Results 61 to 70 of about 141,257 (371)

Evaluation of nucleosome forming potentials (NFPs) of forensically important STRs [PDF]

, 2011
Degraded forensic samples have proved difficult to analyze and interpret. New analysis techniques are constantly being discovered and improved but researchers have overlooked the structural properties that could prevent or slow the process of degradation.
Thanakiatkrai, Phuvadol, Welch, Lindsey
core   +1 more source

Nucleosome free regions in yeast promoters result from competitive binding of transcription factors that interact with chromatin modifiers. [PDF]

PLoS Computational Biology, 2013
Because DNA packaging in nucleosomes modulates its accessibility to transcription factors (TFs), unraveling the causal determinants of nucleosome positioning is of great importance to understanding gene regulation.
Evgeniy A Ozonov, Erik van Nimwegen
doaj   +1 more source

FACT caught in the act of manipulating the nucleosome

Nature, 2019
The organization of genomic DNA into nucleosomes profoundly affects all DNA-related processes in eukaryotes. The histone chaperone known as ‘facilitates chromatin transcription’ (FACT 1 ) (consisting of subunits SPT16 and SSRP1) promotes both disassembly
Yang Liu, Keda Zhou, Naifu Zhang, Hui Wei, Yong Zi Tan, Zhening Zhang, B. Carragher, C. Potter, Sheena D'arcy, K. Luger   +9 more
semanticscholar   +1 more source

Nucleosomes and Cisplatin

Chemistry & Biology, 2010
In order to form a covalent complex with DNA inside human cells, cisplatin has to overcome the protective environment of a nucleosome, where DNA is complexed with histone proteins. Todd and Lippard (2010) expand our understanding of this process by describing the structure of a nucleosome containing a Pt-DNA adduct, which has important implications for
openaire   +3 more sources

Theory of Nucleosome Corkscrew Sliding in the Presence of Synthetic DNA Ligands

, 2004
Histone octamers show a heat-induced mobility along DNA. Recent theoretical studies have established two mechanisms that are qualitatively and quantitatively compatible with in vitro experiments on nucleosome sliding: Octamer repositiong through one ...
Kulic, Igor M., Mohammad-Rafiee, Farshid, Schiessel, H.   +2 more
core   +2 more sources

The dynamics of individual nucleosomes controls the chromatin condensation pathway: direct AFM visualization of variant chromatin [PDF]

, 2009
Chromatin organization and dynamics is studied in this work at scales ranging from single nucleosome to nucleosomal array by using a unique combination of biochemical assays, single molecule imaging technique and numerical modeling. We demonstrate that a
Akiyama, Angelov, Bao, Boulard, Cendrine Faivre-Moskalenko, Chadwick, Claudet, Dalal, Dimitar Angelov, Doyen, Fabien Montel, Gautier, Gonzales, Gonzalez-Romero, Hervé Menoni, Huynh, Jan Bednar, Kepert, Koch, Lebedev, Lowary, Luger, Luger, Lyubchenko, Martin Castelnovo, Menoni, Montel, Mutskov, Poirier, Robinson, Robinson, Routh, Schalch, Schiessel, Shogren-Knaak, Sims, Stefan Dimitrov, Valle, van Holde, Wu, Yodh, Zhou, Zlatanova   +42 more
core   +4 more sources

Exploring the Link between Nucleosome Occupancy and DNA Methylation

Frontiers in Genetics, 2018
Near promoters, both nucleosomes and CpG sites form characteristic spatial patterns. Previously, nucleosome depleted regions were observed upstream of transcription start sites and nucleosome occupancy was reported to correlate both with CpG density and ...
Cecilia Lövkvist, Kim Sneppen, Jan O. Haerter   +2 more
doaj   +1 more source

Architecture of the chromatin remodeler RSC and insights into its nucleosome engagement. [PDF]

, 2019
Eukaryotic DNA is packaged into nucleosome arrays, which are repositioned by chromatin remodeling complexes to control DNA accessibility. The Saccharomyces cerevisiae RSC (Remodeling the Structure of Chromatin) complex, a member of the SWI/SNF chromatin ...
Afonine, Afonine, Allen, Angus-Hill, Ashkenazy, Ashkenazy, Asturias, Badis, Buchan, Buchan, Cairns, Cairns, Campsteijn, Chaban, Chambers, Chatterjee, Clapier, Clapier, Côté, Da, Dechassa, Duan, Dutta, Dürr, El-Gebali, Emsley, Erkina, Filippakopoulos, Goddard, Han, Jones, Jones, Kadoch, Kasten, Klein-Brill, Krietenstein, Kuryan, Leschziner, Leschziner, Li, Liu, Lopéz-Blanco, Mashtalir, Morin, Nagai, Nakane, Ng, Patel, Pettersen, Puig, Saha, Sammak, Schorb, Schubert, Sen, Shim, Sievers, Skiniotis, Smith, Suloway, Söding, Tan, Tsunaka, Ungar, Valencia, Wagner, Wang, Wilson, Xia, Yan, Yang, Ye, Yen, Zhang, Zhang, Zhang, Zheng, Zivanov, Zivanov, Zukin   +79 more
core   +3 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Structural characterization of H3K56Q nucleosomes and nucleosomal arrays [PDF]

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2010
The post-translational modification of histones is a key mechanism for the modulation of DNA accessibility. Acetylated lysine 56 in histone H3 is associated with nucleosome assembly during replication and DNA repair, and is thus likely to predominate in regions of chromatin containing nucleosome-free regions.
Karolin Luger, Karolin Luger, Michael G. Resch, Nicholas J. Clark, Shinya Watanabe, Wayne Lilyestrom, Jeffrey C. Hansen, Craig L. Peterson   +7 more
openaire   +3 more sources