Ubiquitous nucleosome unwrapping in the yeast genome [PDF]
, 2013 Nucleosome core particle is a dynamic structure -- DNA may transiently peel off the histone octamer surface due to thermal fluctuations or the action of chromatin remodeling enzymes.
Chereji, Răzvan V. +1 more
core +2 more sources
Structural basis of nucleosome-dependent cGAS inhibition
Science, 2020 Saving a host cell from itself A fundamental mammalian defense mechanism against pathogens and damaged cellular DNA is to recognize DNA fragments in the cytosol and trigger an inflammatory response.
J. Boyer +6 more
semanticscholar +1 more source
DNA-encoded nucleosome occupancy is associated with transcription levels in the human malaria parasite Plasmodium falciparum. [PDF]
, 2014 BackgroundIn eukaryotic organisms, packaging of DNA into nucleosomes controls gene expression by regulating access of the promoter to transcription factors.
Bunnik, Evelien M +6 more
core +3 more sources
TRF2 controls telomeric nucleosome organization in a cell cycle phase-dependent manner [PDF]
, 2012 Mammalian telomeres stabilize chromosome ends as a result of their assembly into a peculiar form of chromatin comprising a complex of non-histone proteins named shelterin.
Bauwens, Serge +10 more
core +11 more sources
Quantitative test of the barrier nucleosome model for statistical positioning of nucleosomes up- and downstream of transcription start sites [PDF]
, 2010 The positions of nucleosomes in eukaryotic genomes determine which parts of the DNA sequence are readily accessible for regulatory proteins and which are not.
A Flaus +46 more
core +5 more sources
The chromatin remodeller ACF acts as a dimeric motor to space nucleosomes. [PDF]
, 2009 Evenly spaced nucleosomes directly correlate with condensed chromatin and gene silencing. The ATP-dependent chromatin assembly factor (ACF) forms such structures in vitro and is required for silencing in vivo.
Acevedo, Ashley +8 more
core +2 more sources
PuFFIN--a parameter-free method to build nucleosome maps from paired-end reads. [PDF]
, 2014 BackgroundWe introduce a novel method, called PuFFIN, that takes advantage of paired-end short reads to build genome-wide nucleosome maps with larger numbers of detected nucleosomes and higher accuracy than existing tools. In contrast to other approaches
Bunnik, Evelien M +3 more
core +4 more sources
Analysis of nucleosome positioning landscapes enables gene discovery in the human malaria parasite Plasmodium falciparum. [PDF]
, 2015 BackgroundPlasmodium falciparum, the deadliest malaria-causing parasite, has an extremely AT-rich (80.7 %) genome. Because of high AT-content, sequence-based annotation of genes and functional elements remains challenging.
Bunnik, Evelien M +5 more
core +2 more sources
Genome-scale identification of nucleosome organization by using 1000 porcine oocytes at different developmental stages. [PDF]
PLoS ONE, 2017 The nucleosome is the basic structural unit of chromosomes, and its occupancy and distribution in promoters are crucial for the regulation of gene expression.
Chenyu Tao +5 more
doaj +1 more source
Structural basis of nucleosome transcription mediated by Chd1 and FACT
Nature Structural & Molecular Biology, 2020 Efficient transcription of RNA polymerase II (Pol II) through nucleosomes requires the help of various factors. Here we show biochemically that Pol II transcription through a nucleosome is facilitated by the chromatin remodeler Chd1 and the histone ...
L. Farnung +3 more
semanticscholar +1 more source