Results 161 to 170 of about 141,257 (371)

Genome-wide mapping and cryo-EM structural analyses of the overlapping tri-nucleosome composed of hexasome-hexasome-octasome moieties

Communications Biology
The nucleosome is a fundamental unit of chromatin in which about 150 base pairs of DNA are wrapped around a histone octamer. The overlapping di-nucleosome has been proposed as a product of chromatin remodeling around the transcription start site, and ...
Masahiro Nishimura, Takeru Fujii, Hiroki Tanaka, Kazumitsu Maehara, Ken Morishima, Masahiro Shimizu, Yuki Kobayashi, Kayo Nozawa, Yoshimasa Takizawa, Masaaki Sugiyama, Yasuyuki Ohkawa, Hitoshi Kurumizaka   +11 more
doaj   +1 more source

MNase titration reveals differences between nucleosome occupancy and chromatin accessibility

Nature Communications, 2016
Chromatin accessibility plays a fundamental role in gene regulation. Nucleosome placement, usually measured by quantifying protection of DNA from enzymatic digestion, can regulate accessibility. We introduce a metric that uses micrococcal nuclease (MNase)
J. Mieczkowski, A. Cook, S. Bowman, Britta Mueller, B. Alver, Sharmistha Kundu, A. Deaton, Jennifer A Urban, E. Larschan, P. Park, R. Kingston, M. Tolstorukov   +11 more
semanticscholar   +1 more source

3D‐Printed Device for Efficient Packing of Semisolid Samples in 3.2‐mm Rotors Used in Cryoprobe Systems

Magnetic Resonance in Chemistry, EarlyView.
The packing tools facilitate the handling of semisolid samples by enabling reproducible centrifugation‐based packing and controlled unloading into 3.2‐mm rotors used in cryogenic probes, thereby optimizing sample preparation for solid‐state NMR. ABSTRACT We present a compact, 3D‐printed device designed to facilitate the efficient packing of semisolid ...
Andrea Gelardo, Gustavo A. Titaux‐Delgado   +1 more
wiley   +1 more source

Nuclease digestion in between and within nucleosomes [PDF]

, 1976
W. Greil, Tibor Igo‐Kemenes, Hans G. Zachau   +2 more
openalex   +1 more source

Key Regulators of Parasite Biology Viewed Through a Post‐Translational Modification Repertoire

PROTEOMICS, EarlyView.
ABSTRACT Parasites are the leading causes of morbidity and mortality in both humans and animals, imposing substantial socioeconomic burdens worldwide. Controlling parasitic diseases has become one of the key issues in achieving “One Health”. Most parasites have sophisticated life cycles exhibiting progressive developmental stages, morphologies, and ...
Naiwen Zhang, Ning Jiang, Qijun Chen
wiley   +1 more source

Creating a bacterium that forms eukaryotic nucleosome core particles

Nature Communications
The nucleosome is one of the hallmarks of eukaryotes, a dynamic platform that supports many critical functions in eukaryotic cells. Here, we engineer the in vivo assembly of the nucleosome core in the model bacterium Escherichia coli.
Xinyun Jing, Niubing Zhang, Xiaojuan Zhou, Ping Chen, Jie Gong, Kaixiang Zhang, Xueting Wu, Wenjuan Cai, Bang-Ce Ye, Pei Hao, Guo-ping Zhao, Sheng Yang, Xuan Li   +12 more
doaj   +1 more source

Stochastic model for nucleosome sliding in the presence of DNA ligands

, 2008
Heat-induced mobility of nucleosomes along DNA is an experimentally well-studied phenomenon. A recent experiment shows that the repositioning is modified in the presence of minor-groove binding DNA ligands.
B. ten Heggeler-Bordier, D. Lacoste, F. Mohammad-Rafiee, G. Meersseman, H. Schiessel, J. Deseigne, L. Mollazadeh-Beidokhti, T. H. Cormen   +7 more
core   +1 more source

The Extremely Low Mechanical Force Generated by Nano‐Pulling Induces Global Changes in the Microtubule Network, Nuclear Morphology, and Chromatin Transcription in Neurons

Small, EarlyView.
Nano‐pulling induces stabilization, reorganization, and reorientation of the microtubule network. The nucleus of stretched cells experiences increased lateral tension, becomes more spherical, and develops surface grooves. At the level of gene expression regulation, changes in nuclear morphology induce global chromatin remodeling, leading to reduced ...
Alessandro Falconieri, Lorenzo Da Palmata, Valentina Cappello, Tiziana Julia Nadjeschda Schmidt, Pietro Folino, Barbara Storti, Ranieri Bizzarri, Vittoria Raffa   +7 more
wiley   +1 more source

Linking numbers and nucleosomes. [PDF]

, 1976
F H Crick
openalex   +1 more source

DNA Spools under Tension

, 2003
DNA-spools, structures in which DNA is wrapped and helically coiled onto itself or onto a protein core are ubiquitous in nature. We develop a general theory describing the non-equilibrium behavior of DNA-spools under linear tension.
C. G. Baumann, E. Evans, E. Evans, H. Schiessel, H. Yin, I. M. Kulić, J. F. Marko, K. B. Thurmond, R. Bruinsma   +8 more
core   +1 more source