Results 31 to 40 of about 64,059 (299)
Thermodynamic modeling of genome-wide nucleosome depleted regions in yeast.
PLoS Computational Biology, 2021 Nucleosome positioning in the genome is essential for the regulation of many nuclear processes. We currently have limited capability to predict nucleosome positioning in vivo, especially the locations and sizes of nucleosome depleted regions (NDRs). Here,
Hungyo Kharerin, Lu Bai
doaj +1 more source
Quantitative test of the barrier nucleosome model for statistical positioning of nucleosomes up- and downstream of transcription start sites [PDF]
PLoS Comp. Biol. 6, e1000891 (2010), 2010 The positions of nucleosomes in eukaryotic genomes determine which parts of the DNA sequence are readily accessible for regulatory proteins and which are not. Genome-wide maps of nucleosome positions have revealed a salient pattern around transcription start sites, involving a nucleosome-free region (NFR) flanked by a pronounced periodic pattern in the
arxiv +1 more source
Mediator–Nucleosome Interaction [PDF]
Molecular Cell, 2000 Mediator, a multiprotein complex involved in the regulation of RNA polymerase II transcription, binds to nucleosomes and acetylates histones. Three lines of evidence identify the Nut1 subunit of Mediator as responsible for the histone acetyltransferase (HAT) activity. An "in-gel" HAT assay reveals a single band of the appropriate size.
Lawrence C. Myers +4 more
openaire +3 more sources
Ion counting demonstrates a high electrostatic field generated by the nucleosome
eLife, 2019 In eukaryotes, a first step towards the nuclear DNA compaction process is the formation of a nucleosome, which is comprised of negatively charged DNA wrapped around a positively charged histone protein octamer.
Magdalena Gebala +3 more
doaj +1 more source
Linking stochastic fluctuations in chromatin structure and gene expression. [PDF]
PLoS Biology, 2013 The number of mRNA and protein molecules expressed from a single gene molecule fluctuates over time. These fluctuations have been attributed, in part, to the random transitioning of promoters between transcriptionally active and inactive states, causing ...
Christopher R Brown +4 more
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Chromatin—a global buffer for eukaryotic gene control
AIMS Biophysics, 2015 Most of eukaryotic DNA is embedded into nucleosome arrays formed by DNA wrapped around a core histone octamer. Nucleosome is a fundamental repeating unit of chromatin guarding access to the genetic information.
Yuri M. Moshkin
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ISRN Molecular Biology, 2012 Nucleosome positioning is not only related to genomic DNA compaction but also to other biological functions. After the chromatin is digested by micrococcal nuclease, nucleosomal (nucleosome-bound) DNA fragments can be sequenced and mapped on the genomic DNA sequence.
openaire +2 more sources
BMC Genomics, 2010 Background Recently, a number of high-resolution genome-wide maps of nucleosome locations in S. cerevisiae have been derived experimentally. However, nucleosome positions are determined in vivo by the combined effects of numerous factors.
Deng Yangyang +6 more
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Conditions for positioning of nucleosomes on DNA [PDF]
Phys. Rev. E 92, 022704 (2015), 2015 Positioning of nucleosomes along eukaryotic genomes plays an important role in their organization and regulation. There are many different factors affecting the location of nucleosomes. Some can be viewed as preferential binding of a single nucleosome to different locations along the DNA and some as interactions between neighboring nucleosomes. In this
arxiv +1 more source
Electrophoresis of Positioned Nucleosomes [PDF]
Biophysical Journal, 2007 to appear in Biophys. J.
Castelnovo, Martin, Grauwin, Sébastian
openaire +5 more sources