Results 261 to 270 of about 456,044 (305)
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New Perspectives on Nuclear Transport
Annual Review of Genetics, 2001▪ Abstract A central aspect of cellular function is the proper regulation of nucleocytoplasmic transport. In recent years, significant progress has been made in identifying and characterizing the essential components of the transport machinery. Despite these advances, some facets of this process are still unclear.
Arash Komeili, Erin K O'Shea
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Current Opinion in Cell Biology, 1994
A striking property of nuclear pore complexes is their ability to mediate bi-directional nucleocytoplasmic traffic of proteins and RNAs. In the past year, several new nuclear pore proteins have been identified, but their precise functions remain to be established.
E, Fabre, E C, Hurt
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A striking property of nuclear pore complexes is their ability to mediate bi-directional nucleocytoplasmic traffic of proteins and RNAs. In the past year, several new nuclear pore proteins have been identified, but their precise functions remain to be established.
E, Fabre, E C, Hurt
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Role of karyopherin nuclear transport receptors in nuclear transport by nuclear trafficking peptide
Experimental Cell Research, 2021Nuclear trafficking peptide (NTP), a cell-penetrating peptide (CPP) composed of 10 amino acids (aa) (RIFIHFRIGC), has potent nuclear trafficking activity. Recently, we established a protein-based cell engineering system by using NTP, but it remained elusive how NTP functions as a CPP with nuclear orientation.
Yoichi, Teratake +2 more
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Nuclear transport and transcription
Current Opinion in Cell Biology, 2000The compartmentalization of DNA in the nucleus of eukaryotic cells establishes a connection between the nuclear transport machinery and the transcriptional apparatus. General transcription factors, as well as specific transcriptional activators and repressors, such as p53 and NF-AT, need to be imported into the nucleus following their translation.
A, Komeili, E K, O'Shea
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Journal of Cell Science, 1989
ABSTRACT In this paper, progress towards the goal of understanding communication between the nucleus and cytoplasm using an in vitro system is reviewed. To probe the mechanism of nuclear targeting, we developed an in vitro transport system and have begun to dissect the highly selective process of nuclear transport.
D R, Finlay +4 more
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ABSTRACT In this paper, progress towards the goal of understanding communication between the nucleus and cytoplasm using an in vitro system is reviewed. To probe the mechanism of nuclear targeting, we developed an in vitro transport system and have begun to dissect the highly selective process of nuclear transport.
D R, Finlay +4 more
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Cellular and Molecular Life Sciences, 2001
The term nuclear transport, refers to the movement of a large variety of macromolecules both into and out of the nucleus. Transport must be extremely selective, yet also very efficient. A single type of channel, the nuclear pore complex, mediates all movement across the nuclear envelope.
B B, Quimby, A H, Corbett
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The term nuclear transport, refers to the movement of a large variety of macromolecules both into and out of the nucleus. Transport must be extremely selective, yet also very efficient. A single type of channel, the nuclear pore complex, mediates all movement across the nuclear envelope.
B B, Quimby, A H, Corbett
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Inhibitors of nuclear transport
Current Opinion in Cell Biology, 2019Central to eukaryotic cell function, transport into and out of the nucleus is largely mediated by members of the Importin (IMP) superfamily of transporters of α- and β-types. The first inhibitor of nuclear transport, leptomycin B (LMB), was shown to be a specific inhibitor of the IMPβ homologue Exportin 1 (EXP1) almost 20 years ago, but it has only ...
David A, Jans +2 more
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2002
The regulated traffic of cargoes between nucleus and cytoplasm is now thought rather to be the rule than the exception in nuclear transport. The biological importance of regulated nuclear transport is intuitively suggestive. A fast transcriptional response may be produced by rapid nuclear import of a transcription factor.
Schüller, Christoph, Ruis, Helmut
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The regulated traffic of cargoes between nucleus and cytoplasm is now thought rather to be the rule than the exception in nuclear transport. The biological importance of regulated nuclear transport is intuitively suggestive. A fast transcriptional response may be produced by rapid nuclear import of a transcription factor.
Schüller, Christoph, Ruis, Helmut
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Nuclear transport and nuclear pores in yeast
Antonie van Leeuwenhoek, 1992The central features of nuclear import have been conserved during evolution. In yeast the nuclear accumulation of proteins follows the same selective and active transport mechanisms known from higher eukaryotes. Yeast nuclear proteins contain nuclear localization sequences (NLS) which are presumably recognized by receptors in the cytoplasm and the ...
U, Nehrbass, E C, Hurt
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2002
Publisher Summary This chapter discusses the process of nuclear protein transport. Work on the mechanism of nuclear transport has led to a fairly detailed understanding of how proteins are targeted for import or export. This work has changed the way in which researchers need to think about potential transport mechanisms for their own protein of ...
Marc, Damelin +2 more
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Publisher Summary This chapter discusses the process of nuclear protein transport. Work on the mechanism of nuclear transport has led to a fairly detailed understanding of how proteins are targeted for import or export. This work has changed the way in which researchers need to think about potential transport mechanisms for their own protein of ...
Marc, Damelin +2 more
openaire +2 more sources