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Nucleosome—nucleosome interaction in chromatin
FEBS Letters, 1979 The available data suggest that transcriptional activity of chromatin is connected with its structural changes [ 1,2]. According to the electron microscope evidence, the elementary 100 A chromatin thread can exist in two main states, i.e., in a compact state, which is characterized by tight packing of nucleosomes and in an extended state when the ...
S. B. Svetlikova +2 more
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Circulating Nucleosomes and Nucleosome Modifications as Biomarkers in Cancer [PDF]
Cancers, 2017 Traditionally the stratification of many cancers involves combining tumour and clinicopathological features (e.g., patient age; tumour size, grade, receptor status and location) to inform treatment options and predict recurrence risk and survival. However, current biomarkers often require invasive excision of the tumour for profiling, do not allow ...
Peter McAnena +2 more
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BMC Genomics, 2009 Background The nucleosome is the fundamental unit of eukaryotic genomes. Its positioning plays a central role in diverse cellular processes that rely on access to genomic DNA.
Wang Jiang +6 more
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Science Advances, 2015 Reestablishment of the nucleosome landscape behind the replication fork is fundamental for epigenetic memory during development.
Ramachandran, Srinivas, Henikoff, Steven
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Crystal structures of heterotypic nucleosomes containing histones H2A.Z and H2A [PDF]
Open Biology, 2016 H2A.Z is incorporated into nucleosomes located around transcription start sites and functions as an epigenetic regulator for the transcription of certain genes.
Naoki Horikoshi +3 more
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Nature Communications, 2020 Liquid–liquid phase separation (LLPS) is an important mechanism that helps explain the membraneless compartmentalization of the nucleus. Because chromatin compaction and LLPS are collective phenomena, linking their modulation to the physicochemical ...
Stephen E. Farr +4 more
semanticscholar +1 more source
Cell Discovery, 2021 Substitution of lysine 36 with methionine in histone H3.3 (H3.3K36M) is an oncogenic mutation that inhibits SETD2-mediated histone H3K36 tri-methylation in tumors.
Yingying Liu +9 more
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HP1 reshapes the nucleosome core to promote phase separation of heterochromatin
Nature, 2019 Heterochromatin affects genome function at many levels. It enables heritable gene repression, maintains chromosome integrity and provides mechanical rigidity to the nucleus1,2.
S. Sanulli +8 more
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Dynamic nucleosome landscape elicits a noncanonical GATA2 pioneer model
Nature Communications, 2022 Here the authors provide a multi-omic study of the nucleosome landscape in LNCaP cells and observe nine functional nucleosome states each with characteristic nucleosome footprints.
Tianbao Li +7 more
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Conservation of Nucleosome Positions in Duplicated and Orthologous Gene Pairs
The Scientific World Journal, 2012 Although nucleosome positions tend to be conserved in gene promoters, whether they are conserved in duplicated and orthologous genes is unknown. In order to elucidate how nucleosome positions are conserved between duplicated and orthologous gene pairs, I
Hiromi Nishida
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