Results 271 to 280 of about 456,044 (305)

In or out? Regulating nuclear transport

Current Opinion in Cell Biology, 1999
The compartmentalization of proteins within the nucleus or cytoplasm of a eukaryotic cell offers opportunity for regulation of cell cycle progression and signalling pathways. Nuclear localization of proteins is determined by their ability to interact with specific nuclear import and export factors.
J K, Hood, P A, Silver
openaire   +2 more sources

Mechanisms of nuclear transport and interventions

Advanced Drug Delivery Reviews, 2003
One of the more overlooked aspects of drug action and delivery is the exploitation of nucleocytoplasmic shuttling. Eukaryotic cells regulate many biological processes by the compartmentation of specific proteins into designated areas. Drugs that have a direct effect on a single protein must be able to localize to the same site as the protein and ...
Joshua Z, Gasiorowski, David A, Dean
openaire   +2 more sources

Nuclear Protein Transport Pathways

Nephron Experimental Nephrology, 1999
Nuclear proteins like transcription factors and ribosomal proteins are synthesized in the cytoplasm and have to be transported into the nucleus to fulfill their functions. The transport of proteins >20–60 kD through the nuclear pore complex (NPC) into the nucleus is an active, energy-requiring process.
M, Köhler, H, Haller, E, Hartmann
openaire   +2 more sources

Nuclear Transport: Target for Therapy

Clinical Pharmacology & Therapeutics, 2007
Drugs directed at plasma membrane receptors target environment-cell interactions and are the mainstay of clinical pharmacology. Decoding mechanisms that govern intracellular signaling has recently opened new therapeutic avenues for interventions at cytosol-organellar interfaces.
R S, Faustino, T J, Nelson, A, Terzic, C, Perez-Terzic   +3 more
openaire   +2 more sources

Nuclear actin and transport of RNA

Cell Biology International Reports, 1987
The role of nuclear actin filaments in the RNA transport was investigated. Mouse lymphoma cells, L5178Y, were labeled for 20 min with 3H-uridine, and the isolated nuclei were incubated in a medium consisting of 0.25 M sucrose, 10 mM Tris-HCl (pH 7.5), 2 mM CaCl2, 1 mM ATP and 1mM PMSF.
H, Ueyama, H, Nakayasu, K, Ueda
openaire   +2 more sources

Quantitative models of nuclear transport

Current Opinion in Cell Biology, 2005
Nuclear pore complexes mediate the rapid trafficking of target macromolecules between the nucleus and the cytoplasm but exclude non-targets. Mathematical modeling helps to define the physical properties of a transport medium that can selectively enhance the permeation of some molecules but block others.
Becskei, Attila, Mattaj, Iain W.
openaire   +3 more sources

Nuclear transport kinetics in microarrays of nuclear envelope patches

Journal of Structural Biology, 2002
Optical Single Transporter Recording (OSTR) is a technique for analyzing membrane transport kinetics at high sensitivity, selectivity, and spatial resolution. Cellular membranes are firmly attached to microarrays of small test compartments (TCs) with diameters between approximately 0.1 and 100 microm and depths between approximately 10 and 100 microm ...
Reiner, Peters, Elias, Coutavas, Jan Peter, Siebrasse   +2 more
openaire   +2 more sources

Role of the Nuclear Transport Factor p10 in Nuclear Import

Science, 1996
The nuclear import factor p10 was cloned from Saccharomyces cerevisiae and found to be essential. The protein p10 can bind directly to several peptide repeat-containing nucleoporins. It also binds to the guanosine triphosphatase (GTPase) Ran in its guanosine diphosphate (GDP)-bound form and to karyopherin β ...
U, Nehrbass, G, Blobel
openaire   +2 more sources

Thermal Stress and Nuclear Transport

Nuclear transport is the basis for the biological reaction of eukaryotic cells, as it is essential to coordinate nuclear and cytoplasmic events separated by nuclear envelope. Although we currently understand the basic molecular mechanisms of nuclear transport in detail, many unexplored areas remain.
Shingo, Kose, Yutaka, Ogawa, Naoko, Imamoto   +2 more
openaire   +2 more sources

The nuclear pore complex, nuclear transport, and apoptosis.

Canadian journal of physiology and pharmacology, 2006
The nuclear pore complex (NPC) is the sole gateway between the nucleus and the cytoplasm of interphase eukaryotic cells, and it mediates all trafficking between these 2 cellular compartments. As such, the NPC and nuclear transport play central roles in translocating death signals from the cell membrane to the nucleus where they initiate biochemical and
openaire   +3 more sources