Results 91 to 100 of about 13,747 (162)

FUS-induced neurotoxicity in Drosophila is prevented by downregulating nucleocytoplasmic transport proteins. [PDF]

Hum Mol Genet, 2018
Steyaert J, Scheveneels W, Vanneste J, Van Damme P, Robberecht W, Callaerts P, Bogaert E, Van Den Bosch L.   +7 more
europepmc   +1 more source

The GSK3/SHAGGY‐like OsGSK3 phosphorylates and inhibits phase separation of OsFCA at Ser‐43 and Ser‐45 to regulate brassinosteroid signaling and rice architecture

New Phytologist, Volume 251, Issue 4, Page 1909-1929, August 2026.
A working model for GLYCOGEN SYNTHASE KINASE 3‐mediated phosphorylation of FLOWERING CONTROL LOCUS A in the regulation of brassinosteroid signaling and rice growth and development. Summary Brassinosteroid (BR) signaling plays a critical role in rice (Oryza sativa L.) grain development.
Jiaqi Zhang, Fan Wang, Sijia Zhang, Qian Yu, Qimiao Dong, Jianbo Li, Xianglei Wei, Huaying Du, Ye Shen, Rong Mu, Yanxiao Jia, Jinping Cheng, Hongsheng Zhang, Ji Huang, Xiuying Gao   +14 more
wiley   +1 more source

Physiological regulation of neuronal Wnt activity is essential for TDP-43 localization and function

The EMBO Journal
Nuclear exclusion of the RNA- and DNA-binding protein TDP-43 can induce neurodegeneration in different diseases. Diverse processes have been implicated to influence TDP-43 mislocalization, including disrupted nucleocytoplasmic transport (NCT); however ...
Nan Zhang, Anna Westerhaus, Macey Wilson, Ethan Wang, Loyal Goff, Shanthini Sockanathan   +5 more
doaj   +1 more source

Unfolding Plant Defence: Endoplasmic Reticulum Stress Signalling at the Plant‐Pathogen Interface

Plant Biotechnology Journal, Volume 24, Issue 8, Page 4799-4822, August 2026.
ABSTRACT The endoplasmic reticulum (ER) stress response, a conserved proteostasis network, has emerged as a central hub that reprograms plant immunity during pathogen attack. This review synthesises how plants harness ER‐stress signalling to mount multilayered defences and how pathogens have evolved counterstrategies to subvert these pathways.
Zhe Meng, Shuqin Zheng, Federica Brandizzi, Yiran Liu, Chunlei Li, Congcong Ai, Yujiao Wang, Jiadong Qi, Xiuguo Zhang   +8 more
wiley   +1 more source

C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins. [PDF]

Nat Neurosci, 2016
Zhang YJ, Gendron TF, Grima JC, Sasaguri H, Jansen-West K, Xu YF, Katzman RB, Gass J, Murray ME, Shinohara M, Lin WL, Garrett A, Stankowski JN, Daughrity L, Tong J, Perkerson EA, Yue M, Chew J, Castanedes-Casey M, Kurti A, Wang ZS, Liesinger AM, Baker JD, Jiang J, Lagier-Tourenne C, Edbauer D, Cleveland DW, Rademakers R, Boylan KB, Bu G, Link CD, Dickey CA, Rothstein JD, Dickson DW, Fryer JD, Petrucelli L.   +35 more
europepmc   +1 more source

Long‐Term Salt Exposure Reprograms the Nicotiana tabacum BY‐2 Suspension Proteome and Metabolome Toward Stabilization of the Core Metabolic Pathways, Protein Turnover Machinery Modifications, and Protective Metabolome Adjustments

Plant, Cell &Environment, Volume 49, Issue 8, Page 5849-5865, August 2026.
ABSTRACT In this study, we analyzed a unique Nicotiana tabacum BY‐2 line that was gradually adapted to and subsequently maintained in 190 mM NaCl for over 15 years. Years of continuous high salinity shaped a stable “new homeostasis” in BY‐2 suspension cells. Salt‐adapted cells were smaller and formed tighter clusters. Metabolomics revealed constitutive
Anita Rzadkiewicz, Łukasz Marczak, Aleksander Strugała, Maria Tomys, Ewelina Ratajczak, Tomasz Skrzypczak, Przemysław Wojtaszek, Anna Kasprowicz‐Maluśki, Agnieszka Szuba   +8 more
wiley   +1 more source

Adherens junction protein expression is associated with poor response to neoadjuvant FLOT chemotherapy and pro‐inflammatory tumor microenvironment in esophageal adenocarcinoma

International Journal of Cancer, Volume 159, Issue 2, Page 501-515, 15 July 2026.
What's new? Esophageal adenocarcinoma (EAC) is an aggressive cancer with poor survival and variable response to perioperative chemotherapy. Although histopathological features correlate with outcomes, the relationship specifically between adherens junction (AJ) protein expression and treatment response in EAC remains uncertain.
Bastian Grothey, Heike Löser, Tillmann Bedau, Wolfgang Schröder, Christiane J. Bruns, Thomas Zander, Max Krämer, Reinhard Büttner, Alexander Quaas   +8 more
wiley   +1 more source

TMCO1 is upregulated in breast cancer and regulates the response to pro-apoptotic agents in breast cancer cells

Cell Death Discovery
The release of Ca2+ ions from endoplasmic reticulum calcium stores is a key event in a variety of cellular processes, including gene transcription, migration and proliferation.
Alice H. L. Bong, Mélanie Robitaille, Sichun Lin, Amy McCart-Reed, Michael Milevskiy, Stéphane Angers, Sarah J. Roberts-Thomson, Gregory R. Monteith   +7 more
doaj   +1 more source

Tripartite motif-containing 34 (TRIM34) protein interacts with the nucleocytoplasmic transport machinery and negatively modulates antiviral responses. [PDF]

PLoS Pathog
Vázquez-Utrilla P, Rivero V, DeDiego ML.   +2 more
europepmc   +1 more source

Proteomic Analysis on Human Islets Suggests Nucleocytoplasmic Transport as a Mechanism of PERK Attenuation Effects in Diabetes. [PDF]

Mol Cell Proteomics
Park YS, Yun S, Sim MS, An EJ, Lee J, Ha EH, Jang JY, Kwon W, Han D, Jung HS.   +9 more
europepmc   +1 more source