Results 51 to 60 of about 8,158 (226)
eLife, 2022 The nuclear envelope (NE) assembles and grows from bilayer lipids produced at the endoplasmic reticulum (ER). How ER membrane incorporation coordinates with assembly of nuclear pore complexes (NPCs) to generate a functional NE is not well understood ...
Michael Sean Mauro +6 more
doaj +1 more source
The human nucleoporin Tpr protects cells from RNA-mediated replication stress
Nature Communications, 2021 Tpr nucleoporin is known to be essential for nuclear transport and mitosis processes. Here the authors explore the link between Tpr and genome instability providing insights into the role of Tpr in safeguarding cells from RNA-mediated replication stress.
Martin Kosar +21 more
doaj +1 more source
Case report: Compound heterozygous NUP85 variants cause autosomal recessive primary microcephaly
Frontiers in Neurology, 2023 Nucleoporin (NUP) 85 is a member of the Y-complex of nuclear pore complex (NPC) that is key for nucleocytoplasmic transport function, regulation of mitosis, transcription, and chromatin organization.
Ethiraj Ravindran +11 more
doaj +1 more source
Nucleus, 2012 Transcriptional regulation is a complex process that requires the integrated action of many multi-protein complexes. The way in which a living cell coordinates the action of these complexes in time and space is still poorly understood. Recent work has shown that nuclear pores, well known for their role in 3' processing and export of transcripts, also ...
Sarma, Nayan J, Willis, Kristine
openaire +4 more sources
Nuclear Import of Hepatitis B Virus Capsids and Genome
Viruses, 2017 Hepatitis B virus (HBV) is an enveloped pararetrovirus with a DNA genome, which is found in an up to 36 nm-measuring capsid. Replication of the genome occurs via an RNA intermediate, which is synthesized in the nucleus.
Lara Gallucci, Michael Kann
doaj +1 more source
The nucleoporin Nup88 is interacting with nuclear lamin A
Molecular Biology of the Cell, 2011 Nuclear pore complexes (NPCs) are embedded in the nuclear envelope (NE) and mediate bidirectional nucleocytoplasmic transport. Their spatial distribution in the NE is organized by the nuclear lamina, a meshwork of nuclear intermediate filament proteins. Major constituents of the nuclear lamina are A- and B-type lamins.
Ulrike Kutay +5 more
openaire +5 more sources
eLife, 2015 Nuclear pore complexes (NPCs) conduct massive transport mediated by shuttling nuclear transport receptors (NTRs), while keeping nuclear and cytoplasmic contents separated.
Hermann Broder Schmidt, Dirk Görlich
doaj +1 more source
LIMK1 as a Novel Kinase of β‐Catenin Promotes Esophageal Cancer Metastasis by Cooperating With CDK5
Advanced Science, EarlyView.Li et al. innovatively map the kinase‐substrate network in esophageal cancer metastasis. Their study demonstrates that LIM domain kinase 1 (LIMK1) and Cyclin‐dependent kinase 5 (CDK5) synergistically increase the phosphorylation of β‐catenin, thereby activating the Wnt/β‐catenin signaling pathway to promote esophageal cancer metastasis.
Shu‐Jun Li +27 more
wiley +1 more source
Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2
eLife, 2018 HIV-1 accesses the nuclear DNA of interphase cells via a poorly defined process involving functional interactions between the capsid protein (CA) and nucleoporins (Nups).
Melissa Kane +6 more
doaj +1 more source
NUP214 (nucleoporin 214kDa) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on NUP214 (nucleoporin 214kDa), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire +2 more sources