Results 31 to 40 of about 156,001 (374)
High nucleosome occupancy is encoded at human regulatory sequences. [PDF]
PLoS ONE, 2010 Active eukaryotic regulatory sites are characterized by open chromatin, and yeast promoters and transcription factor binding sites (TFBSs) typically have low intrinsic nucleosome occupancy. Here, we show that in contrast to yeast, DNA at human promoters,
Desiree Tillo +9 more
doaj +1 more source
HP1 reshapes the nucleosome core to promote phase separation of heterochromatin
Nature, 2019 Heterochromatin affects genome function at many levels. It enables heritable gene repression, maintains chromosome integrity and provides mechanical rigidity to the nucleus1,2.
S. Sanulli +8 more
semanticscholar +1 more source
Manipulating chromatin architecture in C. elegans
Epigenetics & Chromatin, 2022 Background Nucleosome-mediated chromatin compaction has a direct effect on the accessibility of trans-acting activators and repressors to DNA targets and serves as a primary regulatory agent of genetic expression. Understanding the nature and dynamics of
John L. Carter +3 more
doaj +1 more source
Nature Communications, 2020 Liquid–liquid phase separation (LLPS) is an important mechanism that helps explain the membraneless compartmentalization of the nucleus. Because chromatin compaction and LLPS are collective phenomena, linking their modulation to the physicochemical ...
Stephen E. Farr +4 more
semanticscholar +1 more source
BMC Evolutionary Biology, 2011 Background Divergence of transcription factor binding sites is considered to be an important source of regulatory evolution. The associations between transcription factor binding sites and phenotypic diversity have been investigated in many model ...
Chu Wen-Yi +4 more
doaj +1 more source
Genome-scale identification of nucleosome organization by using 1000 porcine oocytes at different developmental stages. [PDF]
PLoS ONE, 2017 The nucleosome is the basic structural unit of chromosomes, and its occupancy and distribution in promoters are crucial for the regulation of gene expression.
Chenyu Tao +5 more
doaj +1 more source
The size of the nucleosome [PDF]
, 2011 The structural origin of the size of the 11 nm nucleosomal disc is addressed. On the nanometer length-scale the organization of DNA as chromatin in the chromosomes involves a coiling of DNA around the histone core of the nucleosome.
A. Travers +3 more
core +2 more sources
Structural basis of nucleosome transcription mediated by Chd1 and FACT
Nature Structural & Molecular Biology, 2020 Efficient transcription of RNA polymerase II (Pol II) through nucleosomes requires the help of various factors. Here we show biochemically that Pol II transcription through a nucleosome is facilitated by the chromatin remodeler Chd1 and the histone ...
L. Farnung +3 more
semanticscholar +1 more source
Conservation of Nucleosome Positions in Duplicated and Orthologous Gene Pairs
The Scientific World Journal, 2012 Although nucleosome positions tend to be conserved in gene promoters, whether they are conserved in duplicated and orthologous genes is unknown. In order to elucidate how nucleosome positions are conserved between duplicated and orthologous gene pairs, I
Hiromi Nishida
doaj +1 more source
Dynamic nucleosome landscape elicits a noncanonical GATA2 pioneer model
Nature Communications, 2022 Here the authors provide a multi-omic study of the nucleosome landscape in LNCaP cells and observe nine functional nucleosome states each with characteristic nucleosome footprints.
Tianbao Li +7 more
doaj +1 more source