Results 21 to 30 of about 156,001 (374)
Structural and biochemical analyses of monoubiquitinated human histones H2B and H4 [PDF]
Open Biology, 2016 Monoubiquitination is a major histone post-translational modification. In humans, the histone H2B K120 and histone H4 K31 residues are monoubiquitinated and may form transcriptionally active chromatin.
Shinichi Machida +4 more
doaj +1 more source
DNA-encoded nucleosome occupancy is associated with transcription levels in the human malaria parasite Plasmodium falciparum. [PDF]
, 2014 BackgroundIn eukaryotic organisms, packaging of DNA into nucleosomes controls gene expression by regulating access of the promoter to transcription factors.
Bunnik, Evelien M +6 more
core +3 more sources
Nucleosome Positioning, Nucleosome Spacing and the Nucleosome Code [PDF]
Journal of Biomolecular Structure and Dynamics, 2010 Nucleosome positioning has been the subject of intense study for many years. The properties of micrococcal nuclease, the enzyme central to these studies, are discussed. The various methods used to determine nucleosome positions in vitro and in vivo are reviewed critically.
openaire +2 more sources
Contributions of histone H3 nucleosome core surface mutations to chromatin structures, silencing and DNA repair. [PDF]
PLoS ONE, 2011 Histone H3 mutations in residues that cluster in a discrete region on the nucleosome surface around lysine 79 of H3 affect H3-K79 methylation, impair transcriptional silencing in subtelomeric chromatin, and reveal distinct contributions of histone H3 to ...
Michel Fink +2 more
doaj +1 more source
Structural basis of nucleosome-dependent cGAS inhibition
Science, 2020 Saving a host cell from itself A fundamental mammalian defense mechanism against pathogens and damaged cellular DNA is to recognize DNA fragments in the cytosol and trigger an inflammatory response.
J. Boyer +6 more
semanticscholar +1 more source
Nucleosome—nucleosome interaction in chromatin
FEBS Letters, 1979 The available data suggest that transcriptional activity of chromatin is connected with its structural changes [ 1,2]. According to the electron microscope evidence, the elementary 100 A chromatin thread can exist in two main states, i.e., in a compact state, which is characterized by tight packing of nucleosomes and in an extended state when the ...
Pospelov, V.A. +2 more
openaire +2 more sources
BMC Genomics, 2009 Background The nucleosome is the fundamental unit of eukaryotic genomes. Its positioning plays a central role in diverse cellular processes that rely on access to genomic DNA.
Wang Jiang +6 more
doaj +1 more source
PuFFIN--a parameter-free method to build nucleosome maps from paired-end reads. [PDF]
, 2014 BackgroundWe introduce a novel method, called PuFFIN, that takes advantage of paired-end short reads to build genome-wide nucleosome maps with larger numbers of detected nucleosomes and higher accuracy than existing tools. In contrast to other approaches
Bunnik, Evelien M +3 more
core +4 more sources
Cell Discovery, 2021 Substitution of lysine 36 with methionine in histone H3.3 (H3.3K36M) is an oncogenic mutation that inhibits SETD2-mediated histone H3K36 tri-methylation in tumors.
Yingying Liu +9 more
doaj +1 more source
Dissecting OCT4 defines the role of nucleosome binding in pluripotency
Nature Cell Biology, 2021 Pioneer transcription factors such as OCT4 can target silent genes embedded in nucleosome-dense regions. How nucleosome interaction enables transcription factors to target chromatin and determine cell identity remains elusive.
G. Roberts +7 more
semanticscholar +1 more source