Results 41 to 50 of about 64,059 (299)
Cell cycle-specified fluctuation of nucleosome occupancy at gene promoters. [PDF]
PLoS Genetics, 2006 The packaging of DNA into nucleosomes influences the accessibility of underlying regulatory information. Nucleosome occupancy and positioning are best characterized in the budding yeast Saccharomyces cerevisiae, albeit in asynchronous cell populations or
Gregory J Hogan +2 more
doaj +1 more source
Organization of fast and slow chromatin revealed by single-nucleosome dynamics [PDF]
, 2019 Understanding chromatin organization and dynamics is important since they crucially affect DNA functions. In this study, we investigate chromatin dynamics by statistically analyzing single-nucleosome movement in living human cells. Bi-modal nature of the mean squared displacement distribution of nucleosomes allows for a natural categorization of the ...
arxiv +1 more source
Nucleosome-coupled expression differences in closely-related species
BMC Genomics, 2011 Background Genome-wide nucleosome occupancy is negatively related to the average level of transcription factor motif binding based on studies in yeast and several other model organisms.
Gebbia Marinella +6 more
doaj +1 more source
Nucleosome free regions in yeast promoters result from competitive binding of transcription factors that interact with chromatin modifiers. [PDF]
PLoS Computational Biology, 2013 Because DNA packaging in nucleosomes modulates its accessibility to transcription factors (TFs), unraveling the causal determinants of nucleosome positioning is of great importance to understanding gene regulation.
Evgeniy A Ozonov, Erik van Nimwegen
doaj +1 more source
High-throughput sequencing reveals a simple model of nucleosome energetics [PDF]
PNAS vol. 107 no. 49 (2010), 20998-21003, 2010 We use nucleosome maps obtained by high-throughput sequencing to study sequence specificity of intrinsic histone-DNA interactions. In contrast with previous approaches, we employ an analogy between a classical one-dimensional fluid of finite-size particles in an arbitrary external potential and arrays of DNA-bound histone octamers.
arxiv +1 more source
Molecular Genetics &Genomic Medicine, Volume 11, Issue 1, January 2023., 2023 In this report, we described two cases of NEDDFL caused by novel variants (NM_004459.6: c.1133G>A, c.5941delC) in BPTF gene. Both children had short stature and responded to recombinant human growth hormone treatment ‐ the first report of this therapy in NEDDFL patients.
Wenyong Wu, Ruimin Chen
wiley +1 more source
NAP1-assisted nucleosome assembly on DNA measured in real time by single-molecule magnetic tweezers. [PDF]
PLoS ONE, 2012 While many proteins are involved in the assembly and (re)positioning of nucleosomes, the dynamics of protein-assisted nucleosome formation are not well understood.
Rifka Vlijm +3 more
doaj +1 more source
Ubiquitous nucleosome unwrapping in the yeast genome [PDF]
, 2013 Nucleosome core particle is a dynamic structure -- DNA may transiently peel off the histone octamer surface due to thermal fluctuations or the action of chromatin remodeling enzymes. Partial DNA unwrapping enables easier access of DNA-binding factors to their target sites and thus may provide a dominant pathway for effecting rapid and robust access to ...
arxiv +1 more source
Structural characterization of H3K56Q nucleosomes and nucleosomal arrays [PDF]
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2010 The post-translational modification of histones is a key mechanism for the modulation of DNA accessibility. Acetylated lysine 56 in histone H3 is associated with nucleosome assembly during replication and DNA repair, and is thus likely to predominate in regions of chromatin containing nucleosome-free regions.
Karolin Luger +7 more
openaire +3 more sources
Exploring the Link between Nucleosome Occupancy and DNA Methylation
Frontiers in Genetics, 2018 Near promoters, both nucleosomes and CpG sites form characteristic spatial patterns. Previously, nucleosome depleted regions were observed upstream of transcription start sites and nucleosome occupancy was reported to correlate both with CpG density and ...
Cecilia Lövkvist +2 more
doaj +1 more source