Results 51 to 60 of about 1,042,939 (323)
Extensive cargo identification reveals distinct biological roles of the 12 importin pathways
eLife, 2017 Vast numbers of proteins are transported into and out of the nuclei by approximately 20 species of importin-β family nucleocytoplasmic transport receptors.
Makoto Kimura +5 more
doaj +1 more source
The Transverse-momentum-dependent Parton Distribution Function and Jet Transport in Medium [PDF]
, 2008 We show that the gauge-invariant transverse-momentum-dependent (TMD) quark distribution function can be expressed as a sum of all higher-twist collinear parton matrix elements in terms of a transport operator.
A. Kovner +11 more
core +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Nuclear quantum transport for barrier problems
, 2004 A method is presented which allows one to introduce collective coordinates self-consistently, in distinction to the Caldeira-Leggett model. It is demonstrated how the partition function Z for the total nuclear system can be calculated to deduce ...
Hofmann, Helmut, Rummel, Christian
core +2 more sources
The Tau of Nuclear-Cytoplasmic Transport [PDF]
Neuron, 2018 Aggregation of microtubule-associated protein tau is the hallmark of tauopathies, including Alzheimer's disease. Eftekharzadeh et al. (2018) demonstrate that pathogenic tau alters nucleocytoplasmic transport by interacting with components of the nuclear pore complex, revealing a perturbation shared by multiple neurodegenerative diseases.
Evan Lester, Roy Parker, Roy Parker
openaire +3 more sources
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Nuclear transport: Proliferating pathways [PDF]
Current Biology, 1997 A new pathway of nuclear import has been discovered with the identification of receptors that mediate the nuclear import of shuttling hnRNP proteins in yeast and human cells.
openaire +3 more sources
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Effects of Spin-Isospin Modes in Transport Simulations
, 1997 In-medium properties derived for nuclear matter in a microscopic pi + nucleon-hole + delta-hole model are incorporated into transport simulations of nuclear collisions by means of a local-density approximation and by utilizing a local medium frame ...
Aichelin +19 more
core +1 more source
FEBS Letters, EarlyView.Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke +2 more
wiley +1 more source