Results 41 to 50 of about 156,001 (374)

Nucleosome Positioning [PDF]

ISRN Molecular Biology, 2012
Nucleosome positioning is not only related to genomic DNA compaction but also to other biological functions. After the chromatin is digested by micrococcal nuclease, nucleosomal (nucleosome-bound) DNA fragments can be sequenced and mapped on the genomic DNA sequence.
openaire   +2 more sources

Ion counting demonstrates a high electrostatic field generated by the nucleosome

eLife, 2019
In eukaryotes, a first step towards the nuclear DNA compaction process is the formation of a nucleosome, which is comprised of negatively charged DNA wrapped around a positively charged histone protein octamer.
Magdalena Gebala, Stephanie L Johnson, Geeta J Narlikar, Dan Herschlag   +3 more
doaj   +1 more source

Crystal structures of heterotypic nucleosomes containing histones H2A.Z and H2A [PDF]

Open Biology, 2016
H2A.Z is incorporated into nucleosomes located around transcription start sites and functions as an epigenetic regulator for the transcription of certain genes.
Naoki Horikoshi, Yasuhiro Arimura, Hiroyuki Taguchi, Hitoshi Kurumizaka   +3 more
doaj   +1 more source

Architecture of the chromatin remodeler RSC and insights into its nucleosome engagement. [PDF]

, 2019
Eukaryotic DNA is packaged into nucleosome arrays, which are repositioned by chromatin remodeling complexes to control DNA accessibility. The Saccharomyces cerevisiae RSC (Remodeling the Structure of Chromatin) complex, a member of the SWI/SNF chromatin ...
Afonine, Afonine, Allen, Angus-Hill, Ashkenazy, Ashkenazy, Asturias, Badis, Buchan, Buchan, Cairns, Cairns, Campsteijn, Chaban, Chambers, Chatterjee, Clapier, Clapier, Côté, Da, Dechassa, Duan, Dutta, Dürr, El-Gebali, Emsley, Erkina, Filippakopoulos, Goddard, Han, Jones, Jones, Kadoch, Kasten, Klein-Brill, Krietenstein, Kuryan, Leschziner, Leschziner, Li, Liu, Lopéz-Blanco, Mashtalir, Morin, Nagai, Nakane, Ng, Patel, Pettersen, Puig, Saha, Sammak, Schorb, Schubert, Sen, Shim, Sievers, Skiniotis, Smith, Suloway, Söding, Tan, Tsunaka, Ungar, Valencia, Wagner, Wang, Wilson, Xia, Yan, Yang, Ye, Yen, Zhang, Zhang, Zhang, Zheng, Zivanov, Zivanov, Zukin   +79 more
core   +3 more sources

The DNA-binding domain of the Chd1 chromatin-remodelling enzyme contains SANT and SLIDE domains [PDF]

, 2011
The ATP-dependent chromatin-remodelling enzyme Chd1 is a 168-kDa protein consisting of a double chromodomain, Snf2-related ATPase domain, and a C-terminal DNA-binding domain.
Aasland, Adams, Alen, Awad, Bailey, Baker, Baudin, Bird, Biswas, Biswas, Blank, Blosser, Boyer, Cairns, Chen, Cheng, Clapier, Clapier, Corona, Dang, Daniel P Ryan, Daubresse, David Martin, de Vries, Delmas, Eberharter, Eddy, Emsley, Fazzio, Ferreira, Flanagan, Flaus, Gangaraju, Gaspar-Maia, Grune, Hamiche, Hauk, Holm, Konev, Kouzarides, Lin, Lusser, McDaniel, Morettini, Okuda, Painter, Park, Pinskaya, Racki, Ramasubramanian Sundaramoorthy, Robinson, Sikorski, Simic, Sims, Stockdale, Stokes, Thastrom, Thompson, Tom Owen-Hughes, Tran, Tsukiyama, Vijender Singh, Walfridsson, Waterhouse, Yang, Zentner   +65 more
core   +4 more sources

Comprehensive nucleosome interactome screen establishes fundamental principles of nucleosome binding

Nucleic Acids Research, 2020
Nuclear proteins bind chromatin to execute and regulate genome-templated processes. While studies of individual nucleosome interactions have suggested that an acidic patch on the nucleosome disk may be a common site for recruitment to chromatin, the ...
Aleksandra Skrajna, D. Goldfarb, K. Kedziora, E. Cousins, Gavin D. Grant, C. Spangler, Emily H. Barbour, Xiaokang Yan, Nathaniel A. Hathaway, N. Brown, J. Cook, Michael B. Major, R. McGinty   +12 more
semanticscholar   +1 more source

Thermodynamic modeling of genome-wide nucleosome depleted regions in yeast.

PLoS Computational Biology, 2021
Nucleosome positioning in the genome is essential for the regulation of many nuclear processes. We currently have limited capability to predict nucleosome positioning in vivo, especially the locations and sizes of nucleosome depleted regions (NDRs). Here,
Hungyo Kharerin, Lu Bai
doaj   +1 more source

Crystal Structure of the LSD1/CoREST Histone Demethylase Bound to Its Nucleosome Substrate.

Molecules and Cells, 2020
LSD1 (lysine specific demethylase; also known as KDM1A), the first histone demethylase discovered, regulates cell-fate determination and is overexpressed in multiple cancers.
Sang-Ah Kim, Jiang Zhu, N. Yennawar, Priit Eek, Song Tan   +4 more
semanticscholar   +1 more source

Chromatin—a global buffer for eukaryotic gene control

AIMS Biophysics, 2015
Most of eukaryotic DNA is embedded into nucleosome arrays formed by DNA wrapped around a core histone octamer. Nucleosome is a fundamental repeating unit of chromatin guarding access to the genetic information.
Yuri M. Moshkin
doaj   +1 more source

The Snf2 Homolog Fun30 acts as a homodimeric ATP-dependent chromatin-remodeling enzyme [PDF]

, 2010
The Saccharomyces cerevisiae Fun30 (Function unknown now 30) protein shares homology with an extended family of Snf2-related ATPases. Here we report the purification of Fun30 principally as a homodimer with a molecular mass of about 250 kDa.
Adra, Ahmed H. Hassan, Barton, Becker, Bruno, Cairns, Clark, Collins, Daniel Ryan, Dillingham, Ferreira, Ferreira, Flaus, Flaus, Gavin, Hartley, Hassan, Hassan, Kouzarides, Krogan, Lowary, Luger, Mizuguchi, Neves-Costa, Okazaki, Ouspenski, Papamichos-Chronakis, Philippe Prochasson, Puig, Racki, Salma Awad, Schoor, Schoor, Shih, Smith, Soininen, Stockdale, Strohner, Suter, Thåström, Tom Owen-Hughes, Ubersax, Whitehouse, Zofall   +43 more
core   +4 more sources