Results 41 to 50 of about 141,257 (371)
Conservation of Nucleosome Positions in Duplicated and Orthologous Gene Pairs
The Scientific World Journal, 2012 Although nucleosome positions tend to be conserved in gene promoters, whether they are conserved in duplicated and orthologous genes is unknown. In order to elucidate how nucleosome positions are conserved between duplicated and orthologous gene pairs, I
Hiromi Nishida
doaj +1 more source
BMC Evolutionary Biology, 2011 Background Divergence of transcription factor binding sites is considered to be an important source of regulatory evolution. The associations between transcription factor binding sites and phenotypic diversity have been investigated in many model ...
Chu Wen-Yi +4 more
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Ion counting demonstrates a high electrostatic field generated by the nucleosome
eLife, 2019 In eukaryotes, a first step towards the nuclear DNA compaction process is the formation of a nucleosome, which is comprised of negatively charged DNA wrapped around a positively charged histone protein octamer.
Magdalena Gebala +3 more
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Dynamic nucleosome landscape elicits a noncanonical GATA2 pioneer model
Nature Communications, 2022 Here the authors provide a multi-omic study of the nucleosome landscape in LNCaP cells and observe nine functional nucleosome states each with characteristic nucleosome footprints.
Tianbao Li +7 more
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Nucleosomes affect local transformation efficiency [PDF]
, 2012 Genetic transformation is a natural process during which foreign DNA enters a cell and integrates into the genome. Apart from its relevance for horizontal gene transfer in nature, transformation is also the cornerstone of today's recombinant gene ...
Aslankoohi, Elham +6 more
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Genomic sequence is highly predictive of local nucleosome depletion. [PDF]
PLoS Computational Biology, 2008 The regulation of DNA accessibility through nucleosome positioning is important for transcription control. Computational models have been developed to predict genome-wide nucleosome positions from DNA sequences, but these models consider only nucleosome ...
Guo-Cheng Yuan, Jun S Liu
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Thermodynamic modeling of genome-wide nucleosome depleted regions in yeast.
PLoS Computational Biology, 2021 Nucleosome positioning in the genome is essential for the regulation of many nuclear processes. We currently have limited capability to predict nucleosome positioning in vivo, especially the locations and sizes of nucleosome depleted regions (NDRs). Here,
Hungyo Kharerin, Lu Bai
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Crystal Structure of the LSD1/CoREST Histone Demethylase Bound to Its Nucleosome Substrate.
Molecules and Cells, 2020 LSD1 (lysine specific demethylase; also known as KDM1A), the first histone demethylase discovered, regulates cell-fate determination and is overexpressed in multiple cancers.
Sang-Ah Kim +4 more
semanticscholar +1 more source
Nucleosome footprinting in plasma cell-free DNA for the pre-surgical diagnosis of ovarian cancer
npj Genomic Medicine, 2022 Fragmentation patterns of plasma cell-free DNA (cfDNA) are known to reflect nucleosome positions of cell types contributing to cfDNA. Based on cfDNA fragmentation patterns, the deviation in nucleosome footprints was quantified between diagnosed ovarian ...
Adriaan Vanderstichele +20 more
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The histone chaperones Nap1 and Vps75 bind histones H3 and H4 in a tetrameric conformation [PDF]
, 2011 Histone chaperones physically interact with histones to direct proper assembly and disassembly of nucleosomes regulating diverse nuclear processes such as DNA replication, promoter remodeling, transcription elongation, DNA damage, and histone variant ...
Bowman, A. +6 more
core +4 more sources