Results 51 to 60 of about 23,876 (290)

Nucleoporin TPR Affects C2C12 Myogenic Differentiation via Regulation of Myh4 Expression

Cells, 2021
The nuclear pore complex (NPC) has emerged as a hub for the transcriptional regulation of a subset of genes, and this type of regulation plays an important role during differentiation.
Jana Uhlířová, Lenka Šebestová, Karel Fišer, Tomáš Sieger, Jindřiška Fišerová, Pavel Hozák   +5 more
doaj   +1 more source

A novel function for the Caenorhabditis elegans torsin OOC-5 in nucleoporin localization and nuclear import. [PDF]

, 2015
Torsin proteins are AAA+ ATPases that localize to the endoplasmic reticular/nuclear envelope (ER/NE) lumen. A mutation that markedly impairs torsinA function causes the CNS disorder DYT1 dystonia. Abnormalities of NE membranes have been linked to torsinA
Dauer, William T, Hall, David H, Nguyen, Ken CQ, Rose, Lesilee S, VanGompel, Michael JW   +4 more
core   +2 more sources

Bridge-Induced Translocation between NUP145 and TOP2 Yeast Genes Models the Genetic Fusion between the Human Orthologs Associated With Acute Myeloid Leukemia

Frontiers in Oncology, 2017
In mammalian organisms liquid tumors such as acute myeloid leukemia (AML) are related to spontaneous chromosomal translocations ensuing in gene fusions.
Valentina Tosato, Valentina Tosato, Valentina Tosato, Nicole West, Jan Zrimec, Dmitri V. Nikitin, Giannino Del Sal, Roberto Marano, Michael Breitenbach, Carlo V. Bruschi, Carlo V. Bruschi   +10 more
doaj   +1 more source

The Nuclear Pore Complex: Birth, Life, and Death of a Cellular Behemoth

Cells, 2022
Nuclear pore complexes (NPCs) are the only transport channels that cross the nuclear envelope. Constructed from ~500–1000 nucleoporin proteins each, they are among the largest macromolecular assemblies in eukaryotic cells.
Elisa Dultz, Matthias Wojtynek, Ohad Medalia, Evgeny Onischenko   +3 more
doaj   +1 more source

An agent-based model for mRNA export through the nuclear pore complex. [PDF]

, 2014
mRNA export from the nucleus is an essential step in the expression of every protein- coding gene in eukaryotes, but many aspects of this process remain poorly understood.
Azimi, Mohammad, Bulat, Evgeny, Mofrad, Mohammad RK, Weis, Karsten   +3 more
core   +2 more sources

Evolutionarily Conserved Sequence Features Regulate the Formation of the FG Network at the Center of the Nuclear Pore Complex. [PDF]

, 2015
The nuclear pore complex (NPC) is the portal for bidirectional transportation of cargos between the nucleus and the cytoplasm. While most of the structural elements of the NPC, i.e.
Lee, BL, Mofrad, MRK, Peyro, M, Soheilypour, M   +3 more
core   +2 more sources

TORC1 inactivation stimulates autophagy of nucleoporin and nuclear pore complexes

Journal of Cell Biology, 2020
Autophagy selectively degrades a wide range of cellular components to regulate cellular functions or maintain cellular homeostasis. Tomioka et al. reveal that the nuclear pore complex and nucleoporins are degraded by selective autophagy upon inactivation
Yui Tomioka, T. Kotani, Hiromi Kirisako, Y. Oikawa, Y. Kimura, H. Hirano, Y. Ohsumi, H. Nakatogawa   +7 more
semanticscholar   +1 more source

Nuclear pore complex-mediated modulation of TCR signaling is required for naïve CD4+ T cell homeostasis. [PDF]

, 2018
Nuclear pore complexes (NPCs) are channels connecting the nucleus with the cytoplasm. We report that loss of the tissue-specific NPC component Nup210 causes a severe deficit of naïve CD4+ T cells.
Borlido, Joana, Bradley, Linda M, Carrette, Florent, D'Angelo, Maximiliano A, Raices, Marcela, Sakuma, Stephen, Tinoco, Roberto   +6 more
core   +1 more source

Functional interactions between nucleoporins and chromatin [PDF]

Current Opinion in Cell Biology, 2011
As the gatekeepers of the eukaryotic cell nucleus, nuclear pore complexes (NPCs) mediate all molecular trafficking between the nucleoplasm and the cytoplasm. In recent years, transport-independent functions of NPC components, nucleoporins, have been identified including roles in chromatin organization and gene regulation. Here, we summarize our current
Yun, Liang, Martin W, Hetzer
openaire   +2 more sources

Exo70-Mediated Recruitment of Nucleoporin Nup62 at the Leading Edge of Migrating Cells is Required for Cell Migration [PDF]

, 2009
Nucleoporin Nup62 localizes at the central channel of the nuclear pore complex and is essential for nucleocytoplasmic transport. Through its FG-repeat domain, Nup62 regulates nuclear pore permeability and binds nuclear transport receptors.
Bayliss, Bayliss, Bernad, Blower, Boyd, Bradford, Brown, Buss, Caswell, Cho, Clarkson, Dawlaty, De Corte, Dultz, Frey, Grindstaff, Gromley, He, Hsu, Inoue, Jeganathan, Joseph, Joseph, Kalverda, Kasper, Kawase, Kawato, Kirsh, Lee, Liu, Loiodice, Macaulay, Matunis, Melcak, Moore, Munson, Nagai, Orjalo, Oztan, Palancade, Palancade, Paschal, Pommereit, Prigent, Rabut, Rittmeyer, Rosse, Sakurai-Yageta, Schrader, Schwarz-Herion, Stewart, Taddei, Tayeb, Terry, Towbin, Van Impe, Wang, Ward, Yeaman, Zimmermann, Zuccolo, Zuo   +61 more
core   +1 more source