in Drosophila but not in other insects [PDF]
BMC Genomics, 2021 Background The nuclear transport machinery is involved in a well-known male meiotic drive system in Drosophila. Fast gene evolution and gene duplications have been major underlying mechanisms in the evolution of meiotic drive systems, and this might ...
Ayda Mirsalehi +3 more
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Binding of viral nuclear localization signal peptides to importin-α nuclear transport protein. [PDF]
Biophys J, 2023 Delfing BM +7 more
europepmc +3 more sources
Gene alterations in the nuclear transport receptor superfamily: A study of head and neck cancer. [PDF]
PLoS ONEIn cancer cells, the nuclear transport system is often disrupted, leading to abnormal localization of nuclear proteins and altered gene expression.
Phuong Thao Nguyen +6 more
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Nuclear transport maintenance of USP22-AR by Importin-7 promotes breast cancer progression. [PDF]
Cell Death Discov, 2023 Cai GX +6 more
europepmc +3 more sources
YAP inhibits HCMV replication by impairing STING-mediated nuclear transport of the viral genome. [PDF]
PLoS Pathog, 2022 Lee JH +7 more
europepmc +2 more sources
The Ebola Virus Interferon Antagonist VP24 Undergoes Active Nucleocytoplasmic Trafficking
Viruses, 2021 Viral interferon (IFN) antagonist proteins mediate evasion of IFN-mediated innate immunity and are often multifunctional, with distinct roles in viral replication.
Angela R. Harrison +3 more
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The Nuclear Transport Protein Importin-5: A Promising Target in Oncology and Virology
CHIMIA, 2021 Cellular homeostasis importantly relies on the correct nucleoplasmic distribution of a large number of RNA molecules and proteins, which are shuttled by specialized transport receptors.
Rémi Patouret
doaj +1 more source
Nuclear Transporter IPO13 Is Central to Efficient Neuronal Differentiation
Cells, 2022 Molecular transport between the nucleus and cytoplasm of the cell is mediated by the importin superfamily of transport receptors, of which the bidirectional transporter Importin 13 (IPO13) is a unique member, with a critical role in early embryonic ...
Katarzyna A. Gajewska +2 more
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